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The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of solid tumor metastasis. Preclinical research relies on xenograft mouse models, but these models preclude the human-specific functional interactions of stem cells with their bone marrow microenvir
The mechanical response of a woven eight-harness satin graphite/polyimide composite has been investigated by performing ± 45° tensile and Iosipescu shear tests at room temperature. Nonlinear finite element simulations of the tests have been conducted to determine internal stress distributions in the ±45° tensile and Iosipescu fabric specimens as a function of load. In the experimental part of this
Interferon gamma (IFNγ) is central to the inflammatory immune response, such as that entrained by BCG immunotherapy for bladder cancer. However, immune-mediated tumour cell killing is subject to modulation by immunoinhibitory “checkpoint” receptors such as PD-L1. We investigated the effects of IFNγ on barrier-forming in vitro-differentiated normal human urothelium using mRNA-sequencing, and showed
Background: The application of Pulsed Electric Field (PEF) to food may result in reversible or irreversible electroporation of cell membranes, depending on whether cell homeostasis is restored after resealing. Restoration of homeostasis upon reversible electroporation implies the recovery of the pre-pulse transmembrane potential and the restoration of cell metabolic functions. Enhanced membrane pe
Background: Malnutrition, sedentary lifestyle, cognitive dysfunction and poor psychological well-being are often reported in patients on haemodialysis (HD). Aims: We aimed to explore needs, barriers and facilitators—as perceived by patients, their carers, and healthcare professionals (HCPs) for increasing the adherence to the diet, to physical activity and cognition and psychological well-being. M
Background: Lumbar puncture (LP) is a common invasive procedure, most frequently performed to diagnose infection. Physicians perform LP in newborn infants with the help of an assistant using a strict aseptic technique; it is important to monitor the infant during all the steps of the procedure. Without adequate analgesia, LP can cause considerable pain and discomfort. As newborns have increased se
The exchange-correlation potential formalism previously introduced and applied to the one-dimensional Hubbard model has been extended to spin systems and applied to the case of the one-dimensional antiferromagnetic spin-12 Heisenberg model. Within the spin exchange-correlation potential formulation, a sum rule for spin systems is derived. The exchange-correlation potential for the Heisenberg model
We present the first systematic comparison of the charged-particle pseudorapidity densities for three widely different collision systems, pp, p–Pb, and Pb–Pb, at the top energy of the Large Hadron Collider (sNN=5.02TeV) measured over a wide pseudorapidity range (−3.5
Yangia sp. ND199 is a moderately halophilic bacterium isolated from mangrove samples in Northern Vietnam, which was earlier reported to grow on several sugars and glycerol to accumulate poly(hydroxyalkanoates) (PHA). In this study, the potential of the bacterium for co-production of exopolysaccharides (EPS) and PHA was investigated. Genome sequence analysis of the closely related Yangia sp. CCB-M3
Missions are being discussed widely within the European Union and beyond as a tool to steer policy, innovation, and research. Similar to other missions – to the moon, to cure cancer, and to eradicate smallpox – the missions-oriented approach seeks to set bold and radical goals to tackle our pressing environmental and social challenges. In this episode, we discuss the missions-oriented approach for
Despite the fact that the laser-cooling method is a well-established technique to obtain ultracold neutral atoms and atomic cations, it has rarely if ever been applied to atomic anions due to the lack of suitable electric-dipole transitions. Efforts of more than a decade have until recently only resulted in La- as a promising anion candidate for laser cooling, but our previous work [Tang et al., P
Microscopy analysis of tumour samples is commonly performed on fixed, thinly sectioned and protein-labelled tissues. However, these examinations do not reveal the intricate three-dimensional structures of tumours, nor enable the detection of aberrant transcripts. Here, we report a method, which we name DIIFCO (for diagnosing in situ immunofluorescence-labelled cleared oncosamples), for the multimo
Detta är en debattartikel. Det är skribenten som står för åsikterna som förs fram i texten, inte Aftonbladet.För det första behöver konsumtionen av animalisk föda minska. Detta minskar utsläppen av den kraftfulla växthusgasen metan som idisslare producerar, skriver Henrik Smith, professor i zooekologi.
The Damages Directive has been celebrated as a milestone for the private enforcement of EU competition law. The Directive harmonises national procedural laws and aims to facilitate full compensation for damages occurred as a result of competition law violations. At the same time, US and EU businesses more frequently use contractual clauses that might present obstacles in obtaining compensation. Re
In this paper we provide a counterpoint to conventional views on integrative reviews in knowledge development, as exemplified by Elsbach and Van Knippenberg (2020). First, we critique their proposed integrative review by identifying and problematizing several key assumptions underlying it, particularly their idea that the integrative review can simply build on existing studies and lead the way to
Objective: To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design: We included 17,153 men and 18,682 women from a population-based cohort, aged 35–70 years at baseline (1995–1997). Incident hand OA were obtained from diagnostic codes in the Norwegian National Patient Register (1995
