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Fructans—fructose-based oligo- or polysaccharides—are de novo synthesized from sucrose by transfructosylating enzymes of microorganisms and plants. Fructan-producing enzymes belong to glycoside hydrolase families 32 and 68. Levansucrases, inulosucrases, some invertases, sucrose:sucrose 1-fructosyl transferases, fructan:fructan 1-fructosyl transferases, sucrose:fructan 6-fructosyl transferases and
INTRODUCTION: Patients with non-small cell lung cancer (NSCLC) faced an elevated risk for severe COVID-19 outcomes and were prioritized for early vaccination. However, immune responses to SARS-CoV-2 vaccines remain poorly characterized in this group, especially in patients receiving immune checkpoint inhibitor PD-1/PDL-1 (ICI) therapy.MATERIALS AND METHODS: In this prospective observational study,
BACKGROUND: Prognostication of recovery in patients who are unconscious following cardiac arrest can be guided by concentrations of brain injury biomarkers in the blood. The optimal biomarker and cutoff concentrations for the prediction of outcome remain unknown. In this study, we aimed to evaluate which biomarker of brain injury is most accurate for predicting functional outcome after cardiac arr
This article explores the intricate relation between translation and the Nobel Prize in Literature through the lens of a special case: the 1939 award to Finnish novelist Frans Eemil Sillanpää. The discussions in the Nobel committee, and the decision of the Swedish Academy to select Sillanpää for the prize, were deeply affected by the long and complicated political and cultural history of neighbors
What is the situation in Indian agriculture today? What has happened to production and distribution of land since independence? What has happened after the liberalisation of the Indian economy in the 1990s?
During the past few years we have seen an impressive number of studies using directed self-Assembly in soft matter research with a surprisingly wide range of underlying aims and goals. Here we will focus on field-driven colloidal selfassembly, and demonstrate how we can apply external electromagnetic fields in order to modulate the intrinsic interparticle interactions and induce additional directi
The capture of human acute mycloid leukemia KG-1 cells expressing the CD34 surface antigen and the fractionation of human blood lymphocytes were evaluated on polyvinyl alcohol (PVA)-cryogel beads and dimethyl acrylamide (DMAAm) monolithic cryogel with immobilized protein A. The affinity ligand (protein A) was chemically coupled to the reactive PVA-cryogel beads and epoxy-derivatized monolithic cry
The present study focuses on in situ as well as ex situ studies on the sintering of pre-compacted powder mixtures of 50 at% Nickel-50 at %Titanium. In situ studies were carried out by monitoring the changes in morphology of the fracture surface of the compact continuously during heating in the hot stage of an environmental scanning electron microscope. Results on the initiation of sintering and it
Background: The strongest risk factor for falls is a history of falls. Therefore, interventions targeting persons at risk of falling before they are aware of the risk themselves is highly demanded. The prevention of falls is a complex task and has no easy solutions; an interdisciplinary approach is necessary. Modern technology provides us with novel opportunities to detect and monitor falls and ne
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve
Analysis of antibody repertoire development and specific antibody responses important for e.g. autoimmune conditions, allergy, and protection against disease is supported by high throughput sequencing and associated bioinformatics pipelines that describe the diversity of the encoded antibody variable domains. Proper assignment of sequences to germline genes are important for many such processes, f
P>Diagnosing candidaemia remains difficult despite the development of new diagnostics. We report a direct comparison of three different blood-culture systems and four indirect tests. One hundred and fourteen episodes either with haematological disease and fever despite antibacterials, or with documented invasive candidiasis, were enrolled prospectively. Clinical, para-clinical information and surv
