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Identifying genes that regulate polygenic diseases influenced by the environment such as rheumatoid arthritis (RA), has so far proven to be difficult. By using an alternative approach, i.e., linkage analysis using relevant animal models we succeeded in finding the Ncf1 gene residing in the Pia4 quantitative trait locus to be responsible for the severity of pristane induced arthritis in rats. The i
The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar
Den 7:e oktober 2019 publicerade Europarådet ett pressmeddelande, ”Better protection of whistle-blowers: new EU-wide rules to kick in in 2021”. I pressmeddelandet framgick det att ett nytt direktiv, Visselblåsardirektivet, skulle komma att förbättra skyddet för visselblåsare. Samtidigt arbetade företag och myndigheter fortfarande hårt för att anpassa sig till den relativt nya dataskyddsförordningeOn the 7th of October 2019, the Council of Europe published a press release, “Better protection of whistle-blowers: new EU-wide rules to kick in in 2021”. In the press release, the Council of Europe stated that a new directive, the Whistleblower Protection Directive, would increase protection of whistle-blowers. At the same time, companies and authorities were still struggling with the complicated
Popular Abstract in Swedish Varje år drabbas cirka 8000 svenska kvinnor av bröstcancer, och antalet nyinsjuknade ökar årligen med någon procent. I Sverige idag finns fler än 90 000 kvinnor som har avslutat eller är under behandling för sjukdomen. Med hjälp av nya återfallsförebyggande läkemedel har prognosen kraftigt förbättrats och 5-årsöverlevnaden är nästan 90 %. Den stora utmaningen i dagens bOne of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. This thesis describes studies on the effect of amplified in breast cancer 1 (AIB1), a coactiv
Despite the considerable import of both response probability and response time for testing models of choice there is a dearth of chronometric studies of time- and space-order effects in discrimination of paired visual stimuli. In this study, systematic asymmetries in discriminating the brightness of paired visual stimuli are examined by way of binary response probability scaled in terms of log-odd
Popular Abstract in Swedish C1q, en delkomponent av C1 molekylen, och mannan-bindande protein (MBL) är igenkänningsmolekyler i komplementsystemet. De har likartad struktur. C1q binder till IgG och IgM och aktiverar den klassiska vägen. MBL binder till kolhydratstrukturer och aktiverar lektinvägen. Autoantikroppar mot C1q förekommer ofta vid svår systemisk lupus erythematosus (SLE) och förekommer oThe C1 subcomponent C1q and the mannan-binding lectin (MBL) are recognition proteins of the complement system, and have similar structure. C1q binds to IgG and IgM and activates the classical pathway. MBL binds to carbohydrate structures and activates the lectin pathway. Autoantibodies to C1q are frequently found in severe systemic lupus erythematosus (SLE) and are present in virtually all patient
BACKGROUND: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer (HNC). However, most studies have used self-reported anthropometry which is prone to error.METHODS: Among 363 094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cas
Entre 2009 et 2011 nous avons mené un projet de recherche à l’université de Lund (Suède) intitulé L'âge de début d’acquisition et le développement linguistique en français (Schlyter/Granfeldt) dont le but était de comparer le développement linguistique du français de trois groupes d’enfants : des enfants monolingues (L1), des enfants bilingues simultanés (2L1) et des enfants ayant le français comm
The year 1937 saw the establishment of Congress Ministries in eight of the eleven provinces in which the provincial elections had been held, Bihar being one of them. The resounding victory of the Congress which secured a clear majority in the province of Bihar and the dismal performance of the Muslim League seemed at the time to depict the mood of the people in general. It was taken as a clear rej
Objectives: To evaluate whether anthropometric parameters add to PSA measurements in middle-aged men for risk assessment of prostate cancer (PCa) diagnosis and death. Results: After adjusting for PSA, both BMI and weight were significantly associated with an increased risk of PCa death with the odds of a death corresponding to a 10 kg/m2 or 10 kg increase being 1.58 (95% CI 1.10, 2.28; p = 0.013)
This article describes field monitoring and supplementary simulations of an existing daylighting and electric lighting integrated design for a furniture store. First in its type, the store includes several areas of the showroom provided with abundant daylighting. For the monitoring, the areas of the living rooms and the home decoration exhibitions were selected. They include wide glazed areas, day
Muhammad 'Abduh (1849-1905) was one of the key thinkers and reformers of modern Islam who has influenced both liberal and fundamentalist Muslims today. 'Abdul-Baha (1844-1921) was the son of Baha'ullah (1817-1892), the founder of the Baha'i Faith; a new religion which began as a messianic movement in Shii Islam, before it departed from Islam. Oliver Scharbrodt offers an innovative and radically ne
