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The long-term ecological interactions between fire and the composition of dominant trees and shrubs in boreal and cold temperate Fennoscandian forests are still under discussion. We hypothesized that fire-prone taxa should abound during periods and regions characterized by higher fire disturbance, while fire-intolerant taxa should dominate when and where fire activity is low. Biomass burning (BB)

BACKGROUND: Over the past decades many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma.METHODS: In this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry, were followed for up to ten years for a diagnosis of subse

Grasslands are among the most threatened terrestrial biomes, and habitat conservation alone will be insufficient to meet biodiversity goals. While restoration of indigenous grasslands is a priority, conflict with economic objectives means that incorporation of alternative habitats is necessary to offset grassland loss. With up to 800,000 km2 of land affected by mining globally, there is an opportu

Malignant rhabdoid tumour (MRT) is a childhood neoplasm of high malignancy characterised by biallelic mutation and/or loss of the epigenetic master regulator SMARCB1, accompanied by no or few other oncogenic drivers. In spite of their generally low mutational burden, an intratumoural T-cell response has been reported in a subset of MRTs, indicating that immune checkpoint inhibition may be consider

The Pleistocene-Holocene transition brought turbulent times to human societies confronted by rapid climatic fluctuations, shifts inbiogeographic zones and the flooding of continental shelves. While the disappearance of Doggerland’s inhabited landscapes underthe grey waters of the North Sea marks the culmination of these changes for European Archaeologists, our aim is this paper is todraw parallels

Objectives: The purpose of this study was to develop a procedure to investigate the occurrence, character and causes of magnetic resonance (MR) imaging incidents. Methods: A semi-structured questionnaire was developed containing details such as safety zones, examination complexity, staff MR knowledge, staff categories, and implementation of EU directive 2013/35. We focused on formally reported inc

This audio paper draws on analysis of a case study within the field of artistic research. In summer 2018, the project sent poet Gunnar D. Hansson, composer Anders Hultqvist and ecological sound artists Stefan Östersjö and Halla Steinunn Stefánsdóttir on a search for the sounds of the book Tapeshavet (Hansson, 2017). The work links to the author’s Activation Series, which employs the artistic metho

Climate warming is driving changes in species distributions and community composition. Many species have a so-called climatic debt, that is, shifts in range lag behind shifts in temperature isoclines. Inside protected areas (PAs), community changes in response to climate warming can be facilitated by greater colonization rates by warm-dwelling species, but also mitigated by lowering extirpation ra

The dynein motor protein transports proteins away from the cell membrane along the microtubule network. Recently, we found the microtubule network was important for regulating the membrane abundance of voltage-gated Kv7.4 potassium channels in vascular smooth muscle. Here, we aimed to investigate the influence of dynein on the microtubule-dependent internalization of the Kv7.4 channel. Patch-clamp

Purpose: Sinonasal malignancies (SNM) represent a rare and complex group of cancers that includes a wide range of histopathological subtypes. Data from population-based cohorts are scarce but warranted as a basis for randomized controlled treatment trials (RCTs). Our aim was to assess overall and histology subset-specific outcomes for SNM patients treated at a tertiary referral centre. Methods: A

BACKGROUND: Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this study were to map patterns, risk factors, and the possibility of curative treatment of recurrent colorectal cancer in a multimodal setting. METHODS: This was a coh

RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp, activator of the "stringent" response and regulator of cellular metabolism. The classical "long" RSHs Rel, RelA and SpoT with the ppGpp hydrolase, synthetase, TGS and ACT domain architecture

Polycyclic aromatic hydrocarbons (PAHs) are produced by anthropogenic activities, such as traffic and domestic heating. Due to their adverse effects to humans and natural habitats, the presence of PAHs in the environment needs to be monitored. Plants are known as natural accumulators of persistent organic pollutants (POPs) and can therefore be used for the monitoring of PAHs emitted into the envir

Introduction.Streptococcus dysgalactiae subspecies equisimilis (SDSE) is becoming increasingly recognized as an important human pathogen. Recurrent bacteremia with SDSE has been described previously.Aim. The aims of the study were to establish the genetic relatedness of SDSE isolates with emm-type stG643 that had caused recurrent bacteraemia in three patients and to search for signs of horizontal

Decomposition of litter is a key biochemical process that regulates the rate and magnitude of CO2 fluxes from biosphere to atmosphere and determines soil nutrient availability. Although several studies have shown that plant litter decomposition accelerated in their native compared to a foreign environment, that is, a home-field advantage (HFA) for litter degradation, to date HFA has only been cons

Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce cDC1 fate in mouse fibroblasts, but reprogramming of human somatic cells was lim

Cold region ecosystems store vast amounts of soil organic carbon (C), which upon warming and decomposition can affect the C balance and potentially change these ecosystems from C sinks to carbon dioxide (CO2) sources. We quantified the decadal year-round CO2 flux from an alpine steppe-ecosystem on the Tibetan Plateau using eddy covariance and automatic chamber approaches during a period of signifi

Social media facilitates the sharing of ideas, thoughts and information about older people and later life through online networks and communities in contemporary society. Social media content about older people has become important for understanding media representations of older people, but it has not been sufficiently studied. Recent studies suggest that older people are predominantly represente

Soil microorganisms regulate the decomposition of organic matter. However, microbial activities can also be rate-limited by the resource in lowest supply. Arctic ecosystems are being exposed to pronounced climate warming, with arctic greening, treeline advance and shrubification resulting in increased plant-derived carbon (C) inputs to soils, and faster rates of decomposition releasing mineral nut

Land biosphere processes are of central importance to the climate system. Specifically, ecosystems interact with the atmosphere through a variety of feedback loops that modulate energy, water, and CO2 fluxes between the land surface and the atmosphere across a wide range of temporal and spatial scales. Human land use and land cover modification add a further level of complexity to land-atmosphere