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Background Lifestyle exposures play a major role in the development of disease, yet people vary in their susceptibility. A critical step towards precision medicine is identifying individuals who are resilient or sensitive to the environment, and, assess whether the allocation to these predicted groups are more or less likely to develop cardiometabolic disease.Methods We have used repeated data fro
Health impact assessments (HIA) have largely focused on mortality; this report, therefore, examines and evaluates which morbidity impacts are appropriate to include in HIAs. The task was assigned by Swedish Environmental Protection Agency (EPA), and the original report (written in Swedish) was performed by Anna Oudin (AO), Erin Flanagan (EF), and Ebba Malmqvist (EM). The original report also inclu
Limonene and linalool are among the most common fragrance terpenes used in everyday products. They are pre-haptens, forming hydroperoxides (Lim-OOHs, Lin-OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim-OOHs and Lin-OOHs by asking whether hydrop
Purpose: Delayed perineal wound healing is a common complication after abdominoperineal resection (APR) in rectal cancer. The primary aim of this study was to evaluate the number of patients with delayed wound healing after APR. Secondary aims were to identify risk factors, and describe treatment. Methods: Prospectively collected data from the Swedish Colorectal Cancer Registry (SCRCR) was used fo
Background: Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. This has been ascribed to reduced inhibition of CCK release from colon. In an earlier study CCK in all but one woman who was colectomised, induced release of oxytocin, a peptide present throughout the gastrointestinal (GI) tract. The aim of th
A dispersion relation for the combined effect of scattering and absorption of electromagnetic waves is presented for a large class of linear and passive material models. By invoking the optical theorem, the result states that the extinction cross section integrated over all frequencies is equal to the static limit of the extinction volume. The present paper focuses on an attempt to experimentally
A transmitter consisting of a voltage controlled oscillator (VCO) and power amplifier (PA) for the 400 MHz Medical Implanted Communication System band (MICS) was built in a standard 0.35-μm CMOS process. A push pull architecture was used for both the VCO and the PA. Two off-chip inductors were needed. The design was optimized for 400 μW output power at 3 V supply, which resulted in an efficiency o
Purpose - The purpose of this paper is to further build up the knowledge about reasons for small and mid-sized enterprises (SMEs) to adopt open source enterprise resource planning (ERP) systems. Design/methodology/approach - The paper presents and analyses findings in articles about proprietary ERPs and open source ERPs. In addition, a limited investigation of the distribution channel SourceForge
Background and purpose Although the incidence of hip fracture during the past 50 years has increased, a break in this trend has been reported in the last decade. Whether this change is attributable to changes in bone mineral density (BMD) or whether it varies between urban and rural regions is unknown. Methods We evaluated changes in annual hip fracture incidence in women aged >/= 50 years in one
Aims: To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults with pulmonary arterial hypertension (PAH). Methods and results: We followed the European Society of Cardiology (ESC) methodology for the development of QIs. This included (i) the identification of key domains of care for the management of PAH, (ii) the proposal of candidate QIs following sy
The purpose of this study was to evaluate the stability of complex markers implanted into lung tumors throughout a course of stereotactic body radiotherapy (SBRT). Fifteen patients referred for lung SBRT were prospectively included. Radio-opaque markers were implanted percutaneously, guided by computed tomography (CT). Deep inspiration breath-hold CT scans (BHCT) were acquired at planning and on t
Communication between cells located in different parts of an organism is often mediated by membrane-enveloped nanoparticles, such as extracellular vesicles (EVs). EV binding and cell uptake mechanisms depend on the heterogeneous composition of the EV membrane. From a colloidal perspective, the EV membrane interacts with other biological interfaces via both specific and non-specific interactions, w
Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included a
Background: Some groups of migrants have increased vulnerability to Sexually Transmitted Infections (STI) and Human Immunodeficiency Virus (HIV) transmission partly due to a lower uptake of disease preventive activities targeting the general population in receiving country. Limited access to economic and social resources and poor language skills may exacerbate exposure to sexual risks and utilizat
We present a-posteriori analysis of higher order finite element approximations (hp-FEM) for quadratic Fredholm-valued operator functions. Residual estimates for approximations of the algebraic eigenspaces are derived and we reduce the analysis of the estimator to the analysis of an associated boundary value problem. For the reasons of robustness we also consider approximations of the associated in
With the risk of climate breakdown, pressure is increasing for all sectors of the economy to break with fossil fuel dependence and reduce greenhouse gas emissions. In this context, the chemical industry requires more focused attention as it uses more fossil-fuel based energy than any other industry and the production of chemicals is associated with very large emissions. Beyond the climate crisis,
