Filtyp
In this paper, we present a study for the identification of authors’ national variety of English in texts from social media. In data from Facebook and Twitter, information about the author’s social profile is annotated, and the national English variety (US, UK, AUS, CAN, NNS) that each author uses is attributed. We tested four feature types: formal linguistic features, POS features, lexicon-based
Second mitochondria-derived activator of caspase (SMAC) mimetics (SMs) are selective antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-B signaling and promote tumor cell death. Through gene expression analysis, we found that treatment of CD4+ T cells with SMs during T helper 17 (TH17) cell differentiation disrupted the balance between two antagonistic transc
The rapid development of new therapies in metastatic breast cancer (MBC), entails a need for improved prognostic and monitoring tools. Thymidine kinase 1 (TK1) is involved in DNA synthesis and its activity correlates to outcome in cancer patients. The aim of this study was to evaluate serum TK1 activity (sTK1) levels in MBC patients as a tool for prognostication and treatment monitoring. 142 women
Although natural products are an important source of drugs and drug leads, identification and validation of their target proteins have proven difficult. Here, we report the development of a systematic strategy for target identification and validation employing drug affinity responsive target stability (DARTS) and mass spectrometry imaging (MSI) without modifying or labeling natural compounds. Thro
CD47, also known as integrin-associated protein (IAP), is a transmembrane protein with multiple biological functions including regulation of efferocytosis and leukocyte trafficking. In this study we investigated the effect of CD47-deficiency on atherosclerosis using a model of adeno-associated virus (AAV)-induced hypercholesterolemia. We observed increased plaque formation in CD47 null mice compar
The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mitochondrial proteome in human isogenic induced pluripotent stem cell-derived neurons with and withou
Is there a universal hierarchy of the senses, such that some senses (e.g., vision) are more accessible to consciousness and linguistic description than others (e.g., smell)? The long-standing presumption in Western thought has been that vision and audition are more objective than the other senses, serving as the basis of knowledge and understanding, whereas touch, taste, and smell are crude and of
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. The aim of the present study was therefore to investigate the inter-individual variation in complement activit
In this contribution, we report about tomographic nanoscale imaging using a laser-produced plasma-based laboratory transmission X-ray microscope (LTXM) in the water window. The soft X-ray radiation of the LTXM is provided by a high average power laser-produced (1.3 kHz repetition rate, 0.5 ns pulse duration, 140 W average power) plasma source, a multilayer condenser mirror, an objective zone plate
BACKGROUND: The release of neuron-specific astroglial S-100 protein to the cerebrospinal fluid is a marker of cerebral damage. The aim of this study was to determine the pattern of release of S-100 protein to serum after pediatric cardiac operations and extracorporeal circulation.METHODS: Sequential blood samples from 97 children (up to 16 years) were taken after induction of anesthesia, immediate
BACKGROUND: Thylakoid-stabilised emulsions have been reported to possess satiety-promoting effects and inhibit pancreatic lipase-colipase activity in vitro, which prompted the investigation of their interfacial properties.RESULTS: Thylakoid membranes isolated from spinach were used as an emulsifier/stabiliser in oil (triglyceride)-in-water emulsions. Emulsions were characterised with respect to dr
Partitioning large high-speed globally synchronous ASICs into locally clocked blocks reduces clock skew problems and if handled correctly it also reduces the power consumption. However, to achieve these positive effects, the blocks need on-chip clock generators having properties such as small area and low power consumption. Therefore, a low power, high frequency, small area digitally controlled on
Objectives This study investigated the association between cancer of the extrahepatic biliary tract and exposure to endocrine-disrupting compounds. Methods Altogether 183 men with histologically confirmed carcinoma of the extrahepatic biliary tract and 1938 matched controls were interviewed between 1995 and 1997 in the frame of an international multicenter case-control study in six European countr
The complement system is activated in the vasculature during thrombotic and inflammatory conditions. Activation may be associated with chronic inflammation on the endothelial surface leading to complement deposition. Complement mutations allow uninhibited complement activation to occur on platelets, neutrophils, monocytes, and aggregates thereof, as well as on red blood cells and endothelial cells
Popular Abstract in Swedish Kontaktallergi är en vanlig orsak till eksem i arbetslivet. Ett av de viktigaste arbetsrelaterade allergenen är epoxiharts. Det allergiframkallande ämnet i det vanligaste epoxihartset visades på 1970-talet vara det ämne, diglycidyleter av bisfenol A (DGEBA), som hartset är uppbyggt av. Dessa epoxihartser är sedan decennier med i den standardserie med allergiframkallandeEpoxy resins based on bisphenol A are well-known contact allergens and often cause occupational contact allergy. The most important allergen is the monomer diglycidyl ether of bisphenol A (DGEBA). Epoxy resins of the bisphenol F-type contain 3 isomers of the diglycidyl ether of bisphenol F; p,p'-DGEBF, o,p'-DGEBF, and o,o'-DGEBF, whereas epoxy resin(s) based on bisphenol A (DGEBA-R) contain virtua
The purpose of the paper is to apply system identification methods to study spatial and temporal propagation of atrial activation along coronary sinus (situated in the posterior left part of the heart, in the groove between left atrium and left ventricle) during paroxysmal atrial fibrillation using data recorded from 7 different patients. Furthermore, interatrial mechanisms of impulse conduction c
