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Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies

Monoclonal antibodies targeting CD20 are central in the treatment of B-cell lymphomas. In diffuse large B-cell lymphoma (DLBCL), inactivating mutations of the histone acetyltransferases CREB-binding protein (CBP) and EP300 are common. Moreover, knockdown of CBP in DLBCL has been shown to result in aberrant transcriptional silencing. Expression of CD20 is sensitive to epigenetic manipulation, and h

Analyzing political formation through historical isiXhosa text analysis: Using frequency analysis to examine emerging African Nationalism in South Africa

This paper showcases new research avenues made possible by applying computational methods to historical isiXhosa text. I outline a method for isiXhosa computational text analysis which adapts word frequency analysis to be applied to isiXhosa texts focusing on root words. The paper showcases the value of the approach in a study of emerging political identities in early African nationalism, examinin

Self tuning cylinder pressure based heat release computation

The paper describes a novel method for self tuning cylinder pressure based heat release computation that is suitable for online usage in e.g. combustion phasing control applications. The method estimates the polytropic exponents and cylinder pressure offsets immediately preceding and succeeding the combustion event respectively using a fast nonlinear least squares method. The polytropic exponent a

Aerosol characterization in real life and a methodology for human exposure studies in controlled chamber settings

Popular Abstract in Swedish Ta ett djupt andetag och tänk på vad du nu har i lungorna! Jo, det är luft, förstås, syre kväve och sådant. Men det är också något annat. I varje kubikcentimeter du andas in finns tusentals partiklar, alla för små för att kunna ses med blotta ögat. Om dessa partiklar handlar denna avhandling. Vi kallar luftburna partiklar för aerosoler, ett begrepp som innefattar allt Airborne particles are everywhere around us, and have always been. Particles generated by human activities has increased drastically since industrialization, and several epidemiological studies have shown that inhaled particles can cause adverse health effects. The concern about health effects have during the last decade shifted towards fine and ultrafine particles, not least due to the emerging f

Cracking the Sugar Code by Mass Spectrometry : An Invited Perspective in Honor of Dr. Catherine E. Costello, Recipient of the 2017 ASMS Distinguished Contribution Award

The structural study of glycans and glycoconjugates is essential to assign their roles in homeostasis, health, and disease. Once dominated by nuclear magnetic resonance spectroscopy, mass spectrometric methods have become the preferred toolbox for the determination of glycan structures at high sensitivity. The patterns of such structures in different cellular states now allow us to interpret the s

Lifestyle and cancer : effect of widowhood and divorce

Limited data are available on the possible changes in cancer risk brought about by widowhood and divorce, an increasing segment of the population. We calculated standardized incidence ratios (SIRs) for cancer among 47,000 widows/widowers and 60,000 divorced people, based on the Swedish Family-Cancer Database. Persons had to be identified with the same civil status in the census of years 1960 and 1

Expanding the Protection of Children's Rights towards a Dignified Life: : The Emerging Jurisprudential Developments in the Americas

The Inter-American Court of Human Rights (IACrtHR) has developed in recent years an innovative jurisprudence that has integrated the entity and extension of States’ obligations regarding children’s rights—as established in Article 19 ACHR—through the evolutive, dynamic, and effective interpretation of the American Convention on Human Rights (ACHR). In fact, by acknowledging the existence of an int

Natural Language Response Formats for Assessing Depression

OBJECTIVE:Recent advances in AI-based Large Language Models (LLM) can transform individuals’ descriptions of emotional health into numeric representations that predict rating scales with an accuracy approaching theoretical upper limits. This advancement enables examing various open-ended response formats. We develop and evaluate formats ranging from closed to more open: 1) selecting descriptive wo

AI lesion risk score at different exposure settings

Purpose: The purpose of this study was to investigate whether the lesion risk score provided by an AI system is influenced by the selection of exposure parameters. Methods: A breast phantom which contains a lesion, was imaged with digital mammography with different imaging conditions. The tube voltage, the dose level and the anode-filter combination were varied based on an exposure obtained with a

