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Autoantibodies to insulin are often the first autoantibodies detected in young children with type 1 diabetes and can be present before the onset of clinical diabetes. These autoantibodies and their epitopes are, however, not well characterized. We explored the use of monoclonal antibodies and their recombinant Fab as reagents for epitope analysis. In this study we cloned and characterized the reco
Aggregation-prone proteins have been suggested to overwhelm and impair the ubiquitin/proteasome system (UPS) in polyglutamine (polyQ) disorders, such as Huntington's disease (HD). Overexpression of an N-terminal fragment of mutant huntingtin (N-mutHtt), an aggregation-prone polyQ protein responsible for HD, obstructs the UPS in cellular models. Furthermore, based on the accumulation of polyubiquit
The 7th Ammendment to the Cosmetics Directive of the European Commission (Directive 76/768/EEC2) bans the marketing of cosmetics containing animal-tested ingredients since March 2009. Excepted are only tests for repeated dose toxicity, for which the animal ban will come into effect by 2013. One major concern for cosmetics, i.e. the risk of containing skin (contact) sensitizers, has in the past bee
Debt and equity are in most countries treated differently for taxing purposes. The asymmetry between the financing forms are being taken advantage of by MNEs, allowing them to plan their cross-border activities in a way that lowers the taxable burden for the whole group. To prevent the increasing problem of base erosion and profit shifting, Member States have implemented different rules limiting i
Uppsatsens syfte är att studera manlig prostitution så som den framträder i svensk dagspress mellan åren 1993-2013 och därvid jämföra manlig heterosexuell respektive homosexuell prostitution. De frågeställningar som undersöks är vilken bild som framträder för dessa grupper, vilka likheter och skillnader som finns mellan dem samt vilken förklaring Connell och Hirdmans genusteori skulle ge till dessPurpose of this thesis is to study male prostitution as it emerges in Swedish newspapers between the years 1993-2013 , comparing male heterosexual and homosexual prostitution. The issues examined is the picture that emerges for these groups , what similarities and differences between them and what explanation Connell and Hird 's gender theory would give to these potential differences . To inve
During the fall of 2023, the Palestine solidarity movement grew as a response to Israel’s war on Gaza. The student movement for Palestine was an important part of the Palestine solidarity movement. Palestinagård demanded LU to comply with their demands: to stand in solidarity with Palestine and Israel’s systemic destruction of the education system (scholasticide), cut ties with complicit academic
This study explores the potential of new building insulation material specifically wood wool in Bhutanese Buildings. To cover social and performance-related aspects a quantitative and semi-structured qualitative interview study about the perception of current construction quality and methods and new building materials was conducted as well as a simulation study with different renovation scenarios.
Whilst innate B1-B cells are atheroprotective, adaptive B2-B cells are considered pro-atherogenic. Different subsets of B regulatory cells (B-reg) have been described. In experimental arthritis and lupus-like disease, B-reg are contained within the CD21(hi)CD23(hi)CD24(hi) B cell pool The existence and role of B-reg in vascular disease is not known. We sought to investigate the existence, identity
A 37-year-old female subject had been convicted of driving under the influence of alcohol, and 19 months later, claimed abstinence after supervised disulfiram treatment. Our aim was to elucidate the value of direct ethanol metabolites as measures of abstinence. Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE) in hair, phosphatidylethanol in whole blood and EtG and ethyl sulphate in urine
We proposed a 4×8 array antenna with aperture-coupled patch antenna elements. The antenna was designed for 60 GHz operation and fabrication on the low-temperature cofired ceramic(LTCC) substrate(εr=5.8). The feedline with the stub was designed to enhance the radiating element bandwidth and the transition characteristics between the waveguide (WG) and microstrip line(MSL). Through the optimization
T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. Naïve CD4+ and CD8+ T cells activation takes place in lymphoid organs after recognition of cognate antigen in the context of major hi
Background: Potato late blight caused by the oomycete pathogen Phytophthora infestans can lead to immense yield loss. We investigated the transcriptome of Solanum tubersoum (cv. Desiree) and characterized the secretome by quantitative proteomics after foliar application of the protective agent phosphite. We also studied the distribution of phosphite in planta after application and tested transgeni
The purpose of this essay is to present the conclusions and recommendations in the Goldstone report that were given to the state of Israel, as well as presenting the state of Israel’s response and presented investigations against the allegations. Along with that, a presentation of Amnesty International’s updated assessment will be given along with its criticism towards the state of Israel due to t
Sweden’s civil society is changing. The democratic civil organization, a symbol of the ideologically intertwined popular movement with its historical strive toward the welfare state, is increasingly adopting the concepts, resources and organizational models of the corporation. By challenging the member-run and altruistic ideals of the civil sector the process of corporatization is perceived as a t
The dissertation explores the relationship between Aby Warburg’s unfinished picture atlas Mnemosyne and the visualization of Art History around 1800/1900 in an attempt to understand the historical conditions regarding the picture atlas and other visual devices constructed by Warburg and his staff at the Kulturwissenschaftlichen Bibliothek Warburg (K.B.W.) in Hamburg during the 1920s. The dissertat
The main objective was to compare short wave radiation from Thorn lamp to solar radiation. In sun all manikin front zones get more or less evenly radiated but in the lab the radiated power reaches some zones more than others. Tests were carried out on the thermal manikin Tore under clear sky in a building corner facing the sun. The manikin was turned so that in the end of each trial the sun faced
Computer-based design analysis is nowadays a common activity in most development projects. Used for design evaluation, verification, validation, or as a support for design exploration, it fulfils an important support function for the engineering designer, thus making it essential to have an operationally efficient and effective integration between both the engineering design and design analysis ac
BACKGROUND: Heart failure (HF) is characterized by hemodynamic derangements that are likely to mediate systemic metabolic perturbations but limited data are available. Plasma metabolite profiling provides opportunities for comprehensive investigation of such perturbations. Here, we aimed to characterize plasma profiles that associate with HF and their relationship with central hemodynamics, sympto
