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Understanding the pH sensitivity of proteins and enzymes across intracellular compartments is crucial for fundamental research. Lizatović et al. [1] aimed to design a peptide incorporating a specific amino acid to form a hexamer structure and lacking it to form a pentamer structure. Unexpectedly, two distinct structures emerged based on pH. At pH 6, a hexamer structure formed, albeit with a surpri

In an interconnected world, climate change impacts can cascade across sectors and regions, creating systemic risks. Here we analyse cascading climate change impacts on the EU, originating from outside the region, and identify critical intervention points for adaptation. Using network analysis, we integrate stakeholder-co-produced impact chains with quantitative data for 102 countries across foreig

Occupational exposure to the carcinogen hexavalent chromium [Cr(VI)] occurs during stainless steel production, welding, and chrome plating. Two sister-projects, SafeChrom and SAM-Krom, were initiated in Sweden and Denmark, respectively, to inform stakeholders, decision-makers and regulators on current occupational exposure to Cr(VI), and preventive measures prior to revision of national occupation

The manuscript is devoted to optimal control for a class of linear positive systems with linear objective function and linear constraints. The solution to the corresponding Bellman equation is a linear value function, which can be found by linear programming.

Examensarbetet utfördes i samarbete med Klarna i Giessen med syftet att utveckla en komponent i en del av en webbapplikation som hanterar autentisering. Komponenten skulle interagera med auktoriseringstjänsten försedd från Okta tillsammans med korrekt auktoriseringsflöde som en lösning för tillåten användning av webbapplikationen. Arbetet inleddes med en undersökning av webbapplikationen, bakomligThis thesis was written in collaboration with Klarna in Giessen with the purpose of developing a component to deal with authentication in a web application. The component is intended to interact with the authorization service from Okta with the correct type of authorization flow to allow or disallow access to the web application’s resources. At first, knowledge was gathered regarding the web appli

This thesis was dedicated to investigating the use of different parameter update schemes for Hidden Markov models with time-varying parameters, with an emphasis on developing alternatives to the quasi-Newton step. The focus was on applications to financial returns, using data from the S\&P-500 and the Nikkei index, and for comparison, a trial using synthetic data was also performed. Different

Death is a universal human experience, yet the ecological impact of the care and disposition of dead bodies is rarely considered, due in part to cultural taboos surrounding the physical reality of death and decomposition. If negative environmental consequences are to be limited, deathcare will need to adapt. Utilizing interviews with funeral directors from the United Kingdom, the United States and

This study examines the mechanisms behind the gender gap in equity-based start-up funding within the Information and Communication Technologies sector in Sweden and contributes to discussions on gender equality by presenting strategies for fostering inclusive access to equity-based capital. The analysis is guided by the following three research questions: (RQ 1) Does gender affect Swedish entrepre

As the life expectancy continues to increase in Sweden, with an estimated increase of 5 years for women and 6 years for men between 2024 and 2070, there is an increasing need for solutions that enables elderly people, and individuals with a need for extra safety, to live an independent and healthy life. One solution that is under development, is a mobile social alarm in the form of a watch, which

The number of people who choose e-books rather than reading traditional paper books are increasing as a result of our world becoming more digitized. Libraries need to keep up with this trend and modernize its lending procedures for their digital products. The purpose and goal of this Master thesis were to answer the questions how e-books can become more attractive to those who have not yet dared t

As global supply chains become increasingly vulnerable due to geopolitical instability, rising protectionism, and sustainability pressures, the trend of reshoring has emerged as a strategic response among multinational enterprises (MNEs). This thesis explores the drivers behind the reshoring decisions of seven Swedish MNEs and examines the entry modes (EMs) through which these firms implement thei

The importance of Disaster Risk Management (DRM) is growing as global risks increase and more actors implement DRM strategies. However, the unpredictable and complex nature of disasters and other risks makes it difficult to train DRM skills in advance. Serious games, which are games designed for educational purposes, offer a promising way to build these skills by simulating real-world challenges i

Background/Problematization: Iconic brands are the gold standard of branding and have established a central role in the consumers’ lives. Behind every iconic brand, we can find iconic products. Despite the importance of these products, iconic products are overlooked in academia. Few studies have explored the concept and there is no common definition or comprehensive framework. This is restrictive

Den bakomliggande orsaken till att islet amyloid polypeptide (IAPP) är cytotoxisk mot β-celler från bukspottkörteln tros vara prefibrillära oligomerer. Oligomererna skapas då IAPP ändrar konformation till amyloidfibriller. Förlusten av β-celler från cellklusterna har kopplats till typ II-diabetes. Ytterligare kunskap om hur man hindrar IAPP från att växla till den giftiga oligomerformen är oerhörtPrefibrillar oligomers are thought to be the “culprit” behind the cytotoxicity of islet amyloid polypeptide (IAPP) to pancreatic islet β-cells. The oligomers are generated in the process of IAPP’s conformational change into amyloid fibrils. The depletion of islet β-cells has been connected to type II diabetes. Knowledge of how to stop IAPP from switching into the cytotoxic oligomer form is of the

Det här examensarbetet utvecklar ett koncept för infästning av fenor på jetboards som inte intränger på befintliga patent. Det resulterande konceptet medför handlingsfrihet (FTO) och följaktligen tillåter produktion av fenor med originell design. FTO innebär möjligheten till att producera och sälja en produkt utan rättsligt ansvar gentemot ägare av patent. Examensarbetet presenterar och diskuterarThis master thesis generates a concept for the means of attaching fins onto jetboards without infringing on existing patents. The resulting concept establishes freedom to operate (FTO) and enables production of fins with original designs. FTO meaning the possibility of producing and selling a product without legal liability to any patent holders. The thesis further presents and discusses user need