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Modulations of glypican-1 heparan sulfate structure by inhibition of endogenous polyamine synthesis. Mapping of spermine-binding sites and heparanase, heparin lyase, and nitric oxide/nitrite cleavage sites

Cell surface heparan sulfate proteoglycans facilitate uptake of growth-promoting polyamines (Belting, M., Persson, S., and Fransson, L.-A. (1999) Biochem. J. 338, 317-323; Belting, M., Borsig, L., Fuster, M. M., Brown, J. R., Persson, L., Fransson, L.-A., and Esko, J. D. (2001) Proc. Natl. Acad. Sci. U. S. A., in press). Here, we have analyzed the effect of polyamine deprivation on the structure a

Specific Derivatization of the Active Site Tyrosine in dUTPase Perturbs Ligand Binding to the Active Site

Selective modification of one (of three) tyrosine residue per enzyme monomer leads to inactivation of dUTPase of the retrovirus equine infectious anemia virus (EIAV). The substrate dUMP and the cofactor Mg2+protects against inactivation and modification, in agreement with the study onE. colidUTPase (Vertessyet al.(1994)Biochim. Biophys. Acta1205, 146-150). Amino acid analyses of nitrated dUTPases

Posterleipzig haeussler

Using spatially explicit process- based modelling to quantify wild bee dynamics and their pollination services Johanna Häusslera,b,c*, Ullrika Sahlinc, Charlotte Baeyc, Henrik G. Smithc,d and Yann Cloughc a German Centre for Integrative Biodiversity Research (iDiv) Halle- Jena-Leipzig, Deutscher Platz 5e, 04103 Leipzig, Germany b Institute of Ecology, Friedrich Schiller University Jena, Domburger-

https://www.cec.lu.se/sites/cec.lu.se/files/posterleipzig_haeussler.pdf - 2026-05-29

EXJOBB Ramona

Estimating biomass and phenology in African Rangelands using Earth Observation Background: INES (Lars Eklundh and Jonas Ardö) recently got a contract for a project (RAMONA, staring in December 2021) with the European Space Agency (ESA). This project aims to develop and apply methodology to assess grazing resources in African Rangelands using (mainly) data from the Sentinels (Sentinel 1,2, and 3 in

https://www.nateko.lu.se/sites/nateko.lu.se/files/2021-11/EXJOBB_Ramona.pdf - 2026-05-29

No title

CAMBODIA NATIONAL LAW AND POLICY REPORT CONSULTATION DRAFT 2020 Displacement in the Context of Disasters and Climate Change Funded by This report was prepared by Victor Bernard (RWI) and Matthew Scott (RWI) 2020 TABLE OF CONTENTS 1 INTRODUCTION 1 1.1. A human rights-based approach 1 2 Displacement in Numbers 3 2.1. Number of disasters and people affected in the last ten years (2009–2018) 3 3 Recom

https://rwi.lu.se/wp-content/uploads/2024/03/Consultation-Draft_Cambodia.pdf - 2026-05-28

Laurianne Allezard

Postdoc Contact details Email: laurianne [dot] allezard [at] jur [dot] lu [dot] se Phone: +46 46 222 11 32Organisation Department of Law Room number: 433 Service point: 56 WebpageLaurianne Allezards profile in Lund University research portal Publications Displaying of publications. Sorted by year, then title. Filter by type AllBookBook chapterEditor for a journalJournal article Filter The Anatomy

https://www.law.lu.se/laurianne-allezard - 2026-05-28

No title

Madame Beurre e ta fille Sofie (drömmer/tänker) un voyage en Italie. Madame Beurre fais du soleil et Sofie parle avec l'italienne garçons. Elles ont des drapeaus, vert, blanc et rouge. Ta voiture, une Citroën, c'est vert et petit. Sofie a une valise blanche et madame Beurre a une valise vert. Elles travailles sur un rue avec des fleures rouges. Dans l'hôtel c'est un grand homme. Il guard les clés.

https://projekt.ht.lu.se/fileadmin/user_upload/project/cefle/textes/le_sous-corpus_longitudinal/bror/Texte_3.txt - 2026-05-28

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding

The role of K396 in the enzymatic catalysis and the antigenicity of the 65 kDa isoform of glutamate decarboxylase (GAD65) was analyzed using the K396R GAD65 mutant. GAD65 is a major autoantigen in Type 1 diabetes and autoantibodies directed to GAD65 are widely used markers for this disease. We found that (1) recombinant human GAD65 is fully enzymatically active; (2) the K396R mutation abolished GA

Mapping of the factor Xa-binding site on factor Va by site-directed mutagenesis.

Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be important for factor Xa binding. To further define which residues are important for factor Xa binding, we prepared fifteen recombinant factor V varia

Geological characterisation of geophysical lineaments as part of the expanded site descriptive model around the planned repository site for high-level nuclear waste, Forsmark, Sweden

Svenska Kärnbränslehanteringen (SKB) startade ett projekt under 2020 i närheten av Forsmark i Sverige med målet att utöka deformationszonsmodellen till att inkludera hela dräneringsområdet runt om det planerade slutförvaret för använt kärnbränsle. Detta arbete bygger på en lineamentmodell som var skapad för SKB. Denna modell använder sig av magnetiska data tillsammans med höjddata samt data insamlThe Swedish Nuclear Fuel and Waste Management Co. (SKB) started a project in 2020 near Forsmark, Sweden with the aim to expand the deformation zone model to encompass the entire catchment area around the planned repository for spent nuclear fuel. This thesis builds upon a lineament model that was constructed for SKB which utilizes airborne magnetic data supported by airborne Very Low Frequency (VL

Survival in cancer of unknown primary site: population-based analysis by site and histology

Cancer of unknown primary (CUP) is diagnosed at a metastatic stage, conferring an unfavorable prognosis. The natural history of the disease is poorly understood, which complicates diagnosis, treatment and follow-up. Population-based survival data are lacking regarding location and histology of metastases. From the Swedish Cancer Registry, 18 911 CUP patients were identified between years 1987 and

Multiscale Modeling of the Active Site of [Fe] Hydrogenase: The H-2 Binding Site in Open and Closed Protein Conformations

A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT+ and th

LUCSUS seminars

Principally on Thursdays, 11.00-12.00 CET, at LUCSUS Join our research seminar with LUCSUS researchers and invited guests presenting their latest research. Autumn programme 2025The programme is updated continuously. January 22Too hot, too cold: dwelling in discomfort as a question of thermal justice11-12 in MaathaiSpeaker: Alice Guilbert, doctoral researcher and assistant at the Institute of Envir

https://www.lucsus.lu.se/seminars - 2026-05-27

Countercurrent Distribution of Lymphocytes from Human Peripheral Blood in an Aqueous Two-Phase System : I. Separation into Subsets of Lymphocytes Bearing Distinctive Markers’

Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o