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Validation of Risk Scoring Systems in Ursodeoxycholic Acid-Treated Patients With Primary Biliary Cholangitis

INTRODUCTION: Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed for risk prediction in PBC, but these have not been validated in large external cohorts. METHODS: We performed a study on data of 1746 UDCA-treated

The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross.

The non-obese diabetic (NOD) mouse spontaneously develops diabetes and sialadenitis. The sialadenitis is characterized by histopathological changes in salivary glands and functional deficit similar to Sjögren's syndrome. In humans, Sjögren's syndrome could be associated with other connective tissue disorders, such as rheumatoid arthritis. In the present study the genetic control of sialadenitis in

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus

A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using mathematical models to identify early somatic genetic deletions in tumor tissues followed by targeted linkage analysis. Comparative genomic hybridization was used to study 61 breast tumors from 37 breast c

Tumor attenuation by combined heparan sulfate and polyamine depletion.

Cells depend on polyamines for growth and their depletion represents a strategy for the treatment of cancer. Polyamines assemble de novo through a pathway sensitive to the inhibitor, alpha-difluoromethylornithine (DFMO). However, the presence of cell-surface heparan sulfate proteoglycans may provide a salvage pathway for uptake of circulating polyamines, thereby sparing cells from the cytostatic e

Prevalence and clinical correlations of antibodies against six beta 2-glycoprotein-I-related peptides in the antiphospholipid syndrome

Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-beta2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-beta2GPI peptide antibody. The rates of the various antipeptides Abs ranged fr

Human papillomavirus and Papanicolaou tests to screen for cervical cancer.

Background Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or cervical cancer is unknown. Methods In a population-based screening program in Sweden,

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 8377 breast cancer patients

Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAT-1 are associated with poor prognosis in breast cancer patients. To confirm the prognostic value of uPA and PAI-1 in primary breast cancer, we reanalyzed individual patient data provided by members of the European Organization for Re

The GALAH survey : A new constraint on cosmological lithium and Galactic lithium evolution from warm dwarf stars

Lithium depletion and enrichment in the cosmos is not yet well understood. To help tighten constraints on stellar and Galactic evolution models, we present the largest high-resolution analysis of Li abundances A(Li) to date, with results for over $100\, 000$ GALAH (Galactic Archeology with HERMES) field stars spanning effective temperatures $5900\, \mathrm{K} \lesssim T_{\mathrm{eff}}\lesssim 7000

CKD : A Call for an Age-Adapted Definition

Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m2 This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that G

The American Business Judgment Rule and Swedish Law - A Comparative Analysis of the American Business Judgment Rule and Its Eventual Counterpart in Swedish Law

Syftet med den här uppsatsen är att undersöka huruvida svenska styrelseledamöter och verkställande direktörer kan förvänta sig att de svenska domstolarna prövar affärsbeslut på ett liknande sätt som de amerikanska domstolarna prövar affärsbeslut. Undersökningen möjliggör en komparativrättslig analys av huruvida det finns något i svensk rätt som liknar den i amerikansk rätt existerande BJR, vilket The purpose of this thesis is to examine whether Swedish directors and CEOs can expect the Swedish courts to review business decisions in a similar way to how the American courts review business decisions. This examination enables a comparative analysis of whether something similar to the American business judgment rule exists in Swedish law, which some Swedish legal scholars claim. The American

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COSM23 Contemporary Chinese Society Literature List Spring Semester 2026 Approved on 18 November 2026 by the education board at the Centre for East and South-East Asian Studies. Introduction In 2026, COSM23 will require students to read 438 pages of book chapters and approximately 1038 pages of journal articles, policy documents, and expert popular discourse. In addition, student will select about

https://www.ht.lu.se/media/utbildning/dokument/kurser/COSM23/20261/COSM23_2026_literature_list.docx - 2026-05-21

Interdisciplinary pedagogy in

Interdisciplinary pedagogy in Interdisciplinary pedagogy in higher education Proceedings from Lund University’s Teaching and Learning Conference 2019 EDITORS: JOHANNA BERGQVIST RYDÉN, ANNE JERNECK, JESSIKA LUTH RICHTER & KARIN STEEN LUND UNIVERSITY 1 Interdisciplinary pedagogy in higher education Proceedings from Lund University's Teaching and Learning Conference 2019 Editors: Johanna Bergqvist Ry

https://www.ahu.lu.se/fileadmin/user_upload/ahu/PDF/Proceedings_Interdisciplinary_pedagogy_in_higher_education_Lund_University_2019.pdf - 2026-05-28

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Examdatum poang f_namn01 f_namn02 uppsatstitel w_namn01 w_namn02 verktitel w2_namn0 1 w2_namn0 2 typ niva handledare efternamn nyckelord inriktning 1971-05-30 7.5 Gunnel Danielsson Nadine Gordimer´s Novels With Particular Reference to Racial Relations Nadine Gordimer Novels Novel A80 Claes Schaars Characterisation Literature 1972-05-24 7.5 Eva Jarring An Analysis of James Baldwin´s Another Country

https://www.sol.lu.se/fileadmin/_migrated/content_uploads/engelskans_gamla_uppsatser.pdf - 2026-05-28

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Division of Solid Mechanics Martin Norlander For information please contact: Division of Solid Mechanics, Lund University, Box 118, 221 00 Lund Homepage: www.solid.lth.se CRACK PROPAGATION IN FIXED CALLIPER BRAKE DISCS Master’s Dissertation M artin N o rlan d er C rack p ro p ag atio n in fixed callip er b rake d iscs Department of Mechanical Engineering Solid Mechanics ISRN LUTFD2/TFHF-05/5110-SE

https://www.solid.lth.se/fileadmin/hallfasthetslara/utbildning/examensarbete/TFHF5110.pdf - 2026-05-28

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COSM23 Contemporary Chinese Society Literature List Spring Semester 2026 Approved on 18 November 2026 by the education board at the Centre for East and South-East Asian Studies. Introduction In 2026, COSM23 will require students to read 438 pages of book chapters and approximately 1038 pages of journal articles, policy documents, and expert popular discourse. In addition, student will select about

https://www.historiska.lu.se/media/utbildning/dokument/kurser/COSM23/20261/COSM23_2026_literature_list.docx - 2026-05-28

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Get a grip of your a guide to competence and career development Preface A company is no better than its collective competence. Your and your colleagues' knowledge, experience and ability to translate these competencies are therefore completely fundamental to Scania's success. At the same time, technological development is faster than ever. In order to be at the forefront, we need to constantly bui

https://www.saco.se/globalassets/lokala-akademikerforeningar/privat/scania/dokument/get_a_grip_of_your_career_v6_interactive.pdf - 2026-05-29

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2

Certified reference material for radionuclides in fish flesh sample IAEA-414 (mixed fish from the Irish Sea and North Sea)

A certified reference material (CRM) for radionuclides in fish sample IAEA-414 (mixed fish from the Irish Sea and North Seas) is described and the results of the certification process are presented. Nine radionuclides (K-40, Cs-137, Th-232, U-234, U-235, U-238, Pu-238, Pu239+240 and Am-241) were certified for this material. Information on massic activities with 95% confidence intervals is given fo