Sökresultat

The paper presents the major findings from the three evacuation experiments being part of the Swedish METRO research project. In the evacuation experiments; the small, medium and full-scale experiments, investigations were carried out with the purpose to study how train passengers safely can be evacuated in case of a fire emergency. In addition to determine flow rates, the walking velocity and wal

Linear pi-conjugated oligomers have been widely investigated, but the behavior of the corresponding cyclic oligomers is poorly understood, despite the recent synthesis of pi-conjugated macrocycles such as [n]cycloparaphenylenes and cyclo[n]thiophenes. Here we present an efficient template-directed synthesis of a pi-conjugated butadiyne-linked cyclic porphyrin hexamer directly from the monomer. Sma

This paper complements the other papers in the Lancet Series on midwifery by documenting the experience of low-income and middle-income countries that deployed midwives as one of the core constituents of their strategy to improve maternal and newborn health. It examines the constellation of various diverse health-system strengthening interventions deployed by Burkina Faso, Cambodia, Indonesia, and

Phosphor thermometry is applied for the first time in a large-bore two-stroke diesel engine. The work proves the practicality of phosphor thermometry in large-bore engines. The experiments were conducted on the MAN 4T50ME-X marine research engine equipped with an optical cylinder head. By employing a thin surface coating of CdWO4 phosphor, cycle resolved temperature measurements of the cylinder wa

BOOK SYNOPSIS: Throughout the industrialised world trade unionists are reforming their organisations as part of a strategy to adjust to new labour market, economic and political circumstances. This volume examines the role of merger activity in this process of reform. The book identifies the pattern of merger activity, the factors that promote its development and its impact on union structure and

Microelectronics promises a high component density and low power dissipation to embedded systems. Unfortunately such a component will always suffer from various error types that make the chip respond differently from its functional simulation. This is especially true for Cellular Neural Networks (CNN), which makes the determination of robust, low-precision parameters to guarantee small footprint a

The proper handling of alarms is crucial to automated process control. In practice, many alarms are only distractive and do not represent a fault situation. Here a toolbox, that uses an expert system called LARA, is proposed that aims to reduce the occurrence of so-called nuisance alarms. It is based on a signal classification scheme to propose suitable alarm handling algorithms according to the s

Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However, COX-2 is also constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution that includes the kidney, gastrointestinal tract, brain, and thymus. Constitutive COX-2 expression is therapeuti

Background Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide polymorphisms (SNPs) associated with coronary heart disease. We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design. Methods We tested 13 recently discovered SNPs for a

The stabilization characteristics and local extinction structures of partially premixed methane/air flames were studied using simultaneous OH-PLIF/PIV techniques, and large eddy simulations employing a two-scalar flamelet model. Partial premixing was made in a mixing chamber comprised of two concentric tubes, where the degree of partial premixing of fuel and air was controlled by varying the mixin

Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass

Aims: Skeletal muscle is a major metabolic organ and plays important roles in glucose metabolism, insulin sensitivity and insulin action. Muscle telomere length reflects the myocyte's exposure to harmful environmental factors. Leukocyte telomere length is considered a marker of muscle telomere length and is used in epidemiologic studies to assess associations with ageing-related diseases where mus

Drawing from socio-legal studies on technological governance and notions of the pacing problem between law and new technologies, this chapter addresses how generative AI is regulated in the EU AI Act. Specifically, it focuses on implications of the two-tiered approach to General Purpose Artificial intelligence (GPAI) models, where the top tier is adding obligations to producers of so-called “syste

This paper presents a two-phase heuristic methodology aimed at the reconfiguration of a radial distribution network with the objective of minimizing the computational time. In the preliminary phase of the operation, all network switches are in a closed state, and it is proposed that a subsequent switch opening methodology be employed to achieve a configuration that approximates optimal radial char

The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify the sequence variants that are able to account for the disease association, we resequenced the genes IKBKE and IFIH1. Eighty-six single-nucleotide variants (SNVs) with potentially functional effect or differences in allele frequencies between patients and controls dete

Problemställning: Idag utgör byggnader 40 % av den Europeiska unionens sammanlagda energianvändning. Europaparlamentets och rådets direktiv 2010/31/EU antogs den 19 maj 2010, vilket verkar för att öka användningen av förnybara energikällor och samtidigt minska energianvändningen. Direktivet beskriver att medlems-staterna ska ta ansvar för att alla nya byggnader är nära-nollenergibyggnader senast Question: Today, buildings are responsible for 40 % of the total energy consumption in the Union. Directive 2010/31/EU of the European Parliament and Council was adopted May 19th of 2010 whose purpose is to increase the usage of energy from renewable sources and to reduce energy consumption. Article 9 states that by December 31st of 2020, all new buildings are supposed to be nearly zero-energy bu

Recombinant antibody libraries can provide a source of renewable and high-performing binders tailored for use in affinity proteomics. In this context, the process of generating site-specific 1:1 tagging/functionalization and/or orientated surface immobilization of antibodies has, however, proved to be challenging. Hence, novel ways of generating such engineered antibodies for use in affinity prote

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE a