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Understanding the impact of the geometry and material composition of electrodes on the survival and behavior of retinal cells is of importance for both fundamental cell studies and neuromodulation applications. We investigate how dissociated retinal cells from C57BL/6J mice interact with electrodes made of vertically-aligned carbon nanotubes grown on silicon dioxide substrates. We compare electrod
Research during the latest years has indicated a significant connection between climate and solar activity. Specifically, a relationship between Northern Hemisphere air temperature and sunspot cycle length (SCL) has been shown. By using monthly SCL and land air temperature from 1753-1990 (238 years) we show that this relationship also holds for a single observation point in south of Sweden. Using
The principle of self-determination plays a crucial role in contemporary clinical ethics. Somewhat simplified, it states that it is ultimately the patient who should decide whether or not to accept suggested treatment or care. Although the principle is much discussed in the academic literature, one important aspect has been neglected, namely the fact that real-world decision making is temporally e
Popular Abstract in Swedish Avhandlingen berör det så kallade "struktur och rörelse"-problemet som är centralt inom datorseendefältet. Målet är att givet tvådimensionella bilder av ett föremål, kunna återskapa dess tredimensionella form och koordinater i rummet, dvs strukturen, samtidigt med kamerans position relativt objektet i varje bild, dvs rörelsen. Inom robotiken kallas tekniken för "simultaThis thesis presents contributions to structure-and-motion estimation, a central topic in the field of geometric computer vision. In particular, the problem of view planning is considered, and continuous and discrete optimization-based algorithms are given for how to plan the path of a sensor to its destination, while balancing the competing goals of path length and reconstruction accuracy. The sa
This invention comprises, on one hand, a method of detecting and quantifying components separated by capillary electrophoresis or other technique using thin capillaries in the separation, and on the other hand, an apparatus for performing this detection. The method comprises irradiating the whole or large parts of the capillary at short time intervals and detecting the fluorescence originating fro
Objectives: To determine the impact of the COVID-19 pandemic on the incidence rates of infection and islet autoimmunity in children at risk for type 1 diabetes. Methods: 1050 children aged 4 to 7 months with an elevated genetic risk for type 1 diabetes were recruited from Germany, Poland, Sweden, Belgium and the UK. Reported infection episodes and islet autoantibody development were monitored unti
This chapter analyses the implications of findings in epigenetics for the ascription of moral responsibility for children. It contrasts shared understandings of procreative responsibility and discusses its extension to include all (individual or collective) actors who influence a child’s gene expression. It also problematizes the focus on biology in this process, using the example of epigenetics a
We have developed a sampling method for beamline simulations for the proposed NNBAR experiment at the European Spallation Source. The method is based on probability density evaluation and duct source biasing and enables the simulations of the entire NNBAR beamline with high statistics while also preserving correlations of the neutron tracks. Future efforts will focus on employing these methods for
Sustainability and resilience are two related but distinct theories of coupled environmental and social systems. Both have been heavily debated and contested over recent decades, and both are highly relevant for understanding, managing, and living with and within riverine landscapes. In this chapter, I summarise key concepts of sustainability and social–ecological resilience theories and discuss t
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment and are imperative for disease progression as well as recurrence during treatment-free remission (TFR). Here, we have generated high-resolut
Malnutrition is the most common comorbidity during the continuum of hematopoietic stem cell transplant (HSCT) and negatively impacts clinical outcomes, response to therapy, quality of life, and costs. The intensive conditioning regimen administered before transplant causes inflammatory damages to the gastrointestinal system, which themselves contribute to trigger graft versus host disease (GvHD) i
In medical research and within the field of Biology, it is important to find effective tools for probing and manipulating cells, as well as tools for detecting biomolecules. These tools should be sensitive, with high specitivity, and, if aimed at interacting with cells, they should be minimally invasive. In this thesis, I investigated the potential of various nanotools for these purposes. Specific
OBJECTIVE: The objective of the study was to estimate the risk for postoperative adhesions and intestinal obstruction after cesarean delivery and to estimate whether the rate remains stable over time. STUDY DESIGN: Women who had the aforementioned diagnoses in the Swedish Hospital Discharge Registry were linked to the Swedish Medical Birth Registry. Women with diagnoses increasing the risk for adh
Assessment of robustness of structural systems very often involves assessment of the structural response after local damage. In this paper an attempt is made to describe the state of art in this field with focus on methods which can be used in engineering practice. Advanced non-linear and dynamic computer tools are available today which can deal with most of the above mentioned phenomena but they
