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BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of trans

Avdelningen för hematologi och klinisk immunologi

Vi studerar blod- och immunsystemet och dess sjukdomar. Ett särskilt fokusområde är hur medfödd genetisk variation påverkar hur blod- och immunceller, och hur sådan variation kan utnyttjas kliniskt. Vilka gener och genmutationer styr t ex risken för blodcancer? Kan vi utnyttja dem för att förebygga och behandla? Vilka styr vår blodgruppsuppsättning? Kan vi utnyttja dem för säkrare transfusion? EttWe study the blood and immune system and its diseases. A particular focus area is how congenital genetic variation affects blood and immune cells, and how such variation can be utilized clinically. Which genes and gene mutations control, for example, the risk of blood cancer? Can we use them to prevent and treat? Who controls our blood group set? Can we use them for safer transfusion? Another impo

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Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly