Filtyp
Introduction: Giant-cell tumor of bone (GCTB) is a locally aggressive histologically benign neoplasm with a less common malignant counterpart. Longitudinal data sources on GCTB are sparse, limited to single institution case series or surgical outcomes studies. The Swedish Cancer Registry is one of the few national population-based databases recording GCTB, representing a unique source to study GCT
Change is sweeping through the world of museums, technologically, financially, and ideologically, impacting on the sociocultural evolution of their roles and status. We seek to contribute to ongoing reflections by offering a conceptual framework that links museums with democratic theory, to citizenship and its practices – a domain that is also in notable transition. We connect concretely with the
Background The pattern of cancer in long-term survivors from childhood cancer has not been investigated comprehensively. Methods We obtained a cohort of 47 697 children and adolescents aged 0-19 years with cancer as defined by the country-wide cancer registries of Denmark, Finland, Iceland, Norway, and Sweden during 1943-2005. Cohort members were followed through age 79 years for subsequent primar
Popular Abstract in Swedish Avhandlingens delstudier omfattar kvantitativa och kvalitativa data rörande en grupp tonåringar och unga vuxna med dyslexi. Såväl kognitiva som psykosociala faktorer undersöktes. Gruppen bestod av 75 ungdomar mellan 14 och 25 år som fick diagnosen dyslexi någon gång mellan 1994 och 1999. Datainsamlingen genomfördes 2003 - 2004. Intervallet mellan diagnostillfället och uThe studies in this doctoral thesis report aspects of cognitive and socio emotional development in a group of teenagers and young adults with dyslexia. The 75 subjects, between 14 and 25 years of age, had been diagnosed in the latter half of the 1990s, and the collection of quantitative and qualitative data was performed in 2003-04. Study I investigated the stability of intelligence. Earlier rese
Background: Activated phosphoinositide 3-kinase δ syndrome (APDS) 2 (p110δ-activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI]-R1), a recently described primary immunodeficiency, results from autosomal dominant mutations in PIK3R1, the gene encoding the regulatory subunit (p85α, p55α, and p50α) of class IA phosphoinositide 3-kinases. Objectives: We sought
Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial dysfunction and reduced insulin secretion are also observed in β-cells of humans with the most common human genetic disorder, Down syndrome (DS, Trisomy
BACKGROUND: There is a worldwide increase in the incidence of cutaneous malignant melanoma (CMM) among whites. In Sweden, a five-fold increase has been recorded since 1960, although the increase in mortality rate is substantially lower. Tumor thickness is recognized as the most important histologic prognostic factor for primary melanoma. In a previous study, the authors did not find any significan
Peroxisomes and mitochondria were purified from potato tubers (Solanum tuberosum L. cv. Bintje) by differential centrifugation followed by separation on a continuous Percoll gradient containing 0.3 M sucrose in the lower half and 0.3 M mannitol in the upper half. The peroxisomes band at the bottom and the mitochondria in the middle of this type of gradient. Mitochondrial contamination of the perox
Conventional wastewater treatment plants are designed for treating manmade wastewater (e.g., from households and industries) and to protect the environment (e.g., receiving water bodies) and humans from adverse effects.The objective of this work was to investigate the feasibility of treating municipal wastewater without a biological treatment step by applying different separation processes, such a
Earth observing systems are now routinely used to infer leaf area index (LAI) given its significance in spatial aggregation of land surface fluxes. Whether LAI is an appropriate scaling parameter for daytime growing season energy budget, surface conductance (Gs), water- and light-use efficiency and surface–atmosphere coupling of European boreal coniferous forests was explored using eddy-covariance
Popular Abstract in Swedish Under de senaste decennierna har utbredningen och förekomsten i av många arter av fåglar, växter och insekter knutna till jordbrukslandskap på olika håll i Europa minskat på grund av jordbrukets rationalisering och intensifiering. För att motverka dessa negativa trender måste man ha kännedom om den relativa betydelsen av lokala och regionala ekologiska processer för popDuring the last decades, the distribution and abundance of many European species of birds, plants and insects in agricultural landscapes have declined due to agricultural intensification. To be able to mitigate these declines, it is essential to know the relative importance on local and regional ecological processes on population persistence and patterns of species richness. I have studied the ef
