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Background: The clinical importance of immediate coronary angiography, with potentially subsequent percutaneous coronary intervention (PCI), in out-of-hospital cardiac arrest (OHCA) patients without ST-elevation on the ECG is unclear. In this study, we assessed feasibility and safety aspects of performing immediate coronary angiography in a pre-specified pilot phase of the ‘DIrect or Subacute Coro

Radiological evaluation of incidentally detected lung nodules on computed tomography (CT) influences management. We assessed international radiological variation in 1) pulmonary nodule characterisation; 2) hypothetical guideline-derived management; and 3) radiologists' management recommendations.107 radiologists from 25 countries evaluated 69 CT-detected nodules, recording: 1) first-choice composi

The particle longitudinal dynamics is affected by errors on the phase and amplitude of the electro-magnetic field in each cavity that cause emittance growth, beam degradation and losses. One of the causes of the phase error is the change of the ambience temperature in the LINAC tunnel, in the stub and in the klystron gallery that induces a phase drift of the signal travelling through the cables an

The acceleration of developing magnesium alloys for biomedicine requires the advancement of experimental methods evaluating their performance. We have been developing an advanced immersion testing method for the assessment of biomedical Mg alloy degradation in aqueous environments. It is based on the combination of isothermal calorimetry with pressure measurement in the reaction cell. Such a combi

Using the newly described streptococcal surface protein, protein G, which has powerful immunoglobulin G binding properties, solid-phase radioimmunoassays were developed for the quantitation of goat and rat immunoglobulin G bound to the plastic surface of microtiter plates. The binding of goat immunoglobulin G to the surface via a specific antigen (guinea pig alpha 1-microglobulin) permitted the de

Buildings are getting taller due to increased urbanisation and densification of cities. More advanced construction methods and the desire to construct impressive buildings is also supporting the trend. Due to their inherent slenderness resulting in low eigenfrequencies, these buildings are susceptible to wind-induced vibrations which can be highly disturbing for occupants. Already barely perceivab

We analyze the convergence rate of the Dirichlet-Neumann iteration for the fully discretized one dimensional unsteady transmission problem. Specifically, we consider the coupling of two linear heat equations on two identical non overlapping intervals. The Laplacian is discretized using finite differences on one interval and finite elements on the other and the implicit Euler method is used for the

CONTEXT: Turner syndrome (TS) is the most common chromosomal aberration in women; it is the result of structural or numeric abnormalities in the X chromosome. Autoimmune hypothyroidism has been recognized as one of the more prominent disorders associated with TS. OBJECTIVE: This work aimed to study the prevalence of autoimmune diseases in TS. METHODS: A cross-sectional, longitudinal, 25-year follo

Background: The aim of this study was to investigate the development of fatigue and mental illness between 3 and 12 months after critical COVID-19 and explore risk factors for long-lasting symptoms. Study Design and Methods: A prospective, multicenter COVID-19 study in southern Sweden, including adult patients (≥18 years) with rtPCR-confirmed COVID-19 requiring intensive care. Survivors were invi

BACKGROUND: By causing inflammation and tissue damage, neutrophil extracellular traps (NETs) constitute an underlying mechanism of aspiration-induced lung injury, a major factor of the low utilization of donor lungs in lung transplantation (LTx).METHOD: To determine whether NET removal during ex vivo lung perfusion (EVLP) can restore lung function and morphology in aspiration-damaged lungs, gastri

This paper presents initial research within a broader discourse about smart cities. Despite the existence of various discussions about the concept many questions are still opened. We bridge the gap by investigating the role of local governments and their initiatives to integrate new technologies in a city context. The study aims to investigate the adoption of technological innovation in smart citi

PURPOSE: Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden the applicability of this treatment. We evaluated the use of vemurafenib, a small-molecule BRAF inhibitor with immunomodulatory properties, as priming before TIL harvest and adopti

Periodic structures are known to produce passbands and stopbands for propagation of vibration energy within the frequency domain. Sources vibrating harmonically at a frequency within a passband can lead to propagation of energy through propagating modes over long distances. However, sources vibrating at a frequency within a stopband excite only nearfields in the form of attenuating and evanescent

Purpose: PFAPA syndrome is a benign, recurrent inflammatory disease of childhood. Tonsillectomy is one of the therapeutic options with a yet unexplained biological mechanism. We tested whether specific lymphocyte subsets recruited from blood to human tonsils participate in PFAPA pathogenesis. Methods: Paired tonsils/peripheral blood (PB) samples were investigated (a) from children with PFAPA that

Background: The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranul

Objective: To explore associations between four methods assessing long-term neurocognitive outcome after out-of-hospital cardiac arrest and early hypoxic-ischemic neuronal brain injury assessed by the biomarker serum neurofilament light (NFL), and to compare the agreement for the outcome methods. Methods: An explorative post-hoc study was conducted on survivor data from the international Target Te

When conducting randomised clinical trials, the choice of methodology and statistical analyses will influence the results. If the planned methodology is not of optimal quality and predefined in detail, there is a risk of biased trial results and interpretation. Even though clinical trial methodology is already at a very high standard, there are many trials that deliver biased results due to the im

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un

Objective: The association between mammographic density (MD) and breast cancer (BC) recurrence and survival remains unclear. Patients receiving neoadjuvant chemotherapy (NACT) are in a vulnerable situation with the tumor within the breast during treatment. This study evaluated the association between MD and recurrence/survival in BC patients treated with NACT. Methods: Patients with BC treated wit