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The objective of the present study is the investigation of possibilities for boosting peptide antiinflammatory effects by tryptophan end-tagging, including identification of underlying mechanisms for this. In doing so, effects of tryptophan end-tagging of KYE21 (KYEITTIHNLFRKLTHRLFRR), a peptide derived from heparin co-factor II, on membrane and lipopolysaccharide (LPS) interactions were investiga
A new foundation solution using a cellular raft with an active stabilisation system is proposed in this work. A comparative study of the new foundation and a traditional raft is performed. This study focuses on comparing the load capacity of the mentioned foundation solutions. The results illustrate that a cellular raft with an active stabilisation system gives a substantial enhancement of the loa
Mitophagy is a conserved cellular process that is important for autophagic removal of damaged mitochondria to maintain a healthy mitochondrial population. Mitophagy also appears to occur in plants and has roles in development, stress response, senescence, and programmed cell death. However, many of the genes that control mitophagy in yeast and animal cells are absent from plants, and no plant prot
Aim: DBS might be an appropriate microsampling technique for therapeutic drug monitoring of caffeine in infants. Nevertheless, its application presents several issues that still limit its use. This paper describes a validated DBS-LC-MS/MS method for caffeine. Results: The results of the method validation showed an hematocrit dependence. In the analysis of 96 paired plasma and DBS clinical samples,
According to the Swedish higher ordinance of education the development of autonomy of PhD students is of high importance. Graduates should be able to formulate new ideas and to independently assess and evaluate scientific results. Therefore it is interesting to investigate how the relationship between student and supervisor impacts the development of autonomy. In this work, we have evaluated the i
The UNESCO Post-2015 Development Agenda proposes equitable quality education and lifelong learning for all as its overarching goals for education. A holistic quality approach is espoused to encourage lifelong learning and thereby build inclusive, sustainable, and prosperous societies. Their quality goals are particularly ambitious given that the practical recommendations for inclusive education ne
In 1977 WHO published in the Bulletin a Memorandum on Methods for the Detection of Haemophilia Carriers. This was produced following a WHO/WFH (World Federation of Haemophilia) Meeting of Investigators in Geneva in November 1976, and has served as a valuable reference article on the genetics of haemophilia. The analyses discussed were based on phenotypic assessment, which, at that time, was the on
This chapter explores the ultrasonic additive manufacturing (UAM) advanced solid-state metal additive/subtractive manufacturing process that combines ultrasonic welding and computer numerical control milling to fabricate solid metal components, layer-by-layer, from metal foils. The chapter will discuss the three key abilities of UAM: complicated geometries, dissimilar material bonding, and object
The impedance bandwidth of a small antenna is a critical design parameter. In the present paper, we present stored energies which can be used as a tool to predict the largest possible bandwidth for antenna designs within a given region. These predictions are given in terms of the best possible Q-factor that can be attained within the region. The here presented energies are valid for structures tha
Described is a method for preparing a purified liquid containing carbohydrates. The method comprises the steps of: hydrolysing starch to a dextrose equivalent (DE) of 10 or above, thus obtaining a liquid of carbohydrates; removing a heavy weight sludge fraction from the light weight liquid of carbohydrates using centrifugation; filtering the remaining liquid of carbohydrates, the filter being capa
We establish Lieb–Thirring power bounds on discrete eigenvalues of Jacobi operators for Schatten class perturbations under very general assumptions. Our results apply, in particular, to perturbations of reflectionless Jacobi operators with finite gap and Cantor-type essential spectrum.
Air quality data assimilation aims to find a best estimate of the control parameters (see theory chapter) for those processes of the atmosphere which govern the chemical evolution of biologically relevant height levels, typically located in the the lowermost atmosphere. As in data assimilation (see theory chapters), we have to resort to numerical models to complement usually sparse observation net
Fluctuation relations are powerful equalities that hold far from equilibrium. However, the standard approach to include measurement and feedback schemes may become inapplicable in certain situations, including continuous measurements, precise measurements of continuous variables, and feedback induced irreversibility. Here we overcome these shortcomings by providing a recipe for producing detailed
This paper presents analysis of a scheme for iterated identification and control design. The approach is based on least squares identification in closed loop and pole placement design. It has previously been shown that the criteria for control and identification are the same provided that the data filters are chosen properly. The iterated scheme may be viewed as a recursion in model parameters. Ea
Population-level familial risks are not available for amyotrophic lateral sclerosis (ALS), and a few studies have analyzed familial association of ALS with other diseases. We used the Swedish Multigeneration Register to identify family members and link them to the Hospital Discharge Register to calculate standardized incidence ratios (SIRs) for familial association in ALS and 33 autoimmune disease
Invasive extravillous cytotrophoblast of the human placenta expresses galectins-1, -3, and -8 in vivo and in vitro. This study aimed to investigate the potential role of galectin-3 in cell migration and invasion, using recombinant human galectin-3 (rhgalectin-3), small molecule galectin inhibitor I 47 , and galect
Geoportals have been widely implemented by national spatial data infrastructures (NSDI) to provide users with the ability to search for geospatial resources over the Internet. This paper proposes an approach that can improve the functionalities of the conventional geoportals by adding recommendation capabilities to the execution mechanisms of geoportals. The geoportals with recommendation capabili
