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Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa

The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t

The joint actions of animals in partnerships or social groups evolve under both natural selection from the wider environment and social selection imposed by other members of the pair or group. We used experimental evolution to investigate how jointly expressed actions evolve upon exposure to a new environmental challenge. Our work focused on the evolution of carrion nest preparation by pairs of bu

Klimatförändringarna påverkar vår värld och det behövs ett mer hållbart samhälle. Flygindustrin är i behov av förändring, men flygmotorer är mycket komplexa och tar tid att utveckla. Termoakustiska instabiliteter har kraften att förstöra en motor, men också att minska miljöpåverkan. Samtidigt möjliggör ökad beräkningskraft i moderna datorkluster att detaljerade simuleringar kan utföras för att stuClimate change is affecting our world and a more sustainable society is needed. The aviation industry is in need of change but aero-engines are very complex and take time to develop. Thermoacoustic instabilities have the power to destroy an engine, but also to reduce the environmental impact. At the same time, increasing computational power allows detailed simulations to be executed in order to st

Populism invokes the authority of the people against an élite. Often that entails a rejection of the authority of experts and their criteria for a valid discourse. This tension surfaces in conflicts around conspiracy theories and here is suggested that this tension is seen as a conflict between two interpretations of reality, of particular phenomena or history. The question is what role the philos

Cancer-associated alterations in cell surface and secreted glycoproteins have been catalogued for many years but many of the studies of alterations in mucin carbohydrate have relied on histochemical or immunohistochemical methods, with little direct chemical analysis. In this study, we analyzed the O-glycosylation pattern of MUC2 glycoprotein isolated from colorectal carcinomas, transitional mucos

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/goteborgs-stad/dokument/facklig-foretradare/sveriges-skolledares-dokument/skolledningsnytt-nr11-2024.pdf - 2026-05-26