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BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences.METHODS: We performed a meta
After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characteriz
Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Because of the hyperacute lethality, it is possible that the role of GzmB was concealed by the system. There
BACKGROUND: In Phase II/III trials, administration of quadrivalent human papillomavirus (HPV) (types 6/11/16/18) L1 virus-like-particle vaccine was highly effective in preventing HPV6/11/16/18-related cervical intraepithelial neoplasia and non-invasive cervical cancer in women aged 16-26 years who were naïve to these HPV types at enrollment. However, the makeup and extent of catch-up vaccination p
Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screeni
The electron-ion scattering experiment ELISe is part of the installations envisaged at the new experimental storage ring at the International Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It offers an unique opportunity to use electrons as probe in investigations of the structure of exotic nuclei. The conceptual design and the scientific challenges of ELISe are presented.
Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunizati
Background: Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. Methods: We performed a matched case-control study on 1311 pairs of women with known deleterious BRCA1
Popular Abstract in Swedish 1997 ökade långtidssjukskrivningarna i Sverige, vilka fortsatte att öka till och med 2002. Vanligtvis förklaras ökningen med orsaker på individnivå eller i arbetsmiljön. Genom att avgränsa avhandlingen till långtidssjukskrivningar bland arbetslösa, hamnar en annan förståelse i fokus, sammanfattad som att välfärdsstater utvecklar dold arbetslöshet bland dem med begränsadIn 1997 the number of long-term absences due to illness began and continued to rise in Sweden. Traditional explanations of why this is so have been centered on either blaming the individual or blaming the work environment. By focusing on long-term illness of the unemployed, this dissertation suggests that there is a growing residual unemployment within advanced welfare states. The main question th
We analysed 68 candidate planetary systems first identified during Campaigns 5 and 6 (C5 and C6) of the NASA K2 mission. We set out to validate these systems by using a suite of follow-up observations, including adaptive optics, speckle imaging, and reconnaissance spectroscopy. The overlap between C5 with C16 and C18, and C6 with C17, yields light curves with long baselines that allow us to measur
Source-separating sanitation systems offer the possibility of recycling nutrients present in wastewater as crop fertilisers. Thereby, they can reduce agriculture's impacts on global sources, sinks, and cycles for nitrogen and phosphorous, as well as their associated environmental costs. However, it has been broadly assumed that people would be reluctant to perform the new sanitation behaviours tha
Uncertainty Regarding Waste Handling in Everyday Life Sustainability 2010, 2, 2799-2813; doi:10.3390/su2092799 sustainability ISSN 2071-1050 www.mdpi.com/journal/sustainability Article Uncertainty Regarding Waste Handling in Everyday Life Greger Henriksson 1, *, Lynn Åkesson 2 and Susanne Ewert 2 1 Department of Urban Planning and Environment, KTH Royal Institute of Technology, Drottning Kristinas
Master’s Dissertation Structural Mechanics Report TV SM -5209 M A TTIA S LILJA IN TER A C TIV E STR U C TU R A L A N A LY SIS FO R TH E C O N C EPTU A L D ESIG N PH A SE MATTIAS LILJA INTERACTIVE STRUCTURAL ANALYSIS FOR THE CONCEPTUAL DESIGN PHASE DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--16/5209--SE (1-55) | ISSN 0281-6679 MASTER’S DISSERTATION Supervi
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5209.pdf - 2026-05-28
Löneavtal Unionen - Akademikerförbunden 2020-12-01-2020-04-30 LÖNEAVTAL Tjänstemän 2020-12-01–2023-04-30 Akademikerförbunden har i förhandlingarna företrätts av Akavia. Akavia uppträder under innevarande avtalsperiod som gemensam representant för Akademikerförbunden. Central förhandling, vanligtvis efter lokal förhandling enligt MBL §§ 10-12, begärs hos eller av Akavia oberoende av om berörd perso
Statul de Drept Un ghid pentru politicieni 2 Copyright © Institutul Raoul Wallenberg pentru Drepturile Omului şi Drept Umanitar şi Institutul de la Haga pentru Internaţionalizarea Dreptului 2012 ISBN: 978-91-86910-95-2 Această publicaţie este difuzată cu condiţia de a nu fi împrumutată, vândută sau închiriată în scop comercial, şi de a fi difuzată numai cu consimţământul dat în prealabil de către
https://rwi.lu.se/app/uploads/2013/04/Statul-de-Drept.pdf - 2026-05-29
