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Popular Abstract in Swedish Tänk dig ett system som kan bestämma hur olika typer av luftpartiklar skadar oss när dom hamnar i våra lungor. Ett system som dessutom kan skapa luftpartiklar för dessa studier vid behov och med väl uppmätta egenskaper. Denna avhandling handlar om just ett sådant system och experiment som är viktiga för att förstå om och hur det fungerar. Systemet kallas i denna avhandlExposure to nano-sized and nanostructured aerosol particles with tailored properties are likely to increase in society. Occupational exposure to various kinds of nanostructured aerosol particles such as soot and metal aggregates already exists. To understand the adverse human health effects of these particles, there is a need for systems that can Generate a stable output of aerosol particles, Char

Background: In 2015, six indicators were proposed to evaluate global progress towards access to safe, affordable and timely surgical and anaesthesia care. Although some have been adopted as core global health indicators, none has been evaluated systematically. The aims of this study were to assess the availability, comparability and utility of the indicators, and to present available data and upda

Objectives: To examine the associations between socioeconomic/occupational factors and liver cancer at various anatomic sites (including primary liver, gallbladder and other cancers). Methods: We carried out a follow-up study on the economically active Swedish population, based on the Swedish Family-Cancer Database. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calcu

Magnesium and potassium concentrations were determined in plasma, erythrocytes and urine collected during 24 h, and in percutaneous muscle biopsies obtained in 30 healthy subjects. Magnesium was also analyzed in mononuclear cells. Men, compared to women, showed a higher urinary excretion of magnesium (p less than 0.05). The magnesium contents in mononuclear cells correlated significantly with the

Purpose: The purpose of this study was to explore the relationship between oxidative stress, antioxidant defense, mitochondrial structure, and biomechanical tissue support in the isolated porcine retina.Methods: Full-thickness retinal sheets were isolated from adult porcine eyes. Retinas were cultured for 2 or 48 h using (1) a previously established low-support explant protocol with photoreceptors

In this article we argue the need for more socio-legal scrutiny in a digitally mediated and data-driven development. We focus and briefly outline socio-legally relevant aspects of the “sharing” economy, that poses a number of conceptual issues on how we understand and regulate innovative platform based ventures. This also arguably underscores a number of issues relating to the role of consumer and

During pregnancy and involution, an extensive remodelling of the human cervical connective tissue occurs. This cervical ripening is one of the most pronounced physiological remodelling processes known in human connective tissue. To investigate how the remodelling is accomplished, the levels of mRNA for collagen I and III, versican and three small proteoglycans, biglycan, decorin and fibromodulin,

Introduction: The importance of mobile health has increased during recent years but few studies have described the use of apps among persons with neurological disabilities. Aim: The aim of this paper was to describe how persons ageing with a neurological disability experience barriers and facilitators in relation to using apps in everyday life. Method: A qualitative approach was used. 16 persons w

Current models for the growth of Fennoscandia, including the eastern part of the Sveconorwegian Province, are largely based on U-Pb data and do not discriminate between juvenile and reworked crust. Here we present new combined U-Pb and Hf isotopic data, from the Eastern Segment and the Idefjorden terrane of the Sveconorwegian Province, and suggest a revised model of crustal growth. Most of the cry

This study investigates the effects of Age of Onset of Acquisition (AOA) and the quality and quantity of input on the longitudinal development of gender in the acquisition of French by simultaneous (2L1) and successive bilinguals (cL2). Three exponents of French gender are studied: the discovery of the abstract GENDER feature, gender assignment and gender concord. The findings show that the amount

Protein S is a vitamin K dependent plasma protein and a cofactor to activated protein C, a serine protease that regulates blood coagulation. The haploid genome contains two protein S genes (alpha and beta) with the protein S alpha-gene corresponding to the cloned cDNA. We have now isolated and mapped overlapping genomic clones that cover an area of 50 kilobases of the protein S alpha-gene which co

This thesis analyses the operations of the principle of proportionality when the Court of Justice reviews national measures that restrict the fundamental freedoms laid down in the EU Treaties. That judicial review often entails balancing of rights, and this study is a quest for coherence in the adjudication of different, and at times perplexing legal norms, of various national and international or

Recent studies have indicated that serum and plasma cystatin C are better markers for glomerular filtration rate (GFR) than serum creatinine, ubiquitously used for this purpose. To fully exploit the value of serum and plasma cystatin C as GFR markers, reliable age and sex-correlated reference intervals are required. The present study comprised cystatin C determinations in plasma and sera from 259

Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic for chronic migraine. Curiously, inhibition of neurokinin receptor 1 (NK1R) failed to alleviate acute migraine attacks in clinical trials, and th