Popular Abstract in Swedish Cancer i tjocktarm och ändtarm (colorektal cancer) är en av de vanligaste cancerformerna i västvärlden. Årligen insjuknar drygt 5 000 människor i Sverige i denna sjukdom, och ungefär hälften av dessa dör till följd av sin cancer. De som avlider i colorektal cancer har i de allra flesta fall spridning av tumören till andra organ (metastasering). Levern är den vanligaste
Popular Abstract in Swedish I vår omgivning finns många gasformiga ämnen, vars egenskaper är sådana att de kan mätas med optiska metoder. Härvid kan man utnyttja det unika spektroskopiska fingeravtryck ämnena har. Det vill säga, att varje ämne absorberar ljus av olika färg (våglängd) på ett unikt sätt. Likaså har vissa ämnen sådana egenskaper, att då de belyses med en viss våglängd sänder de ut enMulti-spectral lidar (light detection and ranging) techniques have been developed and employed in various environmental studies, ranging from concentration mapping of volcanic emissions to fluorescence imaging of historical monuments. In both absorption measurements of gaseous species and fluorescence imaging of stones, multiple wavelength excitation and multiple wavelength detection have been app
Benchmarking har blivit en allt vanligare metod för lärosätens kvalitetsarbete. Lunds universitet har deltagit i benchmarkingprojekt organiserade av European Centre for Strategic Management of Universities (ESMU) sedan 2000. Sedan några år tillbaka medverkar Lunds universitet återigen i ett antal internationella projekt rörande benchmarking av e-lärande, nämligen EADTU:s E-xcellence+, ESMU:s eLear
Popular Abstract in Swedish Avhandlingens titel: Självskadebeteende bland ungdomar: resultat från tvärsnitts- och longitudinella studier i svenska skolor. Självskadebeteende bland ungdomar (exempelvis när någon skär, bränner eller slår sig själva, eller avsiktligt åsamkar sig direkta skador på något annat sätt) har uppmärksammats som ett växande problem under de senaste årtiondena. Kunskap om omfaSelf-injury in adolescents (e.g. when individuals cut, burn, hit or otherwise deliberately cause themselves direct injury), has gained recognition as a potentially important mental health problem during the past decade. Relatively little has been known about the scope and characteristics of this behavior in Swedish adolescents. This thesis consists of three studies that in different ways explore
Popular Abstract in SwedishEtt väl etablerat fynd inom personbedömningsforskning är att vi människor bedömer varandra på ett mer nyanserat sätt än enbart en endimensionell skala (bra-dålig). Istället använder vi oss av två grundläggande dimensioner för personbedömningar. Den första dimensionen (värme) ger oss svaret på andra människors avsikter (t.ex. vänligt eller fientligt inställda till oss). DIt is well established that we do not judge other people on a one-dimensional scale (i.e., good - bad), but rather based on two fundamental dimensions. The first dimension is warmth, which essentially answers the questions of what the other person’s intentions are (e.g., friendly or malicious). The second dimension is competence, which in contrast answers the question regarding the person’s capabi
Sedan 2010 stadgar skollagen att ”Utbildningen ska vila på vetenskaplig grund och beprövad erfarenhet.”. Skollagen ger i sig ingen ledning till hur dessa begrepp ska tolkas. Uttrycket står på en egen rad i kap 1 §5, som annars handlar om demokrati, mänskliga rättigheter, förhål-landet till religion, med mera. Avsaknaden av precisering av begreppet är problematisk då det är första gången som begrep
Objectives Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK. Methods Two cohorts of rubber workers employed for at least 1 year were analysed. Standardised incidence
AIMS: Exosome-mediated microRNA transfer is a recently discovered mode of cell-to-cell communication, in which microRNAs act as paracrine molecules, exerting their regulatory effects in recipient cells. T cells and endothelial cells are two main players in the mechanism of acute cellular cardiac rejection. The aim of this study was to investigate the role of exosomal microRNAs in the crosstalk bet
Disease prevalence in wildlife is governed by epidemiological parameters (infection and recovery rates) and response to infection, both of which vary within and among individual hosts. Studies quantifying these individual-scale parameters and documenting their source of variation in wild hosts are fundamental for predicting disease dynamics. Such studies do not exist for the influenza A virus (IAV
