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Reliable assessment of self-reported immune function is essential for identifying at-risk populations, monitoring public health interventions and informing global health strategies. Yet, current instruments are imprecise and lack cross-cultural validity. This study aimed to assess the cross-cultural validity of the 7-item Immune Status Questionnaire (ISQ). The Partial Credit Rasch model was applie
In vivo gene transfer using viral vectors is an emerging therapy for neurodegenerative diseases with a clinical impact recently demonstrated in Parkinson's disease patients. Recombinant adeno-associated viral (rAAV) vectors, in particular, provide an excellent tool for long-term expression of therapeutic genes in the brain. Here we used the [C-11] raclopride [(S)-(-)-3,5-dichloro-N-((1-ethyl-2-pyr
Several stilbenoid compounds having structural similarity to the combretastatin group of natural products and characterized by the incorporation of two nitrogen-bearing groups (amine, nitro, serinamide) have been prepared by chemical synthesis and evaluated in terms of biochemical and biological activity. The 2',3'-diamino B-ring analogue 17 demonstrated remarkable cytotoxicity against selected hu
Context:Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective:The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants:The des
In the female turnip moth, Agrotis segetum, a pheromone biosynthesis activating neuropeptide (PBAN) stimulates sex pheromone biosynthesis which exhibits a daily rhythm. Here we show data supporting a circadian rhythm in PBAN release from the corpora cardiaca, which we propose regulates the endogenous rhythm in sex pheromone biosynthesis. This conclusion is drawn as the observed daily rhythm in PBA
Popular Abstract in Swedish Syftet med avhandlingen är att diskutera de två antropologiska koncepten mikrokosmos och förvaltare var för sig i anslutning till Kyrkornas Världsråds så kallade JPIC-process, där JPIC står för ”justice”, ”peace” och ”the integrity of creation”, samt att slutligen med hjälp av en teologisk korrelationsmetod relatera de båda koncepten till varandra. Inledningskapitlet beThe aim of this dissertation is to discuss the two theologic anthropological concepts microcosm and steward within the World Council of Churches project called the JPIC-process - their JPIC stands for justice, peace and the integrity of creation - and to relate the two anthropological concepts to each other using a theological correlation method. After an introduction the JPIC-process, which offic
In this paper we discuss the dynamic nature of mobile usage, and how this impacts on design and evaluation, particularly in an industrial setting. We argue that current industry oriented design tools need to be extended to cater more effectively to the highly dynamic and context-dependent nature of mobile usage -- we suggest more focus should be put on doing instead of on being. In order to achiev
Popular Abstract in Swedish Membranproteiner är tämligen svåra att digerera med enzym som trypsin. Mindre specifika enzym såsom elastase och pepsin har dock visat sig mer effektiva. Databassökningar med dessa icke-tryptiska peptider är mindre verkningsfulla pga avsaknaden av laddning vid peptidens N-terminal och C-terminal samt brist på sekvensspecificitet. Vi beskriver en metod med specifik N-teMembrane proteins are fairly refractory to digestion especially by trypsin. Less specific proteases like elastase and pepsin are much more effective. However database searching using non-tryptic peptides is much less effective due to the lack of charge localisation at the N- and C-termini and the absence of sequence specificity. We describe a method for N-terminal specific labelling of peptides fr
Popular Abstract in Swedish Bomärken har använts som ägarbeteckning och signatur i Norden in på 1800-talet, och i vissa reliktområden intill nutid. Bomärkena återfinns t.ex. i mantalslängder, jordaböcker och bouppteckningar, men även inskurna på äldre redskap, husgeråd och annat lösöre. Bomärkena har av somliga forskare ansetts ha utformats slumpvis, enbart med syftet att kunna skilja en bomärkesThe pioneering academic research on Merchant Marks (also known as identity marks, personal marks, ownership marks, identification marks, Hausmarken, Hofmarken, Marques de Propriété, bomärken) was done by professor Homeyer (1870). Since 1870 there has been an ongoing debate among scholars whether Merchant Marks are simply formed by chance and coincidence, as stated by Rehnberg (1938, 1951), Scheffe
Popular Abstract in Swedish Denna studie betonar att de mekanismer, som skapar tillväxt, inte nödvändigtvis är universella utan kan skilja sig åt mellan olika områden, beroende på vad som produceras och vilken teknik som används. Avhandlingen hävdar inledningsvis att ekonomisk tillväxt är den viktigaste enskilda faktor som påverkar individers inkomstnivå och att ökad produktivitet i sin tur är gruThis study shows that the mechanisms behind knowledge accumulation and the sources of productivity growth differ from industry to industry depending on what is produced and what technology is used. Although it is apparent to most researchers in the field that the only way to explain long-run growth in output per capita is through technological progress and accumulation of knowledge that counteract
The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function. We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice. In alpha E-/- mice, intestinal and vaginal IEL numbers were reduced, consistent with the known binding of alpha E beta 7 to E-
The ion photon emission microscope, or IPEM, is the first device that allows scientists to microscopically study the effects of single ions in air on semiconductors, microchips and even biological cells without having to focus the beam. Reported here is a prototype, the size of a conventional optical microscope, developed at Sandia. The alpha-IPEM, that employs alpha particles from a radioactive s
Avhandlingen omfattar fyra delarbeten av olika slag, där två är rent laborativa studier av odlade Leishmaniaparasiter och deras interaktion med humant immunsvar, och två berör epidemiologi och diagnostik av sjukdomen leishmaniasis i ett svenskt patientmaterial.This doctoral thesis consists of four separate papers, in which we; investigate epidemiological and clinical aspects of leishmaniasis in Sweden in order to increase awareness of the disease, elucidate some aspects of the interaction of the parasite and the human immune system and validate serological tools as a complement for diagnosis of leishmaniasis.
Neutrophils play a crucial role in host defense. However, neutrophil activation is also linked to autoimmune diseases such as systemic lupus erythematosus (SLE), where nucleic acid-containing immune complexes (IC) drive inflammation. The role of Toll-like receptor (TLR) signaling in processing of SLE ICs and downstream inflammatory neutrophil effector functions is not known. We observed that TLR7/
Antibody responses induced at mucosal and nonmucosal sites demonstrate a significant level of autonomy. Here, we demonstrate a key role for mucosal interferon regulatory factor-4 (IRF4)-dependent CD103 + CD11b + (DP), classical dendritic cells (cDCs) in the induction of T-dependent immunoglobulin G (IgG) and immunoglobulin A (IgA) responses in the mesenteric lymph node (MLN) following systemic imm
