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In adult mice, the VpreB genes are expressed in bone marrow progenitor (pro-) and precursor (pre-) B cells. As part of the pre-B cell receptor, the proteins are crucial for the proliferation of these cells and consequently normal B lymphocyte development. Using cell lines, we identified a lineage- and developmental-stage-specific VpreB1 enhancer. Here, we analyze its specificity in vivo by generat

Rationale: Patients with obesity hypoventilation syndrome (OHS) have high risk of hospitalization, which might be decreased by home mechanical ventilation (HMV). Objectives: To evaluate annualized hospitalization rate (AHR) and changes in AHR in patients with OHS starting HMV and explore if there were any differences in AHR by starting HMV acutely or electively. Methods: This was a population-base

Digitalization poses significant challenges to the EU VAT system, as it does in other areas of law. These challenges can be broadly divided into two main categories: those stemming from transformations in the economy, and those related to the legislative responses to these changes. In the VAT context, the first category includes the growing volume of transactions—particularly cross-border transact

Magnesium (Mg) is an abundant metal which has been used in aviation, medicine, hydrogen energy storage, etc. However, Mg can be rather reactive, and therefore an improved understanding of corrosion and oxidation mechanisms can enhance the efficiency of these processes to control and widen applications. The study presented here investigates the mechanisms of oxidation from the initial to full monol

Caenorhabditis nematodes, particularly the well-known Caenorhabditis elegans, have challenged early views of them as hard-wired by demonstrating diverse learning and memory capabilities. This cognitive repertoire, developed with just several hundred neurons, highlights the evolutionary importance of cognitive traits. In this study, we examine the relationship between learning, development, reprodu

Rock singing - five vocal teachers´ experience of the female voice. The purpose of this study is to find out what different vocal teachers have to say about rock singing and the female singing voice. The method I have used to gather information is a phenomenographically inspired qualitative interview. The study begins with a few thoughts about my interest in rock singing, followed by a short over

A controlled experiment was carried out by doing geophysical measurements on a purpose-built heap consisting of two different industrial waste fractions, called NF ( non-ferrous metal) and SLF (shredder light fraction), from the recycling plant of Stena Metall in Halmstad, Sweden. The purpose of the experiment was to see if it was possible to distinguish the different types of material using geoph

We performed high-resolution simulations of two stellar collisions relevant for stars in globular clusters. We considered one head-on collision and one off-axis collision between two 0.6-Msolar main-sequence stars. We show that a resolution of about 100000 particles is sufficient for most studies of the structure and evolution of blue stragglers. We demonstrate conclusively that collision products

A quarter of DA white dwarfs are metal polluted, yet elements heavier than helium sink down through the stellar atmosphere on time-scales of days. Hence, these white dwarfs must be the currently accreting material containing heavy elements. Here we consider whether the scattering of comets or asteroids from an outer planetary system, following stellar mass-loss on the asymptotic giant branch, can

It has been argued that, when there is a probable imminent risk of loss of children's fertility, their parents should take active steps to preserve their reproductive potential if possible – or even that children have a right to such interventions being undertaken on them on their behalf, as an expression of their right to an open future. In this chapter, I explore these proposals and some of thei

The stellar-to-halo mass relation (SHMR) is not only one of the main sources of information we have on the connection between galaxies and their dark matter haloes, but also an important indicator of the performance of galaxy formation models. Here, we use one of the largest sample of galaxies with both high-quality rotation curves and near-infrared surface photometry, and perform a detailed compa

Infections due to the opportunistic fungus Candida have been on the rise in the last decades, especially in immunocompromised individuals and hospital settings. Unfortunately, the treatments available today are limited. Thrombin-derived C-terminal peptide (TCP-25) is an antimicrobial peptide (AMP) with antibacterial and immunomodulatory effects. In this work, we, for the first time, demonstrate th

The two-dimensional (2D) affinity between protein molecules across contacting cells is a key parameter regulating and initiating several cellular processes. However, measuring 2D affinity can be challenging, and experimental data are limited. In addition, the obtained 2D affinities are typically averaged over the cell population. We here present a method to measure 2D affinity on single cells bind

This review aims to provide a comprehensive overview of the in vitro, animal, and clinical studies with the bacterial strain Lactiplantibacillus plantarum 299v (L. plantarum 299v; formerly named Lactobacillus plantarum 299v) published up until June 30, 2020. L. plantarum 299v is the most documented L. plantarum strain in the world, described in over 170 scientific publications out of which more th

This paper reviews the current literature regarding iron oxide formation in the wheel-rail contact in order to assess the possible role of iron oxides in the “Wet-Rail” phenomenon, which causes low adhesion between the wheel and the rail. The paper discusses the structure and formation of oxides from a chemical perspective before analysing the direct tribological effects and outlining the techniqu