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Ionotropic glutamate receptors are tetrameric ligand gated ion channels that mediate in ux and ef ux of metal ions in response to glutamate. Positive allosteric modulators of the ionotropic glutamate receptor 2 (GluA2) are promising lead compounds for drugs against cognitive disorders. These compounds bind within the dimeric interface formed by the receptor ligand binding domains (LBDs) attenuatin
TheEl Niño SouthernOscillation(ENSO) isEarth's dominant source of interannual climate variability, but its response to globalwarming remainshighly uncertain1.To improve ourunder standing of ENSO's sensitivity to external climate forcing, it is paramount to determine its past behaviour by using palaeoclimate data and model simulations. Palaeoclimate records show that ENSO has varied considerably si
The last Catholic archbishop of Sweden to hold residence in his see at Uppsala, Johannes Magnus (1488-1544), was the author of a major work about Swedish history: the Historia de omnibus Gothorum Sueonumque regibus. Johannes Magnus left Sweden in 1526, spent the rest of his life away from his home country and eventually died in Rome, where his work was published posthumously in 1554. One reason fo
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Genetic polymorphisms are powerful model systems to study the maintenance of diversity in nature. In some systems, polymorphisms are limited to female coloration; these are thought to have arisen as a consequence of reducing male mating harassment, commonly resulting in negative frequency-dependent selection on female color morphs. One example is the damselfly Ischnura elegans, which shows three f
Intraductal papillary mucinous neoplasm (IPMN) is one of the most common cystic neoplasms of the pancreas. It is a heterogeneous disease and can be divided into ductal types and morphological subtypes. The incidence of IPMN is increasing, likely due to the widespread use of cross-sectional imaging and a growing elderly population. IPMN poses an increasing demand on the health care system. Current
Atherosclerosis is the underlying cause for myocardal infarction, stroke and peripheral arterial disease, collectively referred to as cardiovascular diseases. These represent the major cause of death globally. Phenotypic modulationof vascular smooth muscle cells form a contractile to a synthetic state and subsequent migration into the intima, isone of the prime events that marks the genesis of ath
Introduction: Severe obstetric complications increase with the number of previous cesarean deliveries. In the Nordic countries most women have two children. We present the risk of severe obstetric complications at the delivery following a first elective or emergency cesarean and the risk by intended mode of second delivery. Material and methods: A two-year population-based data collection of sever
Formal subdivision of the Cambrian System into four series and ten stages is in progress. The base of Cambrian Stage 3 (provisional), which is conterminous with the base of Cambrian Series 2 (provisional), is expected to be placed at a horizon close to the first appearance of trilobites, which marks the onset of the largest phase of the Cambrian explosion. Conceptually, an ideal boundary position
Popular Abstract in Swedish Enzymet magnesium-kelatas katalyserar bildandet av magnesuim-protoporfyrin genom insättning av en magnesiumjon i protoporfyrin. Detta är det första unika steget i tillverkningen av klorofyll hos växter, alger och fotosyntetiska bakterier. Magnesium-kelatas är uppbyggt av tre olika proteiner som kallas I (vikt 40 kDa), D (70 kDa) och H (140 kDa). Tillsammans bildar dessaThe insertion of Mg2+ into protoporphyrin IX represents the first committed step in the chlorophyll and bacteriochlorophyll biosynthetic pathways. The reaction is catalyzed by the multisubunit enzyme Mg-chelatase, which consists of three subunits, known as I (molecular weight ~40 kDa), D (~70 kDa), and H (~140 kDa). To fully understand this first step in chlorophyll biosynthesis each protein compo
In this paper a systematic study of the surface influence on the elastic properties of nanosized iron and tungsten wires and films is performed. Single crystal defect-free nanowires and nanofilms are examined through molecular statics simulations, and the concepts of surface energy and third order elastic constants are used in an attempt to describe the elastic properties. For structures where the re
