Sökresultat

Background In several countries, whole-body imaging has been introduced in the routine follow-up of individuals with high-risk cutaneous malignant melanoma after surgery. However, there is scarce evidence that earlier detection of recurrent disease by regular scanning improves survival. In this interim analysis, we investigated whether imaging in the follow-up programme for high-risk cutaneous mal

Introduction: A grey-white matter ratio (GWR) < 1.10 at the basal ganglia level on head computed tomography (CT) previously predicted poor outcome with high specificity and moderate sensitivity in cardiac arrest patients. Data on GWR in reference populations are lacking. We explored GWR in a reference group to a cardiac arrest population and hypothesised that none would have GWR < 1.10. Methods: A

S100A8 plays a critical role in the pathogenesis of several inflammatory diseases and multiple types of cancer. Therefore, targeting the S100A8 function may alleviate the pathogenic process in various diseases. Here, specific single-chain variable fragment (scFv) antibodies targeting recombinant S100A8 (rS100A8) were selected by phage display technique and characterized using cDNA sequencing, immu

Radiotherapy (RT) with concurrent chemotherapy is the standard of care for squamous-cell carcinoma of the anal canal (SCCAC), achieving favorable results in terms of local control and overall survival. However, locoregional failure remains common despite advances such as intensity-modulated radiotherapy (IMRT), which reduces toxicity but has limitations. Despite the benefits of IMRT, frequent and

Water scarcity is a global problem and refers to a situation where the demand for water exceeds the available quantity over a given period or if sufficient water is available, the quality of the water is poor and its use is limited. The issue of water scarcity is very complex and is affected by a wide range of natural and anthropogenic factors. Water scarcity can arise from different aspects: (i)

Case volume per 100 000 population and perioperative mortality rate (POMR) are key indicators to monitor and strengthen surgical services. However, comparisons of POMR have been restricted by absence of standardised approaches to when it is measured, the ideal denominator, need for risk adjustment, and whether data are available. We aimed to address these issues and recommend a minimum dataset by

Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1) adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of basal Jak activity, but the mechanism of this regulation has remained elusive. We show that JH2 negatively regulated Jak2 in bacterial cells, indicating that regulation is an intrinsic property of Jak2. JH2 suppressed

Numerical analysis, such as the finite element method is the most used computational procedure for nonlinear deformation and strength analysis of structures. In order to obtain meaningful results the material behaviour must be described and simulated accurately. Another important element in order to perform the simulation is a robust and accurate numerical integration algorithm. The present paper

We investigating the role of anticipation and attention in a dynamic environment in a number of large scale simulations of an agent that tries to negotiate a number of gates that continuously open and close. In particular we have looked at learning mechanisms that can predict the future positions of the gates and control strategies that will allow the agent to pass through the gates unharmed. The

The present dissertation delineates how the fairy tale character, Little Red Riding Hood, has appeared in different screen versions. It is a thematic and historical analysis of the development of film versions and other traces of the story 1901 to 2001, focussing particulary on the representation of Red Riding Hood herself. The story of this little girl, mostly dressed in different red garments, i

This article deals with the early development of the Jesus prayer in Early Christian monasticism of the 4th to the 7th century. It proceeds in two steps. First, a quite uniform matrix of practices and aims related to three early monastic authors (John Cassian, Diadochus of Photike, and John Climacus) is discerned. It is evident that the practice is not clearly defined in this period. It is also ap

The Sound Area, located between Sweden and Denmark, is one of the most intensely trafficked waters in the world with complex traffic patterns and a bridge/tunnel under construction, which will link the two countries. This high level of complexity increases the probability of both maritime accidents and very negative consequences of them. This paper presents the ergonomic part of an ongoing multidi

This chapter provides a physical background to the following ones. It describes the particle and wave properties of light and the diffraction, polarization, refraction, reflection, and absorption of light and statistics of photon emission and absorption. Planck’s law of heat radiation is described in various mathematical and graphical ways. One section is devoted to a simplified description of the

In many reports the improvements of the actors in the construction sector have been requested. One explicit factor that has been called for is an increase in cooperation and communication between the different actors. The Swedish construction sector in general has not been swift in accepting new process improvements as they have been put forward by academics or government. There are many possible