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Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat

In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses

We introduce rigorous theory for deriving first and second order backpropagation methods for Deep Neural Networks (DNN) whilst satisfying existing theory in DNN optimization. We begin by formally defining a neural network with its respective components and state the first and second order chain rule with respect to its partial derivatives. The partial derivatives in the chain rule formula are rela

Object Shift and Event-Related Brain Potentials Mikael Rolla, Merle Hornea, Magnus Lindgrenb Department of Linguistics and Phoneticsa, Department of Psychologyb, Lund University mikael.roll@ling.lu.se 1. Introduction SWEDISH pronominal objects can either precede or follow a sentence adverb, as shown in example (1). In (1a), the pronominal object den ’it’ precedes the sentence adverb inte ’not’, wh

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_gpdb/Roll_Horne_Lindgren_CNS2007.pdf - 2026-05-14

Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. However, limitations in Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. However, limitations in

Mot smartare cellgiftsbehandling: Att förebygga behandlingsresistens vid äggstockscancer Äggstockscancer är den dödligaste gynekologiska cancertypen och kräver alltför många liv eftersom tumörer ofta blir resistenta mot behandling – särskilt mot cisplatin, vårt främsta försvar. För att rädda fler liv måste vi förstå hur denna resistens utvecklas och hur vi kan överlista den. I mitt examensarbete Ovarian cancer is the deadliest gynaecologic malignancy, with most patients diagnosed at an advanced stage and facing poor long-term survival. Resistance to cisplatin-based chemotherapy is a major clinical obstacle, yet its proteomic drivers remain poorly defined. In this study, I applied data-independent acquisition mass spectrometry with DIA-NN data processing to analyse one parental and two cis

Soils play a critical role in the carbon (C) cycle by regulating the atmospheric carbon dioxide (CO2) levels, and correspondingly the Earth’s climate. However, there are still countless questions of how biological and geochemical soil processes affect the C cycle. To be able to predict future implications on the Earth’s climate, we need to understand these processes. Globally, soils store more C tIron oxide nanoparticles are involved in several important biogeochemical processes. The interfaces between aqueous solutions and iron oxide nanoparticle surfaces are found everywhere in nature, and the chemical and microbial processes occurring at these complex interfaces control e.g. nutrient and contaminant availability and transport. Recently, it has been shown that certain ectomycorrhizal (EC

Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

Open Day Come and Visit our Idea to Product Lab! 18 November 2015, 8:30 – 16:30 Dear All, LTH recently acquired a high-end selective laser sintering system (3D printer) that forms the basis of a powerful new additive manufacturing facility at Lund University. We cordially invite you to come and visit the Idea to Product Lab get a better idea of what our 3D printing facilities can do for you! Our a

https://www.lu.se/sites/www.lu.se/files/i2p_lab_open_day.pdf - 2026-05-15

https://goteborgonline-my.sharepoint.com/personal/peter_jonsson_educ_goteborg_se/Documents/C%20e%20n%20t%20r%20a%20l%20a%20%20%20S%20a%20c%20o%20r%20å%20d%20e%20t%20%20%20i%20%20%20G%20ö%20t%20e%20b%20o%20r%20g%20s%20%20%20S%20t%20a%20d/AU/SKOT/C%20E%20N%20T%20R%20A%20L%20A%20%20%20S%20A%20C%20O%20R%20Å%20D%20E%20T%20%20%20I%20N%20F%20O%20R%20M%20E%20R%20A%20R/December%202024/www.saco.se/goteborg

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/goteborgs-stad/dokument/centrala-sacoradet-informerar/april-2025_centrala-sacoradet-informerar.pdf - 2026-05-15