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Saco-rådet Umeå kommun KALLELSE 2015-02-27 Saco-rådsrepresentanter/ Saco-medlemmar KALLELSE TILL SACO-RÅDETS ÅRSMÖTE Tid Tisdag 2015-03- 24 kl. 17.00 Plats Ägirs gästabud, Folkets hus (1 tr ner) Program Årsmöte. I samband med årsmötesförhandlingarna bjuder Saco-rådet på krämig fisksoppa med grönsaker, färskost och bröd samt kaffe. Önskas specialkost meddelas det i samband med anmälan. Anmälan Sena

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/umea-kommun/dokument/arsmoteshandlingar-2015.doc - 2026-05-31

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Litteratur och film om första världskriget och mellankrigstiden Litteratur: Erich Maria Remarque, På västfronten intet nytt (filmatiserad 1930 och 1979) Alfred Döblin, Berlin Alexanderplatz (även som tv-serie regisserad av Rainer Werner Fassbinder) Robert Graves, Farväl till alltihop Ernest Hemingway, Farväl till vapnen (filmatiserad 1932, 1957, 1966) Ernest Hemingway, Klockan klämtar för dig (fil

https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISA17/20171/Litteratur_och_film_WWI.docx - 2026-05-31

03MOD_Magnusson_LTH-konferens_2025

03MOD_Magnusson_LTH-konferens_2025 LTH:s 13:e Pedagogiska Inspirationskonferens, 4 december 2025 Abstract— Många (fysik)laborationer på universitetsnivå är detaljerat styrda och inriktade på att bekräfta teori med siffror. I det här exemplet vänder vi på perspektivet och låter studenterna utforska ett fenomen utan mätinstrument, med fokus på vad de faktiskt observerar. Studenterna släpper en fotbo

https://www.lth.se/fileadmin/cee/genombrottet/konferens2025/C2_Magnusson.pdf - 2026-05-31

 Utformning av examinationssystem – konsekvenser för studenternas studier och lärares arbete Åsa Lindberg-Sand och Thomas Olsson Sammanfattning—Examinationssystem är komplicerat upp- byggda och regleras på många olika nivåer. De får ofta vidare konsekvenser för studenternas lärande och för lärares pedago- giska arbete än vad som kan avläsas om man fokuserar enskilda prov och bedömningar under utb

https://www.lth.se/fileadmin/lth/genombrottet/konferens2005/Proc05/UtformningExaminationssystem.pdf - 2026-05-31

Skatt som hållbarhetsfråga - En studie om det personliga ansvaret i förhållande till utvidgade rapporteringskrav för stora bolag

I takt med att världen globaliseras allt mer uppstår också nya typer av utma-ningar. Skatteplanering och skatteflykt orsakar idag stor skada på länders skattebas. För att motverka detta har OECD sedan 2013 arbetat med ett pro-jekt som kallas för BEPS (Base Erosion and Profit Shifting). BEPS består av 15 åtgärder för att motverka erodering av skattebasen och vinstallokering. Projektet har beskrivitAs the world becomes increasingly globalized, new types of challenges arise. Tax planning and tax evasion continue to cause significant harm to the tax bases of countries. To combat this, the OECD has been working on a project called BEPS (Base Erosion and Profit Shifting) since 2013. BEPS consists of 15 actions aimed at countering the erosion of the tax base and profit shifting. The project has b

Lunds universitet

Lunds universitet KN230817 Lunds universitet HT 2023 Språk- och litteraturcentrum LIVA14; LIVB10 Delkurs 1. Litteraturvetenskapens grunder. (7,5 hp) Lärare: Karin Nykvist, karin.nykvist@litt.lu.se Schema med läsinstruktioner Vecka 35 Mån 28 aug Obligatoriskt intromöte (Paul Tenngart med flera) 15-17, LUXB251 Tis 29 aug 10-11 LIVA14 grupp 1: Biblioteksundervisning med Kristina Nilsson Samling vid r

https://www.sol.lu.se/media/utbildning/dokument/kurser/LIVB10/20232/LIVA14dk1ht23schema.pdf - 2026-05-04