Filtyp
Greenhouses and nursery-gardens is an important business in Sweden, covering a land area of 3,0 million square meters in 2011. The downside of this otherwise blooming business is however the use of so called PPPs, plant protection products, which is connected to it. Historically the use of PPPs has been widespread and the handling has been conducted in an off-hand way. During the post-war time the
Popular summary Energy generation from renewable sources is one of the main issues to be solved for the 21st century. One of the most advanced technologies currently available is wind energy, which has a large potential onshore and offshore. However, in many cases wind energy is restricted to large wind parks with wind power plants sometimes exceeding heights of 100 m. The construction of large wi
Popular science summary: Do bacteria survive in humans by eating the defense molecules during the course of infection? Enterococcus faecalis (E. faecalis) is a pathogen that can be found in the human gut which causes a wide range of infections including urinary tract infections, cardiovascular infections and bacteremia (presence of bacterial cells in blood stream). These bacteria can also be fou
As the world is changing rapidly in many ways, competition is getting increasingly fierce amongst manufacturing firms. As such, it has become more and more important for companies to properly understand the needs of their customers in order to provide enough value to be sufficiently competitive. Providing delivery and installation services which might’ve been viewed as necessary evils before have
Titel: Placering av europeiskt distributionscentrum för att minska LUL-transporter för företag inom industrin för lagrade alkoholhaltiga drycker Författare: Josefin Berntson, Cecilia Flink Handledare: Sebastian Pashaei, Avdelningen för industriell ekonomi och logistik, Lunds Tekniska Högskola, Lunds universitet. Problembeskrivning: Den ökade efterfrågan av distribution, som ett resultat av den Title: Allocation of a European Distribution Center to Minimize LUL Shipments for Companies within the Aged Alcoholic Beverage Industry Authors: Josefin Berntson, Cecilia Flink Supervisor: Sebastian Pashaei, Department of Industrial Management and Logistics, Faculty of Engineering, Lund University Problem description: The increased demand for distribution as a result of the globalization has in
Children affected by the multisystem genetic disorder Hutchinson-Gilford Progeria Syndrome look prematurely aged, suffer from elderly-related conditions and die during adolescence due to cardiovascular complications. The cause of the disease is single point gain-of-function mutations in the LMNA gene, which encodes the lamin A and lamin C proteins, major components of the nuclear lamina. These mut
As CO2 builds up in the atmosphere causing global climate change (IPCC, 2022) trees have become an international symbol of combatting this, and for good reason. Trees take up CO2 which as a result combats these changes, and when these trees are cut down fewer individuals remain to take up the CO2 that we humans emit (Chapin et al., 2011). This means that clear-cut areas don’t act as the carbon sin
Glucose-evoked insulin secretion exhibits two phases: The first phase represents exocytosis of insulin granules situated at the plasma membrane, whereas the second phase reflects insulin release from granules continuously recruited to the plasma membrane. This thesis investigates different aspects of phasic insulin secretion, with the specific aims to elucidate the possible contribution of insulin
The Proton Exchange Membrane (PEM) fuel cell has been investigated for a long time, and is regarded as a new energy source for various applications, such as portable, stationary and automotive ones. However, due to the shortage of the infrastructure in the society, the high cost, the difficulty of the water/thermal management, etc., practical systems have not reached the general public, yet. Of t
Wind power developments in cold and icing conditions pose new challenges to the wind power industry. Icing of wind turbines cause safety hazards, production losses and increased loads. This means that there is a need to develop a technique to quantify the icing climatology and corresponding eects on wind turbines to enable large scale wind power developments in the windy, sparesly populated areas
Currently, policy makers put high attention in supplying global energy demand by focusing on 2°C policy; global temperature anomaly based on the global mean temperature of pre-industrial era (13.7°C). How to keep the 2°C policy at global scope is the main question in climate framework. It is widely believed that primary energy resources (mainly coal, oil and natural gas) with focus on shale gas re
My allotment got me thinking about what wonders nature does to man and our current stressful world we live in. How does the work environment look today and how can we arrange the office to find inspiration and an appetite for knowledge? This led me into the project ”The Working Scene”, the study of the working environments and how we can approve on the office. We are all in some way part of a glo
Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. Sialic acid plays a crucial role forpathogenic bacteria, since it is used as a source of car
The incorporation of water isotopologues into the hydrology of general circulation models (GCMs) facilitates the comparison between modeled and measured proxy data in paleoclimate archives. However, the variability and drivers of measured and modeled water isotopologues, as well as the diversity of their representation in different models, are not well constrained. Improving our understanding of t
Aims/hypothesis: Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previous genome-wide association studies (GWAS) on DKD and by integrating the results with renal transcriptomics datasets. Methods: We performed GWAS meta-analyses us
Environmental pollution is a significant concern for scientists, practitioners, authorities and the society. Among the various pollutants, chlorinated solvents pose a considerable risk to our groundwater resources. These hazardous chemicals, often used in industrial processes, can contaminate soil and water, posing a threat to both human health and ecosystems. Detecting and tracking the spread of
Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri
Land remediation is an important part of restoration measures after a radioactive fallout containing long-lived fission products such as 137Cs. In this multidisciplinary study, we focused on three main issues related to remediation of contaminated urban areas. First, we assessed how much decontamination contributes to reducing resident radiation exposure and how much this reduction depends on the
Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,
Background The leucine-rich repeat kinase 2 gene (LRRK2) harbours highly penetrant mutations that are linked to familial parkinsonism. However, the extent of its polymorphic variability in relation to risk of Parkinson's disease (PD) has not been assessed systematically. We therefore assessed the frequency of LRRK2 exonic variants in individuals with and without PD, to investigate the role of the
