Filtyp
Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities and is characterized by the onset of acute respiratory distress within 6 hours of a blood transfusion. There are no specific therapies available and the pathogenesis remains unclear. Pre-existing inflammation is a risk factor for TRALI and neutrophils (PMNs) are considered to be the major p
OBJECTIVE: Decision-making concerning the extent of the repair of acute type A aortic dissection (ATAAD) includes functional and anatomical assessment of the aortic valve. We hypothesized that bicuspid aortic valve (BAV) does not impact outcome after surgery for ATAAD. We therefore evaluated the outcome after ATAAD surgery in relation to the presence of BAV, acute aortic regurgitation (AR), and su
Lesions in the gene encoding steroid 21-hydroxylase result in congenital adrenal hyperplasia, with impaired secretion of cortisol and aldosterone from the adrenal cortex and overproduction of androgens. A limited number of mutations account for the majority of mutated alleles, but additional rare mutations are responsible for the symptoms in some patients. A total of 11 missense mutations has prev
Some lactic acid bacteria, especially Lactobacillus spp., possess adhesive properties enabling colonization of the human gastrointestinal tract. Two probiotic Lactobacillus plantarum strains, WCSF1 and 299v, display highly different mannose-specific adhesion, with L. plantarum 299v being superior to L. plantarum WCFS1 based on a yeast agglutination assay. A straightforward correlation between the
Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate these mutated ERs or altered transcriptional activation function, expression vectors containing wild-typ
Background: It has been established that patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have co-existing asthma. Objective: We aimed to test two hypotheses: (i) upper and lower airway inflammation in CRSwNP is uniform in agreement with the united airways concept; and (ii) bronchial inflammation exists in all CRSwNP patients irrespective of clinical asthma status. Methods: We
The calcium antagonistic properties of (+)‐T‐cadinol, some of its stereoisomers and related terpenes were investigated in both functional and radioligand binding studies, and the effects were compared with those of the dihydropyridine calcium antagonist (±)‐nimodipine. In the isolated rat aorta, the terpenes relaxed contractions induced by 60 mM K+ more potently than those induced by phenylephrine
Definitions and understandings of disease are to a large extent culturally dependent, even if there are also biological components to this. While many medieval religious orders nursed an interest for science and knowledge in general, their approach to medicine was complicated by the complex attitude towards illness and the tending of the body within Christendom. Archaeological artifacts from Ciste
We review the ecological and socio-economic impacts of the catastrophic dam failure in Mariana, Brazil. Tailing management practices by Samarco mining company ultimately caused a dam breach that abruptly discharged between 55 and 62 million m3 of tailings into the Doce River watershed. On November 5th, 2015, a tsunami of slurry engulfed the small district of Bento Rodrigues, loading the Doce River
The “bivalent domain,” a distinctive histone modification signature, is characterized by repressive trimethylation of histone H3 at lysine 27 (H3K27me3) and active trimethylation of histone H3 at lysine 4 (H3K4me3) marks. Maintenance and dynamic resolution of these histone marks play important roles in regulating differentiation processes i
Purpose: The purpose of the study is to compare the efficacy and safety profile of 2.0% dorzolamide (three times daily) and 0.5% timolol (twice daily) for up to 6 months in patients with glaucoma or ocular hypertension associated with pseudoexfoliation. The additive effects of dorzolamide and timolol in patients requiring add-on therapy also was evaluated. Methods: This was a double-masked, random
Background.Task-shifting mental health into general medical care requires more than brief provider training. Generalists need long-term support to master new skills and changes to work context are required to sustain change in the face of competing priorities. We examined program and context factors promoting sustainability of a mental health task-shifting training for hospital-based HIV providers
This thesis investigates the climate impact of a newly constructed residential complex in Oceanhamnen, Helsingborg, through an extended life cycle assessment (LCA) covering both building and non-building elements such as road infrastructure, inner courtyards, external installations, that area often overlooked in conventional assessments. The aim is to develop a replicable method to quantify the gl
In modern recruitment, organizations tend to face a persistent paradox: they must align candidates with existing cultural values while simultaneously promoting workforce diversity. This thesis investigates how HR professionals navigate the inherent tension between organizational fit and diversity within recruitment processes across multinational public and private organizations in Europe and South
The increasing global demand for sustainable energy has sparked interest in combining renewable technologies to leverage their synergies. This thesis presents a pre-feasibility study of a combined offshore wind and wave energy farm located off the coast of Galicia, Spain. In collaboration with Wavepiston, a Danish developer of wave energy converters (WECs), the study evaluates the integration of t
With the expansion of social media, aesthetics have emerged as a tool to inspire as well as curate identity and lifestyle online. Previous research has found that the mobilisation of aesthetics has been essential for gaining followers and curating a softer outward image to new audiences. This study aims to better understand how the far-right uses nature aesthetics to gain followers and visualise t
Shrub range expansion, also known as shrubification, across arctic and subarctic ecosystems is expected to increase with climate change, with implications for vegetation structure, biodiversity, and soil carbon dynamics. Previous research has found a shrubification-induced decrease in organic matter stocks from tundra to forest in the organic horizon, prompting further investigation into whether t
