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Popular Abstract in English Every year globally, an estimated 1.7 million women are diagnosed with breast cancer, while over half a million are killed by this disease. The principal cause of death is metastasis, which is the spreading of the cancer cells from the breast to other vital organs like the brain, liver or lungs, resulting in organ failure and subsequently death. Even though the past decMetastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecu

Heparan sulfate (HS), a substance common in the extracellular matrix on epithelial cells is present in the pancreas, lining the duct lumen. During pathological conditions, we propose that it can be shed from the ECM and bind to receptors on the cell surface, thus triggering an inflammatory response, which if excessive can cause acute pancreatitis (AP). Infusion of HS in the pancreatic duct in rats

Professional cycling combines extensive endurance training with non weight-bearing exercise, two factors often associated with lower bone mineral density (BMD). Therefore BMD was measured with dual-energy x-ray absorptiometry in 30 professional road cyclists (mean (SD) age: 29.1 (3.4) years; height: 178.5 (6.7) cm; weight: 71.3 (6.1) kg; %fat mass: 9.7 (3.2)%; (V) over dotO(2) max: 70.5 (5.5) ml .

Kaposi sarcoma (KS) is a locally aggressive endothelial tumour that is classified into 4 clinico-epidemiological forms: classic KS affecting lower limbs in elderly Mediterranean or East European men; endemic KS occurring in extremities among Equatorial African middle-aged men and children; iatrogenic KS involving lower limbs in immunosuppressive patients; and AIDS-associated (epidemic) KS observed

Environmental conditions, dispersal lags, and interactions among species are major factors structuring communities through time and across space. Ecologists have emphasized the importance of biotic interactions in determining local patterns of species association. In contrast, abiotic limits, dispersal limitation, and historical factors have commonly been invoked to explain community structure pat

Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour

Anthracyclines and taxanes are active cytotoxic drugs in the treatment of early metastatic breast cancer. It is yet unclear whether addition of capecitabine to the combination of these drugs improves the treatment outcome. Patients with advanced breast cancer were randomized to first-line chemotherapy with a combination of epirubicin (Farmorubicin(A (R))) and paclitaxel (Taxol(A (R))) alone (ET) o

The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main producer of extracellular matrix molecules such as collagen, versican, perlecan, biglycan, and decor

The two major aims of this study are (1) To test the performance of the Landscape Reconstruction Algorithm (LRA) to quantify past landscape changes using historical maps and related written sources, and (2) to use the LRA and map reconstructions for a better understanding of the origin of landscape diversity and the recent loss of species diversity. Southern Sweden, hemiboreal vegetation zone. The

This dissertation discusses aspects of the syntax of Övdalian, a variety spoken by ca. 2,500 people in the province of Dalecarlia in Sweden. Initially, an overview of the history and current status of the language of Älvdalen is given, and the focus of the dissertation is on certain syntactic phenomena that have been well studied from a comparative and diachronic perspective in other Scandinavian

Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected

Given the increasing interest in the association between exposure to air pollution and adverse health outcomes, the development of models that provide accurate spatio-temporal predictions of air pollution concentrations at small spatial scales is of great importance when assessing potential health effects of air pollution. The methodology presented here has been developed as part of the Multi-Ethn

Today, "the digital library" is the common way of describing a managed collection of information, with associated services, stored in digital formats and accessible over a network. Digital libraries have mainly been developed at research libraries, but during the last few years public libraries have started to offer similar services. The aim of this Master's thesis is to study how t

A detailed flammability evaluation of different materials used in the nuclear power industry is presented as an example of how important are physical observation and detailed analysis in the interpretation of test data. The objective is to provide different criteria that could allow the use of standard test data in fire modeling. So far most fire test data has only been used as an element for rank

Det kommunala planmonopolet tillåter våra kommuner att reglera mark- och vattenanvändningen samt hur bebyggelsen ska se ut. Detta innebär en stor frihet för kommunens sida men även ett stort ansvar att hantera bygglovsansökningar på ett ansvarsfullt sätt. Det är viktigt att kommunen på ett korrekt och legitimt sätt tar hänsyn till de lagar och regler som en bygglovsprövning innefattar. Åtgärden soMunicipalities have a planning monopoly that allows them to regulate land and water use. With this follows a responsibility to handle building permits in a responsible manner. The building measure must abide by the detailed development plan. Sometimes the building measure deviates from the plan, in such cases the Building committee of the municipality can grant a building permit with a minor devia

I uppsatsen du har framför dig undersöker jag målsägandens ansvar i förhål-lande till en tilltalads uppsåt eller oaktsamhet avseende målsägandens ofrivil-liga deltagande i en sexuell handling. Vi befinner oss alltså i de två första pa-ragraferna av brottsbalkens sjätte kapitel, 6:1 och 6:1 a BrB. Min undersök-ning kretsar dock inte framförallt kring gällande rätt utan kring hovrätternas tillämpninThis essay investigates whether the law or its practice can be said to impose on the plaintiff a responsibility in relation to the defendant’s intent or negli-gence regarding the plaintiff’s involuntary partaking in a sexual act with the defendant. We are hence located in the first two paragraphs of the sixth chap-ter in the Swedish criminal code, 6:1 and 6:1 a Brottsbalk (1962:700). My essay does

TRPA1, är en smärtreceptor på cellmembran vilken aktiveras av skadliga kemiska ämnen, som t.ex. allylisotiocyanater från senap, pepparrot och wasabi och därav kallas TRPA1 även för wasabi-receptorn. Smärta och klåda är tydliga symptom på högre aktivitet hos receptorn. Malariamyggan (Anopheles gambiae), använder denna receptor för att känna av skillnader i miljötemperaturer och receptorn spelar därAnimals monitor environmental ques by translating them into electrical signals through a depolarization of the electric potential over the cell membrane of nerve cells. A way to initiate the depolarization is through activation of receptors that are ion channels. These channels can facilitate the diffusion ions across membranes driven by the differences in concentration and electrical charge on ea

In this paper, the viability of integrating solar power with an already running wind power plant is examined. The study, conducted in cooperation with Eolus, takes place in Anneberg, Sweden, home to three wind turbines with a combined capacity of 10.8 MW. This study examines whether or not it would be profitable to integrate an additional intermittent power source to the wind power plant’s existin