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BACKGROUND: No studies have examined long-term risks for aortic aneurysm (AA) and aortic dissection (AD) or mortality after AA or AD hospitalization among patients with type 2 diabetes mellitus (T2DM).METHODS AND RESULTS: In this observational cohort study, we linked data for patients with T2DM in the Swedish National Diabetes Register, and 5 individually matched population-based control subjects

The ISO22400 standard defines key performance indicators for manufacturing operation management. Its visionary goal is to be applicable to all industry types, regardless the production methodology and the process configuration. Pursuing this objective, a challenging trade-off between generality and specificity in the definitions must be found. In the cited standard, the former approach has been pr

During a metal cutting process, chemical wear can become the dominant mechanism of tool degradation under the high temperatures and contact pressures that arise between the tool and the metal workpiece. This study focuses on the chemical and diffusional interactions between superalloy Inconel 718 and cubic boron nitride (cBN) tool material with and without TiC binder. It covers thermodynamic model

In this study, vegetation optical depth from ESA's Soil Moisture and Ocean Salinity (SMOS) satellite mission is combined with other existing remote sensing, meteorological and literature data in order to obtain values of gravimetric vegetation water content (Mg). The methodology combines an effective medium model valid at passive microwave frequencies with a vegetation dielectric constant model. T

Aim: To assess Ig20Gly tolerability in pediatric patients with primary immunodeficiencies. Patients & methods: Infusion parameters and tolerability were analyzed in pediatric patients (aged 2-5 years [n = 6], 6-11 years [n = 22] and 12-17 years [n = 22]) receiving Ig20Gly in two Phase II/III trials. Results: Of 2624 Ig20Gly infusions, >99% did not require any rate reduction, interruption or di

In vitro generation of antibodies often requires variable domain sequence evolution to adapt the protein in terms of affinity, specificity, or developability. Such antibodies, including those that are of interest for clinical development, may have their origins in a diversity of immunoglobulin germline genes. Others and we have previously shown that antibodies of different origins tend to evolve a

This study offers a method for empirically testing theories operationalized in the form of multivariate statistical models. An innovation of the method is that it distinguishes testing into three separate forms, “effect testing,” “prediction testing,” and “theory testing,”where statistical significance plays a separate role in each one. In another innovation, the researcher specifies not only his

We report a new study of the V i atom using a combination of time-resolved laser-induced fluorescence and Fourier transform spectroscopy that contains newly measured radiative lifetimes for 25 levels between 24,648 cm-1 and 37,518 cm-1 and oscillator strengths for 208 lines between 3040 and 20000 from 39 upper energy levels. Thirteen of these oscillator strengths have not been reported previously.

IL-18 has been implicated in inflammatory bowel disease (IBD), however its role in the regulation of intestinal CD4+ T-cell function remains unclear. Here we show that murine intestinal CD4+ T cells express high levels of IL-18Rα and provide evidence that IL-18Rα expression is induced on these cells subsequent to their entry into the intestinal mucosa. Using the CD45RBhi T-cell transfer colitis mo

Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to distinguish protective from destructive effects of innate immune activation and selectively attenuate molecular nodes that create pathology. Here, we identify acute cystitis as an Interleukin-1 beta (IL-1β)-driven, hyper-inflammatory condition o

The expansion of pollinator-dependent crops, especially in the developing world, together with reports of worldwide pollinator declines, raises concern of possible yield gaps. Farmers directly reliant on pollination services for food supply often live in regions where our knowledge of pollination services is poor. In a manipulative experiment replicated at 23 sites across an Ethiopian agricultural

The overall kinetics for manganese(II/III) catalyzed autoxidation of dissolved sulfur dioxide has been studied by UV-vis spectrophotometry. A free-radical mechanism has been proposed, and the rate constant for one of the key reactions between manganese(II) and peroxomonosulfate has been determined by pulse radiolysis. Previous literature on manganese catalyzed autoxidation of SO2(aq) has been thor

CD103+CD11b+ dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103+CD11b+ DC and altered T cell differentiation to protein antigen. The influence of CD103+CD11b+ DC

Den här avhandlingen undersöker Stockholms boulevardpress under det sena 1800-talet. Studiens huvudsakliga empiriska material utgörs av de fyra boulevardveckotidningarna Figaro, Vikingen, Budkaflen och Hvad Nytt. Boulevardpressens största intresse var den lokala societeten och de teatrar och restauranger den frekventerade. Syftet med avhandlingen är att undersöka tidningstypen med särskild hänsyn

Remains of a basilican round church were discovered in 1877–78 in Tønsberg, Norway, and identified as the Premonstratensian monastery church of Saint Olav. The round church has been interpreted as fortified with several floors using Nylars on Bornholm in Denmark as a model – or as symbolic copy of Holy Sepulchre in Jerusalem, although Templar churches have also been mentioned as models. The church

The activation of the complement system is a key initiating step in the protective innate immune-inflammatory response against injury, although it may also cause harm if left unchecked. The structurally related soluble complement inhibitors C4b-binding protein (C4BP) and factor H (FH) exert a tight regulation of the classical/lectin and alternative pathways of complement activation, respectively,

Surface display couples genotype with a surface exposed phenotype and thereby allows screening of gene-encoded protein libraries for desired characteristics. Of the various display systems available, phage display is by far the most popular, mainly thanks to its ability to harbour large size libraries. Here, we describe the first use of a Gram-positive bacterial host for display of a library of hu