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To improve population health, it is important to create environments that support activity, participation and health. One crucial aspect concerns the degree to which the built environment is accessible for all people including those with reduced functional capacity. The overarching objective of this thesis was to explore and further develop methodology for accessibility assessments based on the no
Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. Antiproliferative spermine-binding DS fragments (tetra- to decasaccharides), and aff
Combining the strengths of an advanced mathematical model of human physiology and a thermal manikin is a new paradigm for simulating thermal behaviour of humans. However, the forerunners of such adaptive manikins showed some substantial limitations. This project aimed to determine the opportunities and constraints of the existing thermal manikins when dynamically controlled by a mathematical model
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Kadmium är en giftig metall vilken finns i mat som vi rekommenderas äta mycket av, exempelvis sädesprodukter, grönsaker och skaldjur. Våra matjordar är kontaminerade med kadmium och föroreningen kommer att kvarstå under mycket lång tid framöver. Kadmium skadar framförallt njurarna och skelettet och kan antagligen även orsaAbstract: Cadmium (Cd) is ubiquitous in the environment. Human exposure in non-smokers occurs mainly via intake of healthy food like vegetables, cereals, and shellfish. Adverse health effects on kidney and bone at low-level environmental Cd exposure are well-documented in adults. There is considerable inter-individual variation in both metabolism (toxicokinetics) and toxicity (toxicodynamics) of C
Abstract in UndeterminedAgricultural systems continuously evolve and are forced to change as a result of a range of global and local driving forces. Agricultural technologies and agricultural, environmental and rural development policies are increasingly designed to contribute to the sustainability of agricultural systems and to enhance contributions of agricultural systems to sustainable developm
Isomeric states in nuclei with Z = 62-67 and A = 142-152 produced in the fragmentation of the relativistic (1 GeV/nucleon) Pb-208 beam were investigated. Isomeric ratios were determined for 10 isomeric states. Significant differences between theoretical and experimental values were observed.
Disasters such as the storms that affected Sweden in 2005 and 2007 showed that citizens initially conducted a large part of the disaster response, such as clearing roads, giving psychosocial support to affected neighbours and repairing power lines in collaboration with power companies. As a result of these storms, an Emergent Citizen Group (ECG) was established in a village which continued to work
Background: Gaucher disease (GD) is the most common inherited lysosomal storage disorder in humans, caused by mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GBA1). GD is clinically heterogeneous and although the type of GBA1 mutation plays a role in determining the type of GD, it does not explain the clinical variability seen among patients. Cumulative evidence from recent
As the title largely illustrates, this study seeks to investigate, from a diplomatic-history and geostrategic perspective, the key developments in Anglo-Iranian relations during what may best be dubbed their “formative years,” ranging from 1907 to 1953. Having thus provided a glimpse into pre-twentieth-century Persian–British relations, it moves to analyze the division of Persia into two spheres o
This study evaluates whether the use of an acceleration advisor leads to fuel savings, to determine the change in traffic-related emissions and to analyse changes in driving patterns on various routes. The acceleration advisor provides advice to drivers through resistance in the accelerator pedal when they try to accelerate rapidly. In a test carried out in Southern Sweden, the acceleration adviso
This paper treats estimation of the Wigner-Ville spectrum (WVS) of Gaussian continuous-time stochastic processes using Cohen's class of time-frequency representations of random signals. We study the minimum mean square error estimation kernel for locally stationary processes in Silverman's sense, and two modifications where we first allow chirp multiplication and then allow nonnegative linear comb
Phenotypic plasticity is the ability of a genotype to modify its phenotypic characteristics in response to different environments. Theory predicts that adaptive plasticity should primarily evolve in organisms that experience heterogeneous environments. An organism's dispersal rate is a key component in these models, because the degree of dispersal partly determines the extent of environmental hete
Abstract Background: Mass-weighted aerodynamic particle-size distribution (APSD) is a key attribute for pharmaceutical products developed to deliver drugs to or through the lungs. In development and quality control, APSD is primarily determined using multistage cascade impactors. For impactor techniques, particle reentrainment is critical because it may lead to an overestimation of the respirable
An analytical strategy to determine metals in environmental samples contaminated with both organophosphate pesticides and metals is presented. In the first step, parathion and arsenate were determined separately. Inhibition of the enzyme butyrylcholinesterase was quantified employing an enzyme thermistor and also with a CCD camera. Subsequently, parathion mixed with arsenate was measured. A molecu
