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Lately, evidence for early-Holocene emerging sedentism has been suggested among foragers in Northern Europe. The core of this suggested sedentism lies in the increasing dependency on large-scale fishing and mass consumption of fish and a territorial behaviour associated with access to the best fishing locations. This territoriality might also be associated with increasing numbers of people settlin
Background: Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts. This initially provides essential mechanical support to the heart, but eventually compromises function. Osteopontin is associated with fibrosis; however, the underlying signaling m
BACKGROUND: Resection of the primary tumour is a prerequisite for cure in patients with colorectal cancer, but hepatic metastasectomy has been used increasingly with curative intent. This national registry study examined prognostic factors for radically treated primary tumours, including the subgroup of patients undergoing liver metastasectomy. METHODS: Patients who had radical resection of primar
Background: Newborn screening (NBS) for long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) deficiency does not discriminate between isolated LCHAD deficiency, isolated long-chain keto acyl-CoA (LCKAT) deficiency and general mitochondrial trifunctional protein (MTP) deficiency. Therefore, screening for LCHAD deficiency inevitably comprises screening for MTP deficiency, which is much less amenable
Background: Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. Objective: To determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic
Entomological radars employing the 'ZLC' (zenith-pointing linear-polarized narrow-angle conical scan) configuration detect individual insects flying overhead and can retrieve information about a target's trajectory (its direction and speed), the insect's body alignment and four parameters that characterize the target itself: its radar cross section, two shape parameters and its wingbeat frequency.
Angioedema in the mouth or upper airways is a feared adverse reaction to angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) treatment, which is used for hypertension, heart failure and diabetes complications. This candidate gene and genome-wide association study aimed to identify genetic variants predisposing to angioedema induced by these drugs. The discovery co
BACKGROUND: Tau aggregation in neurons and glial cells characterizes tauopathies as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Tau proteolysis has been proposed as a trigger for tau aggregation and tau fragments have been observed in brain and cerebrospinal fluid (CSF). Our group identified a major tau cleavage at amino acid (aa) 224 in CSF
Time to blood culture positivity (TTP) is an indirect measure of bacterial concentration in blood. A short TTP has been linked to the presence of infective endocarditis (IE) and to poor prognosis in Staphylococcus aureus bacteremia. We analyze factors influencing TTP in bacteremia with Enterococcus faecalis. This retrospective observational study of medical records included adults diagnosed with m
The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF). Using a bioinformatics approach, we found that CSPG4, MCAM, and AOC3 correlate with MYOCD, MRTF-A/MKL1, and SRF across human tissues. No other transcription factor correlat
Allozyme data were used to assess the genetic structure between 37 sympatric populations of the species-pair Silene vulgaris and S. uniflora ssp. petraea, and to infer levels of intra- and interspecific gene flow in the two species. Silene vulgaris is a geographically widespread weed of disturbed habitats whereas S. uniflora ssp. petraea is endemic to the Baltic islands of Öland and Gotland. On Öl
Dissemination of Bacillus anthracis from the respiratory mucosa is a critical step in the establishment of inhalational anthrax. Recent in vitro and in vivo studies indicated that this organism was able to penetrate the lung epithelium by directly entering into epithelial cells of the lung; however the molecular details of B. anthracis breaching the epithelium were lacking. Here, using a combinati
INTRODUCTION: Programmed death-ligand 1 (PD-L1) expression is used for treatment prediction in non-small cell lung cancer (NSCLC). While cytology may be the only available material in the routine clinical setting, testing in clinical trials has mainly been based on biopsies.METHODS: We included 2 retrospective cohorts of paired, concurrently sampled, cytological specimens and biopsies. Also, the l
‘Modern astronomy’ was introduced to Siam (present-day Thailand) when the Belgian Jesuit missionary-astronomer Father Antoine Thomas carried out astronomical observations in 1681 and 1682 in order to determine the latitude and longitude of Ayutthaya. Three years later a contingent of French Jesuit missionary astronomers observed a total lunar eclipse from Lop Buri, which marked the start of an int
Background and Aims: Little is known about small-bowel (SB) capsule endoscopy (CE) in patients with a history of gastric surgery. This study aims to evaluate the feasibility and diagnostic yield (DY) of orally ingested SB-CE in patients with surgically altered gastric anatomy. Methods: Twenty-four European centers retrospectively identified patients who had SB-CE after total or subtotal gastrectom
Soil cation exchange capacity (CEC) strongly influences the chemical, physical, and biological properties of soil. As the direct measurement of the CEC is difficult, costly, and time-consuming, the indirect estimation of CEC from chemical and physical parameters has been considered as an alternative method by researchers. Accordingly, in this study, a new hybrid model using a support vector machin
