Filtyp
ABSTRACT Optimal breeding of mice is very important in biomedical science today. The understanding why some strains breed better and some worse enable scientists to create better in vivo models for human diseases. The aim of this thesis was to identify and characterize new genetic regions linked to reproductive performance and autoimmune inflammation in female mice. Collagen-induced arthritis (CIA
When developing products, engineering designers often face the problem that their candidate for a technical solution, ranging from a concept to a detailed design, needs to be analyzed by a design analyst before it is approved or rejected and the engineering designer can continue his/her activities within the product development process. If engineering designers have to send every solution candidat
People who have visual impairments may have difficulties navigating freely and without personal assistance, and some are even afraid to go out alone. Current navigation devices with non-visual feedback are quite expensive, few, and are in general focused on routing and target finding. We have developed a test prototype application running on the Android platform in which a user may scan for map in
Gene amplification is a common phenomenon in malignant neoplasms of all types. One mechanism behind increased gene copy number is the formation of ring chromosomes. Such structures are mitotically unstable and during tumor progression they accumulate material from many different parts of the genome. Hence, their content varies considerably between and within tumors. Partly due to this extensive va
Many men with elevated prostate-specific antigen (PSA) levels in serum do not have aggressive prostate cancer and undergo unnecessary biopsy. Retrospective studies using cryopreserved serum suggest that four kallikrein markers can predict biopsy outcome.
Objectives The aim of the study was to examine the predictive value of QRS duration and morphology during watchful waiting in asymptomatic patients with aortic stenosis (AS). Background QRS duration and morphology are associated with poor prognosis in many different populations, but the predictive value, particularly of the risk of sudden cardiac death (SCD), in asymptomatic patients with AS has n
In recent years, extreme flow events in rivers have become more frequent and caused numerous bridge failures worldwide. Such events increase headwater levels in the rivers that may cause water to flow over the bridge deck, referred to as bridge overtopping. This is one of the primary factors affecting bridge functionality, possibly leading to failure. In general, bridges are designed and construct
The purpose of this essay is to present the conclusions and recommendations in the Goldstone report that were given to the state of Israel, as well as presenting the state of Israel’s response and presented investigations against the allegations. Along with that, a presentation of Amnesty International’s updated assessment will be given along with its criticism towards the state of Israel due to t
Purpose: The small molecule inhibitors larotrectinib and entrectinib have recently been approved as cancer agnostic drugs in patients with tumours harbouring a rearrangement of the neurotrophic tropomyosin receptor kinase (NTRK). These oncogenic fusions are estimated to occur in 0.1–3 % of non-small cell lung cancers (NSCLC). Although molecular techniques are most reliable for fusion detection, im
Studies of fusion genes have mainly focused on the formation of fusions that result in the production of hybrid proteins or, alternatively, on promoter-switching events that put a gene under the control of aberrant signals. However, gene fusions may also disrupt the transcriptional control of genes that are encoded in introns downstream of the breakpoint. By ignoring structural constraints of the
Increasing use of antibiotics and rising levels of bacterial resistance to antibiotics are a challenge to global health and development. Successful initiatives for containing the problem need to be communicated and disseminated. In Sweden, a rapid spread of resistant pneumococci in the southern part of the country triggered the formation of the Swedish strategic programme against antibiotic resist
PurposeThere is a growing demand for a concurrent development of product and packaging in order to better take into account the supply chain needs. Different tasks are required to integrate packaging and product development: 1) At the strategic level, it is necessary to define or refine an integrated development policy; 2) For each new development project, an adaptation of this policy must be unde
Popular Abstract in Swedish Sammanfattning Bengt Lidforss (1868–1913) växte upp i ett konservativt professorshem i Lund. Han var mycket intelligent, och till att börja med var han också en lika skötsam som framgångsrik student. Han tog en omfattande och mycket uppmärksammad filosofie kandidatexamen redan vid 19 års ålder. Karriären borde alltså ha gått spikrakt fram till professuren i botanik, meBengt Lidforss (1868-1913) was professor of botany between 1910 and 1913. But after the turn of the century he also emerged as a charismatic leader within the Swedish working-class movement. He became one of its foremost publicists. In the social democratic newspaper Arbetet in Malmö he wrote about natural sciences but also about political, philosophical and literary issues. As a literary critic
The dissertation explores the relationship between Aby Warburg’s unfinished picture atlas Mnemosyne and the visualization of Art History around 1800/1900 in an attempt to understand the historical conditions regarding the picture atlas and other visual devices constructed by Warburg and his staff at the Kulturwissenschaftlichen Bibliothek Warburg (K.B.W.) in Hamburg during the 1920s. The dissertat
The main objective was to compare short wave radiation from Thorn lamp to solar radiation. In sun all manikin front zones get more or less evenly radiated but in the lab the radiated power reaches some zones more than others. Tests were carried out on the thermal manikin Tore under clear sky in a building corner facing the sun. The manikin was turned so that in the end of each trial the sun faced
Computer-based design analysis is nowadays a common activity in most development projects. Used for design evaluation, verification, validation, or as a support for design exploration, it fulfils an important support function for the engineering designer, thus making it essential to have an operationally efficient and effective integration between both the engineering design and design analysis ac
In this paper we develop an Enterprise Systems Implementation Methodology in Action framework. The framework is grounded in contemporary views on methodology in action (theoretical grounding) and enhanced by an empirical study (empirical grounding). The notion of Implementation Methodology in Action, as articulated in this paper, integrates two complementary views that conceptualise a methodology
