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IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions.

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Countercurrent distribution of lymphocytes from human peripheral blood in an aqueous two-phase system. : II. Separation into subsets of lymphocytes with distinctive functions

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Prevention and Management of Bleeding Episodes in Children with Hemophilia

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Induction of platelet thrombi by bacteria and antibodies.

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

The Comparative and Combined Effects of Nitric Oxide and Higher Alkanes in Sensitizing Methane Oxidation

The comparative and combined effects of nitric oxide (NO) and higher alkanes on methane oxidation were examined by experimentation and kinetic modeling. Experiments were conducted using fuel-lean, lower-alkanes mixtures with NO (0-400 ppm v/v) in an atmospheric flow reactor at residence time of 2 s over the temperature range of 820-950 K. NO was found to greatly promote methane conversion, and its

Experimental and numerical study of ground vortex interaction in an air-intake

The airflow field around air-intake related geometries has been investigated experimentally and numerically. The configuration of the experimental set-up is used to model a jet engine running near the ground. The experiments have been carried out using both PIV and LDA techniques in order to obtain the mean and fluctuating velocity field as well as the low speed frequencies related to the system o

Ledarskap i försvaret - en fenomenologisk undersökning av KB-elevers perspektiv före och efter en strapatsvecka

We have conducted a phenomenological study on students who will become officers (KB-elever) and our subject is leadership. Our first purpose was to determine their point of view in leadership and how the describe it on two occasions. One occasion before and one after a field-training course in survival techniques. We also wanted to see if the view on leadership was shared and if it had changed aft

Comparing Chemical Reaction Mechanisms for Jet Fuel in Turbulent Premixed Combustion Simulations

The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri

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Master’s Dissertation Structural Mechanics JOHAN HERLUF MATTSSON Report TV SM -5182 JO H A N H ERLU F M A TTSSO N EA R TH Q U A K E A N A LY SIS O F PIPE SU PPO R TS IN N U C LEA R PO W ER PLA N TS EARTHQUAKE ANALYSIS OF PIPE SUPPORTS IN NUCLEAR POWER PLANTS Detta är en tom sida! Copyright © 2012 by Structural Mechanics, LTH, Sweden. Printed by Media-Tryck LU, Lund, Sweden, November, 2012 (Pl). Fo

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5182.pdf - 2026-05-25

Leif Lönnblad

Professor Contact details Email: leif [dot] lonnblad [at] fysik [dot] lu [dot] se Phone: +46 46 222 77 80Organisation Particle and nuclear physics Visiting address: Sölvegatan 14A, Lund Room number: K233 Service point: 14 WebpageLeif Lönnblads profile in Lund University research portalResearchQCD Phenomenology and Monte Carlo Event Generators.TeachingTheoretical Particle Physics (FYTN18) and (Expl

https://www.particle-nuclear.lu.se/leif-lonnblad - 2026-05-26