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Although N- and P-type Ca2+ channels predominant in fast-secreting systems, Lc-type Ca2+ channels (C-class) can play a similar role in certain secretory cells and synapses. For example, in retinal bipolar cells, Ca2+ entry through the Lc channels triggers ultrafast exocytosis, and in pancreatic beta-cells, evoked secretion is highly sensitive to Ca2+. These findings suggest that a rapidly release

As multimedia- and group-oriented computing becomes increasingly popular for the users of wireless mobile networks, the importance of features like quality of service (QoS) and multicasting support grows. Ad hoc networks can provide users with the mobility they demand, if efficient QoS multicasting strategies are developed. The ad hoc QoS multicasting (AQM) protocol achieves multicasting efficienc

b1 integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were

Meningitis caused by Escherichia coli K1 is a serious illness in neonates with neurological sequelae in up to 50% of survivors. A high degree of bacteremia is required for E. coli K1 to cross the blood-brain barrier, which suggests that the bacterium must evade the host defence mechanisms and survive in the bloodstream. We previously showed that outer membrane protein A (OmpA) of E. coli binds C4b

Infections frequently consist of more than one strain of a given pathogen. Experiments have shown that co-infecting strains often compete, so that the infection intensity of each strain in mixed infections is lower than in single strain infections. Such within-host competition can have important epidemiological and evolutionary consequences. However, the extent of competition has rarely been inves

Background: S100A9 has been shown to be important for the function of so called Myeloid Derived Suppressor Cells (MDSC). Cells with a similar phenotype are also involved in pro-inflammatory processes, and we therefore wanted to investigate the gene expression and function of these cells in animals that were either subjected to chronic inflammation, or inoculated with tumors. Methods: CD11b(+)Ly6C(

The metabolic syndrome (MS) includes a clustering of metabolic derangements. Low testosterone levels have been shown to be associated with both components of MS and MS per se. As most androgen-related effects are mediated thorough the androgen receptor (AR), we wanted to investigate to which degree the AR CAG and GGN repeat polymorphisms might be related to MS. Sixty-eight men, 60-80 years old, wi

NKT cells m the mouse recognize antigen in the context of the MHC class I-like molecule CD1d and play an important role in peripheral tolerance and protection against autoimmune and other diseases NKT cells are usually activated by CD1d-presented lipid antigens However, peptide recognition m the context of CD 1 has also been documented, although no self-peptide ligands have been reported to date H

Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA aggregate. Using in situ null ellipsometry and neutron

Core-shell (CS) quantum dots (QDs) are promising light absorbers for solar cell applications mainly because of their enhanced photostability compared with bare QDs. Moreover, the superb photostability can be combined with a low number of defects by using CSQDs with a gradient composition change from the core to the shell. Here, we study electron injection from the gradient CSQDs to ZnO nanoparticl

Popular Abstract in Swedish Blodet är sammansatt av många olika typer av mogna celler som är ansvariga för specialiserade roller inom blodsystemet. Röda blodceller transporterar syre till kroppens celler, vita blodceller förser oss med försvar mot mikroorganismer och blodplättar ser till att stoppa blödningar. Nybildning av blodceller behövs kontinuerligt eftersom vissa celler lever bara i några dThe blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge

Apoptosis, followed by rapid phagocytic clearance, is the primary mechanism by which organisms dispose of unwanted cells. The intracellular and extracellular composition of an apoptotic cell changes to decrease immunogenicity and enhance its uptake. By changing their extracellular composition, apoptotic cells acquire the capacity to bind complement initiation molecules such as C1q and MBL. Binding

The purpose of this research is to examine the implications of the provisions in the Swedish Code of Corporate Governance (the Code) concerning auditor attestation of the internal control report. We will focus on how the auditors’ augmented responsibilities will affect the efficiency in the audit process.Our research indicates that the main benefit from reviewing the internal control report is ach

Syftet med vår studie är att undersöka de problem som kan uppstå vid en överföring av ett styrinstrument, innehållande Key Performance Indicators, från en organisation till en annan i samband med förvärv. Uppsatsen utgår från en fallstudie av ett företag i kemibranschen. I vår fallstudie använder vi ett abduktivt angreppssätt och en kvalitativ metod. I den teoretiska referensramen utgår vi ifrån t

Women immigrating with their children are a vulnerable group often exposed to ill health and a bad environment. In Europe, women from the Middle East have a complex situation, but immigrant women from low socioeconomic status backgrounds are at highest risk, also with regard to the perinatal period in life. In Sweden, all women independent of their immigrant status are offered free high-quality pe