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The galectins are a family of galactose-binding proteins playing key roles in inflammatory processes and cancer. However, they are structurally very closely related, and discovery of highly selective inhibitors is challenging. In this work, we report the design of novel inhibitors binding to a subsite unique to galectin-3, which confers both high selectivity and affinity towards galectin-3. Olefin
The nature of today’s business demands that Business Analytics (BA) extends to an operational level to better support employees in their decision-making. This is noticeable from the constant requests for new reports and changes in old ones at different employee levels. As a result, BA specialists or other power-users in functional departments are “bombarded” by these requests, and it becomes more
Background: Hepatopancreatoduodenectomy (HPD) is an aggressive operation for treatment of advanced bile duct and gallbladder cancer associated with high perioperative morbidity and mortality, and uncertain oncological benefit in terms of survival. Few reports on HPD from Western centers exist. The purpose of this study was to evaluate safety and efficacy for HPD in European centers. Method: Member
With data from two comparable corpora of spoken British English, the London-Lund Corpus and the new London-Lund Corpus 2, this study tracks the development of the reactive what-x construction half a century back in time. The study has two goals: (i) to describe the uses of the construction over time and (ii) to establish the motivations and mechanisms related to its development in spoken dialogue.
The phage Mu DNA transposition system provides a versatile species non-specific tool for molecular biology, genetic engineering and genome modification applications. Mu transposition is catalyzed by MuA transposase, with DNA cleavage and integration reactions ultimately attaching the transposon DNA to target DNA. To improve the activity of the Mu DNA transposition machinery, we mutagenized MuA pro
The General Data Protection Regulation (GDPR) came into force in May 2018. The aspiration of providing for a high level of protection to individuals’ personal data risked placing considerable constraints on scientific research, which was contrary to various research traditions across the EU. Therefore, along with the set of carefully outlined data subjects’ rights, the GDPR provides for a two-leve
This study investigated the relationship between perceived indoor temperature in winter and frailty among community-dwelling older people. This cross-sectional study included 342 people 65 years and older in Japan. Participants answered questions about demographics, frailty, housing, and perceived indoor temperature in winter. Participants were grouped based on perceived indoor temperature (Cold o
We examine how building and appliance technologies relate to their use by occupants through practices at home and at work. The aim is to analyse how practices are influenced by buildings and other technologies and by social requirements and to add to ongoing research on how to contribute to a transition to more sustainable everyday practices. Interview, quantitative and observational material are
Directed relation graph with error propagation (DRGEP) method combined with extensive validation for 0D, 1D and 2D CFD modeling supported by sensitivity and Rate-Of-Production (ROP) analyses are implemented for comparative study of detailed and reduced kinetic mechanisms for CH 4
The aim of the present article is to put culture on the agenda when discussing and working with IC reporting and IC management. Differences between Spain and Sweden in the Meritum work are discussed in relation to the interest and experience of IC among firms; and the way the firms develop IC management and IC reporting. We propose that culture might affect the assumptions of knowledge as well as
IntroductionThe World Health Organization (WHO) has concluded that physical inactivity and overweight/obesity are the world's fourth and fifth leading risk factors for non-communicable diseases, respectively. This article investigates the potential for active commuting by bicycle in Scania county, southern Sweden, and its possible impact on public health. Physical inactivity is a growing problem o
Cognitive behavioral therapy (CBT) designed to target Generalized Anxiety Disorder (GAD) in youth was examined in a pilot feasibility trial. Participants (aged 10-18 years) were randomized to either 10 weeks of individual CBT (n = 20) or supported wait-list (n = 20). Diagnostic status (primary outcome) was assessed blindly at post-treatment for both groups, and at a 3-month follow-up for treated p
The shell condenser is one of the key components of underwater vehicles. To study its thermal performance and to design a more efficient structure, a computational model is generated to simulate condensation inside straight and helical channels. The model combines empirical correlations and a MATLAB-based iterative algorithm. The vapor quality is used as a sign of the degree of condensation. Three
Aging buildings will sooner or later be in need of renovation, which opens opportunities to reduce energy use. Even if economically feasible energy measures or technologies exist, they are not always implemented, leading to an energy efficiency gap. This dissertation deals with how energy measures are handled and why they are enabled or disabled during the planning and design of renovations. Durin
In this study, steady-state laminar natural convection of Cu and TiO 2 nanofluids inside different enclosures is numerically investigated. Natural convection is concerned due to a temperature difference between the hot and cold
The antimicrobial effects of Laponite nanoparticles with or without loading of the antimicrobial peptide LL-37 was investigated along with their membrane interactions. The study combines data from ellipsometry, circular dichroism, fluorescence spectroscopy, particle size/ζ potential measurements, and confocal microscopy. As a result of the net negative charge of Laponite, loading of net positively
We present a case of a patient in a severe pulmonary mucormycosis during the neutropenic phase of treatment for acute myeloblastic leukaemia (AML), type M2. He had two major risk factors for setting infection; leukaemia and diabetes mellitus. Although he received antimicrobial and antifungal therapy with Amphotericin B in time, it was unable to eradicate infection. We performed a pneumectomy, whic
