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Organic pollutants in aquatic environments pose a threat to ecosystems and human health, a challenge that requires urgent resolution. This urgent threat highlights the need for the development of efficient technologies for pollutant detection and degradation in environmental protection. This study presents the successful fabrication of a composite nanomaterial consisting of Ag nanoparticle-decorat

Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st

Residents of the Sahel depend on livestock, but harsh environmental conditions during the dry season limit rangeland forage, which is the main source of livestock feed. Al-though operational tools exist for assessing and monitoring forage quantity during the dry season, assessments of forage quality are lacking. We addressed this gap by developing satellite-based monitoring of forage quality acros

A clear understanding of the mechanisms governing the growth of nanowires is crucial to achieving control over their structures and properties. Here, we employ molecular dynamics (MD) simulations to investigate several important phenomena in Au-catalyzed Si nanowires (SiNWs) grown via the vapor–liquid–solid method. MD simulation serves as a complementary tool for uncovering the mechanisms of nanow

In the aftermath of the Covid-19 pandemic, the accelerated shift to remote and hybrid work modes has left many office buildings vacant. Meanwhile, many cities struggle with providing housing. Adaptive reuse (AR) is the process of giving an existing building a new life, typically through an extensive renovation and refurbishment. Residential adaptative reuse specifically refers to adapting for hous

Crystallization-induced stress within confined spaces of porous materials presents significant challenges across various disciplines, including conservation science, geomorphology, geotechnical engineering, and concrete durability. Despite its significance, understanding how localized, transient, and anisotropic stress is generated in pores due to salt crystallization, along with its mechanisms of

A peptide corresponding to a 13-residue segment of the human protein semenogelin I has been shown to generate a hydrogel consisting of amyloid-like fibrils. The relative chemical diversity (compared to synthetic de novo sequences) with 11 distinct amino acids makes this peptide (P0) an ideal candidate for investigating the role of individual residues in gelation. Herein, the N-terminal residues ha

With timely allocated movement phases, mobile organisms can match their space-use with the seasonality of the environment and thereby optimise their resource utilisation over time. Long-distance avian migrants are known to move with the seasonal dynamics on an annual basis, but how individuals respond to seasonality within their tropical non-breeding range has been less studied. Here we analyse th

MORC2 (Microorchidia CW type Zinc Finger protein 2) is a GHKL (gyrase, heat shock protein 90, histidine kinase, MutL) ATPase involved in chromatin remodeling and is highly conserved in eukaryotes. Mutations in the ATPase domain of MORC2 are known to cause neurodevelopmental disorders. MORC2 is recruited by the HUSH complex to target long, intronless transcription units such as LINE-1 retrotranspos

Background: Estrogen receptor alpha (ERα) is a protein that belongs to the nuclear receptor family. It is regulating the expression of genes involved in cell cycle progression, proliferation, and apoptosis. Approximately 75% of breast cancers express ERα, making it an important target for treatment. Researchers have identified various isoforms of ERα, with the most well-characterized one being a 6

För att lösa dagens bostadsbrist utan att det sker på bekostnad av värdefull mark, satsar en övervägande del av de svenska kommunerna på förtätning. Den främsta fördelen med att bygga tätt är att det optimerar förutsättningarna för variation i serviceutbudet och leder till ett effektivare utnyttjande av infrastrukturen. Dock påstår många att nya bostäder i samband med förtätning skulle ge värdesänIn order to solve housing shortage while preserving valuable land, a majority of the Swedish municipalities are implementing densification as a planning strategy. Denser development provides better support for a variety of services and optimizes public transportation. Despite the several benefits, infill development is commonly claimed to lower nearby housing prices. Studies on whether new residen

Single-domain antibody fragments, also called nanobodies, that target the spike glycoprotein of SARS-CoV-2 can potently neutralize the virus and prevent infection. In our first aim, we investigated whether their neutralization potency can be further increased by multimerization and generated multivalent constructs of a recently identified SARS-CoV-2 neutralizing nanobody, Ty1. We applied a novel m

I mitt examensarbete har jag arbetat med ett projekt i kommunen där jag bor, nämligen i Svedala. Här har det länge funnits en önskan om en attraktiv simhall från invånarnas sida, men ännu finns det ingen i kommunen. Därför tar jag chansen - på eget initiativ av mig som fristående arkitektstudent - att i mitt examensarbete gestalta ett hållbart badhus åt Svedalas invånare. Arbetet är upplagt på sIn my degree project, I have worked on a project with a sustainable swimming hall in the municipality of Svedala, where I live. Still, there is no swimming hall in the whole municipality, altough there has been an increased desire to create an attractive one that considers the needs of the residents. Therefore, I took the initiative - as an independent architecture student - to propose and design

Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases re-quires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro dia

Understanding the emergence and development of coastal adaptations is a central theme in the archaeology of Maritime Northeast Asia. The capacity to harvest, store and share aquatic resources offered a novel economic strategy that could support greater sedentism and new forms of social life. In turn, growing reliance on the exploitation of rich coastal resources wouldhave generated powerful incent

The Pleistocene-Holocene transition brought turbulent times to human societies confronted by rapid climatic fluctuations, shifts inbiogeographic zones and the flooding of continental shelves. While the disappearance of Doggerland’s inhabited landscapes underthe grey waters of the North Sea marks the culmination of these changes for European Archaeologists, our aim is this paper is todraw parallels

Objectives: The purpose of this study was to develop a procedure to investigate the occurrence, character and causes of magnetic resonance (MR) imaging incidents. Methods: A semi-structured questionnaire was developed containing details such as safety zones, examination complexity, staff MR knowledge, staff categories, and implementation of EU directive 2013/35. We focused on formally reported inc