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We investigate the population of high-redshift (3≤z < 6) active galactic nuclei (AGN) selected in the two deepest X-ray surveys, the 7 Ms Chandra Deep Field-South and 2 Ms Chandra Deep Field-North. Their outstanding sensitivity and spectral characterization of faint sources allow us to focus on the sub-L* regime (logLX ≲ 44), poorly sampled by previous works using shallower data, and the obscured

Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme of Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label ascending-dose study in highly sensitized patients with chronic kidney disease. Eight patients with cytotoxic PRAs (median cytotoxic PRAs of 64%) at enrollment received 1 or 2 intravenous infusions of IdeS on consecutive days

The identification of jets containing b hadrons is important for the physics programme of the ATLAS experiment at the Large Hadron Collider. Several algorithms to identify jets containing b hadrons are described, ranging from those based on the reconstruction of an inclusive secondary vertex or the presence of tracks with large impact parameters to combined tagging algorithms making use of multi-v

Pb-based perovskite absorbers with organic (i.e., CH3NH3+) and inorganic (i.e., Cs+) cations and a halide composition of 75% Br and 25% I are investigated with x-ray photoelectron spectroscopy while submitted to environmental stress factors to study their stability. Changes in chemical properties of the absorbers were monitored in ultra-high vacuum and under simulated solar, as well as, x-ray irra

Background: A childhood cancer diagnosis and treatment-induced somatic late effects can affect the long-term mental health of survivors. We aimed to explore whether childhood cancer survivors are at higher risk of psychiatric disorders later in life than their siblings and the general population. Methods: In this register-based cohort study (part of the Socioeconomic Consequences in Adult Life aft

OBJECTIVE: This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. METHODS: The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and treatment in people wit

PURPOSE: We performed an exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer receiving apalutamide (240 mg/day) or placebo, with continuous androgen deprivation therapy (ADT), in the phase 3, randomized, double-blind, placebo controlled TITAN trial (NCT02489318). MATERIALS AND METHODS: P

Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. The aim of this study was to characterize novel patterns of immune cell infiltration in non-small cell lung cancer (NSCLC) in relation to its molecular and clinicopathologic characteristics. Lymphocytes (CD3+, CD4+, CD8+, CD20+, FOXP3+, CD45RO+), macrophages (CD163+), plasma cells (CD138+), NK cells (NKp4

Background: Vascular-targeted photodynamic therapy, a novel tissue-preserving treatment for low-risk prostate cancer, has shown favourable safety and efficacy results in single-arm phase 1 and 2 studies. We compared this treatment with the standard of care, active surveillance, in men with low-risk prostate cancer in a phase 3 trial. Methods: This randomised controlled trial was done in 47 Europea

We apply the twin method to determine parallaxes to 232 545 stars of the RAVE survey using the parallaxes of Gaia DR1 as a reference. To search for twins in this large data set, we apply the t-student stochastic neighbour embedding projection that distributes the data according to their spectral morphology on a two-dimensional map. From this map, we choose the twin candidates for which we calculat

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draini

Uppsatsen handlar om vilka faktorer det är som gör att förvaltningsbeslut och förvaltningsmål karaktäriseras som tviste- eller brottmålsliknande. Denna karaktärisering leder i sin tur till att förvaltningsbeslutet eller förvaltningsdomen vinner negativ rättskraft så hinder föreligger för ny prövning av samma sak. Myndighetsbeslut och förvaltningsdomar vinner som huvudregel inte negativ rättskraftThis note analyzes the factors that determine whether administrative decisions and opinions are characterized as civil proceedings or criminal proceedings. This characterization, in turn, determines whether the prohibition on double jeopardy (so called “legal force”) applies, so that there is a barrier to a new trial of the same issue. In the paper, the rules on enforceability are the same in the

Human rights are the basis by which the dignity of the human being is guaranteed. This is especially important in the relationship between persons and governments, who on the one hand have great power in form of legislation over these persons, but on the other hand must ensure the protection of human rights. A problem may arise when these two opposing forces of the State collide,1 as the individua

Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-spe

We present a detailed study of the large-scale shock front in Stephan’s Quintet, a by-product of past and ongoing interactions. Using integral-field spectroscopy from the new William Herschel Telescope Enhanced Area Velocity Explorer (WEAVE), recent 144 MHz observations from the LOFAR Two-metre Sky Survey, and archival data from the Very Large Array and JWST, we obtain new measurements of key shoc

This paper presents the observation of four-top-quark (tt¯ tt¯) production in proton-proton collisions at the LHC. The analysis is performed using an integrated luminosity of 140 fb - 1 at a centre-of-mass energy of 13 TeV collected using the ATLAS detector. Events containing two leptons with the same electric charge or at least three leptons (electrons or muons) are selected. Event kinematics are

BACKGROUND: Cerebrospinal fluid (CSF) clearance via the olfactory pathway is well-documented in animal models. However, results from in vivo human studies appear inconsistent. Studies using intrathecal (IT) Gadolinium-based contrast agents (GBCA) enhanced MRI showed minimal tracer pass-through from intracranial to extracranial olfactory regions such as the nasal mucosa. Conversely, human imaging s

Uppsatsen uppför en historisk överblick över hur En dåres försvarstal lästs och belyser hur den kritiska diskursen förändrats. Förklaringsmodellen utgår från Bourdieus fältbegrepp vilket hjälper påvisa att positioneringar inte sker naturligt utan i relation till varandra såväl som till de rum som står och gjorts lediga på det så kallade fältet. Uppsatsen undersöker läsningars förhållningssätt till

Master’s Dissertation Structural Mechanics DAVID BJURHEDE and MATS HARRYSON Report TV SM -5178 D A V ID BJU RH ED E and M A TS H A RRY SO N A CO M PA RA TIV E STU D Y O F CO U PLED A N D U N CO U PLED A N A LY SIS M ETH O D S FO R TH ERM O H Y D RA U LIC LO A D S IN PIPE SY STEM S A COMPARATIVE STUDY OF COUPLED AND UNCOUPLED ANALYSIS METHODS FOR THERMOHYDRAULIC LOADS IN PIPE SYSTEMS Detta är en to

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5178.pdf - 2026-05-28