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C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury

Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress triggered by blood transfusions and is the leading cause of transfusion-related mortality. TRALI has primarily been attributed to passive infusion of HLA and/or human neutrophil antigen antibodies present in transfused blood products, and predisposing factors such as inflammation are known to be important for TRALI

The Revised Sunspot Record in Comparison to Cosmogenic Radionuclide-Based Solar Activity Reconstructions

Recent revisions in the sunspot records illustrate the challenges related to obtaining a 400-year-long observational record of past solar-activity changes. Cosmogenic radionuclides offer the possibility of obtaining an alternative and completely independent record of solar variability. Here, we illustrate that these records offer great potential for quantitative solar-activity reconstructions far

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

BACKGROUND: The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Intérieur Consortium, a total of 1000 healthy individuals of western European ancestry, with a 1:1 sex ratio and evenly stratified across five decades of life (age 20-69), w

Open Data Collaborations - A snapshot of an emerging practice

Data defined software is becoming more and more prevalent, especially with the advent of machine learning and artificial intelligence. With data defined systems come both challenges - to continue to collect and maintain quality data - and opportunities - open innovation by sharing with others. We propose Open Data Collaboration (ODC) to describe pecuniary and non-pecuniary sharing of open data, si

Decentralized Massive MIMO Systems: Is There Anything to be Discussed?

Algorithms for Massive MIMO uplink detection are typically based on a centralized approach, by which baseband data from all antenna modules need to be routed to a central node for further processing. In the case of Massive MIMO, where hundreds or thousands of antennas are expected in the base-station, such architecture requires high interconnection bandwidth between antennas and the central node.

Girth Properties of Time-Varying SC-LDPC Convolutional Codes

Time-varying spatially-coupled low-density parity-check convolutional codes (SC-LDPC-CCs) exhibit excellent features, but their representation requires a very large number of parameters. On the other hand, the description of time-invariant SC-LDPC-CCs is very convenient and their error rate performance, though usually worse, is often satisfactory. In this paper we investigate the girth properties

Massive MIMO with a Generalized Channel Model : Fundamental Aspects

Massive multiple-input multiple-output (MIMO) is becoming a mature technology, and has been approved for standardization in the 5G space. Although there are many papers on the theoretical analysis of massive MIMO, the majority of relevant work assumes the simplified, yet overly idealistic, Kronecker-type model for spatial correlation. Motivated by the deficiencies of the Kronecker model, we invoke

Synchronizing ice-core and U/Th timescales in the Last Glacial Maximum using Hulu Cave 14C and new 10Be measurements from Greenland and Antarctica

Between 15 and 27kyrb2k (thousands of years before 2000CE) during the last glacial, Greenland experienced a prolonged cold stadial phase, interrupted by two short-lived warm interstadials. Greenland ice-core calcium data show two periods, preceding the interstadials, of anomalously high atmospheric dust loading, the origin of which is not well understood. At approximately the same time as the Gree

Predicting post-operative functional ability from pre-operative measures in ACL-injured individuals

Purpose: This study aimed to quantify the relationship between objective and subjective measures of functional ability and determine if measures in the deficient (ACLd) state were correlated to, and capable of predicting a patient's objective and subjective measures in the reconstructed (ACLr) state. Methods: Twenty ACL-injured participants completed hop and side cut movements prior to and 10 mont

Atmospheric radiocarbon levels were highly variable during the last deglaciation

Radiocarbon dating provides a key chronological framework for studying past environmental changes. Raw radiocarbon ages measured in samples must be converted to calendar ages using an appropriate calibration curve. Tree-ring datasets provide the gold-standard for developing a precise curve of atmospheric radiocarbon levels over long-time scales. Here, we reconstruct atmospheric radiocarbon levels

Solar variability over the Holocene period : disentangling geomagnetic and solar influences on a new continuous 10Be record from Little Dome C, Antarctica

Reliable information on solar activity over the Holocene period is important to predict the Sun in the future and to understand the mechanism behind the Sun-climate linkage. Presently, there are discrepancies in the proxy data of solar activity due to reasons that are not yet understood. This leads to major uncertainties in Holocene solar reconstructions. This PhD project aims to improve the Holoc

Multiproxy Reconstructions of Integral Energy Spectra for Extreme Solar Particle Events of 7176 BCE, 660 BCE, 775 CE, and 994 CE

Extreme solar particle events (ESPEs) are rare and the most potent known processes of solar eruptive activity. During ESPEs, a vast amount of cosmogenic isotopes (CIs) 10Be, 36Cl, and 14C can be produced in the Earth's atmosphere and deposited in natural stratified archives. Accordingly, CI measurements in these archives allow us to evaluate particle fluxes during ESPEs. In this work, we present a

The ST22 chronology for the Skytrain Ice Rise ice core - Part 2 : An age model to the last interglacial and disturbed deep stratigraphy

We present an age model for the 651g€¯m deep ice core from Skytrain Ice Rise, situated inland of the Ronne Ice Shelf, Antarctica. The top 2000 years have previously been dated using age markers interpolated through annual layer counting. Below this, we align the Skytrain core to the AICC2012 age model using tie points in the ice and air phase, and we apply the Paleochrono program to obtain the bes

Development of the Intcal Database

The IntCal family of radiocarbon (14C) calibration curves is based on research spanning more than three decades. The IntCal group have collated the 14C and calendar age data (mostly derived from primary publications with other types of data and meta-data) and, since 2010, made them available for other sorts of analysis through an open-access database. This has ensured transparency in terms of the

Extreme Solar Events : Setting up a Paradigm

The Sun is magnetically active and often produces eruptive events on different energetic and temporal scales. Until recently, the upper limit of such events was unknown and believed to be roughly represented by direct instrumental observations. However, two types of extreme events were discovered recently: extreme solar energetic particle events on the multi-millennial time scale and super-flares

Extreme solar particle storms and links to solar activity inferred from cosmogenic radionuclides in ice cores

During solar storms, large amounts of solar energetic particles (SEP) are accelerated into the interplanetary medium and sometimes hit Earth. These events, known as SEP events, can have harmful impacts on our modern society by affecting spacecrafts and potentially astronauts in space. The first directly observed solar storm was the Carrington event in 1859 which is linked to disruptions of the tel

Tendency of soil erosion dynamics by coupling radioisotopes and RUSLE model on the Southeastern Tibetan Plateau in response to climate warming and human activity

Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros

Driftwood in the Eemian interglacial lacustrine unit from the Faroe Islands and its possible source areas : palaeobotanical and ichnological analysis

The coastal cliffs in Klaksvík (Borðoyar Bay) are the only known locality with Eemian sediments in the Faroe Islands. Previous studies carried out there focused on the sedimentology, tephra chemistry, paleoecology including aquatic environment, or the age of the deposits. In the lacustrine, clayey to silty gyttja we collected scattered wood fragments, identified as Larix sp., Pinus sp., Taxus sp.