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Implant migration and functional outcome of Reverse Shoulder Lateralized Glenosphere Line Extension System : a study protocol for a randomized controlled trial

Background: Inferior scapular notching is a complication unique to reverse shoulder arthroplasty. The most efficient technique to avoid inferior scapular notching has been reported to be lateralization of the glenoid offset. This study aims to compare radiological and functional outcomes of the DELTA Xtend® Reverse Shoulder System Lateralized Glenosphere Line Extension (intervention group) with th

Multi-actor business models in the manufacturing industry. Exploring how first-tier suppliers transition towards circularity.

Adopting circular business models (CBM) represents a key lever for industry to address urgent global challenges. Prior research recognizes the need for systems thinking and collaboration, but existing CBM tools and methods often implicitly assume that the focal firm has direct access to end customers, usage data and end-of-life phases. However, upstream suppliers who lack this access often produce

Adopting business models for sustainability and digitalization. A process study of microlevel dynamics in an incumbent firm.

Incumbent firms face growing pressure to transform their business towards sustainability. However, business models for sustainability (BMfS) and circularity are grounded in fundamentally different institutional logic which, for incumbents, creates tensions with existing business models, structures and routines. How organizations manage tensions from conflicting logics is explored comprehensively i

The prognostic value of programmed death-ligand 1 (PD-L1) expression in resected colorectal cancer without neoadjuvant therapy - differences between antibody clones and cell types

BACKGROUND: Programmed death-ligand 1 (PD-L1) expression on tumor cells is associated with poor prognosis in several malignancies, while partly contradictory and inconclusive results have been presented for colorectal cancer (CRC). This study aimed to evaluate PD-L1 as a prognostic biomarker in CRC by comparing three different antibody clones.METHODS: Patients surgically treated for CRC between Ja

STUDY OF THE VARIATION IN COMPONENT LEVEL CHARACTERISTICS OF A CENTRIFUGAL COMPRESSOR ACROSS THE COMPRESSOR MAP USING CFD AND EXPERIMENTS WITH DETAILED INSTRUMENTATION ON A GAS STAND

A compressor map with variations in component level characteristics is introduced. This novel approach to plot component level characteristics identify and give context to the critical design parameters such as flow angles, pressure coefficients, and loss coefficients across the entire compressor map along with the conventional performance parameters. Compressor design involves a significant amoun

Climate change and the energy transition: what role for Article 101 (3) TFEU?

This chapter explores the interaction between competition law and especially Article 101(3) TFEU and environmental and climate change goals in the context of the EU’s Green Deal and the aim of energy transition. First, it reviews the evolution of the Commission’s and national authorities’ approaches to environmental and climate benefits in their general assessment of horizontal and vertical agreem

Higher target attainment for B-lactam antibiotics in patients with Gram-negative bloodstream infections when four times actual minimum inhibitory concentrations and epidemiological cutoff values are applied compared to clinical breakpoints

IntroductionBeta-lactam antibiotics are essential in the treatment of Gram-negative bloodstream infections. The effect of beta-lactam antibiotics depends on the time of unbound antibiotic concentration above the minimal inhibitory concentration (MIC). An antibiotic concentration above MIC during the whole dosing interval (100% ƒT > MIC) has been suggested as a target for severe infections. The aim

An Exploratory Study of an Enterprise Systems Implementation Methodology in Action

In this paper we develop an Enterprise Systems Implementation Methodology in Action framework. The framework is grounded in contemporary views on methodology in action (theoretical grounding) and enhanced by an empirical study (empirical grounding). The notion of Implementation Methodology in Action, as articulated in this paper, integrates two complementary views that conceptualise a methodology

The mobile Oracle: a tool for early user involvement

This paper describes a novel tool for eliciting user requirements early in the design process of mobile applications. The "Mobile Oracle", as we have called it, is intended to help developers and designers obtain a better understanding of what the user wants at different points in space and time. It is an extension of a lo-fi version of the well-established Wizard of Oz technique, but it adds an "

Sinuosity effects on Longitudinal Dispersion Coefficient

A method for reaching longitudinal dispersion coefficient accounting sinuosity effects is suggested. The proposed method was verified using 43 sets of measured field data from previous study were collected from 30 streams and these data were chosen depends on characteristics availability (flow parameters, fluid properties and Sinuosity). Statistical programs namely MINITAB and SPSS were used to de

Three applications of virtual reality for brain injury rehabilitation of daily tasks

Part of the process of rehabilitation after a brain injury is the relearning of various daily tasks such as preparing food, managing finances, getting from one place to another and so forth. These tasks require learning on all levels from physical to cognitive. Remembering a PIN code for a bank card, for example, can become automatic and ‘in the fingers’ after much repetition. However, other tasks

Temperature-dependent electronic and vibrational structure of the 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide room-temperature ionic liquid surface: a study with XPS, UPS, MIES, and HREELS.

The near-surface structure of the room-temperature ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide has been investigated as a function of temperature between 100 and 620 K. We used a combination of photoelectron spectroscopies (XPS and UPS), metastable induced electron spectroscopy (MIES), and high-resolution electron energy loss spectroscopy (HREELS). The valence band a

N-methyl-d-aspartate receptor autoimmunity affects cognitive performance in herpes simplex encephalitis

Objectives: To investigate the prevalence and temporal development of . N-methyl-d-aspartate receptor (NMDAR) autoantibodies in relation to neurocognitive performance in patients with herpes simplex encephalitis (HSE). Methods: This prospective observational study enrolled a total of 49 HSE patients within a randomized controlled trial of valacyclovir. Cerebrospinal fluid and serum samples were dr

Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection

Helicobacter pylori is the most important cause of gastritis, peptic ulcers and the development of gastric cancer. The chronic active inflammation is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins (IL-8, IL-10 and IFN-gamma) are involved in the inflammatory process in the gastric mucosa. The aim of this study was to investigate the gastric inflammation in

Triage of women with equivocal or low-grade cervical cytology results: a meta-analysis of the HPV test positivity rate

Introduction Methods Results Discussion Conclusion Consistent evidence underlines the utility of human papillomavirus (HPV) DNA testing in the management of women with equivocal cervical cytological abnormalities, but not in case of low-grade lesions. We performed a meta-analysis including studies where the high-risk probe of the Hybrid Capture-II is used to triage these two cytological categories

Association of free-prostate specific antigen subfractions and human glandular kallikrein 2 with volume of benign and malignant prostatic tissue

BACKGROUND. We investigated the association of different subfractions of prostate specific antigen (PSA) and human glandular kallikrein 2 (hK2), such as total PSA (tPSA), complexed PSA (cPSA), free PSA (fPSA), "single-chain Intact fPSA" (fPSA-I), "multi-chain nicked fPSA" (fPSA-N), and total hK2 with volumes of total prostate gland, transition zone (tz), and prostate cancer (PCa) tissue in patient