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Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A,

Autoantibodies to glutamate decarboxylase 65 (GAD65Ab) are commonly believed to be a major characteristic for type 1 diabetes (T1D). We investigated the presence of GAD65Ab in healthy individuals (n = 238) and first-degree relatives (FDRs) of T1D patients (n = 27) who tested negative for GAD65Ab in conventional RIAs. Sera were applied to affinity columns coated with GAD65-specific mAbs to absorb a

Rysk-amerikanska Emma Goldman och kinesiska He-Yin Zhen kom från två olika delar av världen och var aktiva inom olika kunskapstraditioner och kulturer. Ändå var de båda anarkister som kämpade för kvinnlig frigörelse, och båda var de kritiska till de samtida rörelserna som stred för kvinnors politiska rättigheter. Det finns få studier som jämför tidig amerikansk feminism med tidig kinesisk feminismRussian-American Emma Goldman and Chinese He-Yin Zhen came from different parts of the world, and thus weren’t active within the same knowledge systems and cultures. However, they were both anarchists fighting for the liberation of women, and both were strongly criticising the contemporary women’s suffrage movements. Few comparisons have been made between early Chinese feminism and early American

Utveckling av en metod för att kartera högsta kustlinjen i Sverige med hjälp av brytlinjer extraherade från högupplösta höjdmodeller Högsta kustlinjens (HK) geografiska läge i landskapet markerar gränsen mellan subakvatiskt och supraakvatiskt avsatta sediment. Idag varierar HKs höjd över havet från några få m.ö.h. i Skåne till omkring 289 m.ö.h. i Ångermanland på grund av den glacialisostatiska lDevelopment of a method for mapping the highest coastline in Sweden using breaklines extracted from high resolution digital elevation models The geospatial position of the highest coastline (HCL) defines the boundary between subaquatic and supra-aquatic deposited sediments. Today the HCL is located at different elevations throughout Sweden, a few m.a.s.l. in southern Scania to around 289 m.a.s.l.

Based on the Synchrotron Radiation (SR) beamline optical element-by-element alignment with analysis of the alignment results an optimized beamline alignment algorithm has been designed and developed. The alignment procedures have been designed and developed for the MAX-lab 1911-4 fixed energy beamline. It has been shown that the intermediate information received during the monochromator alignment

Solar cells based on organometal halide perovskites have seen rapidly increasing efficiencies, now exceeding 15%. Despite this progress, there is still limited knowledge on the fundamental photophysics. Here we use microwave photoconductance and photoluminescence measurements to investigate the temperature dependence of the carrier generation, mobility, and recombination in (CH3NH3)PbI3. At temper

S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation end-products (RAGE) interacts with both S100A9 and S100A4. Furthermore, we show that S100A9 and S100A4 interact with RAGE and TLR4; interac

Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarb

Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet a

The perforated whole-cell configuration of the patch-clamp technique was applied to functionally identified beta-cells in intact mouse pancreatic islets to study the extent of cell coupling between adjacent beta-cells. Using a combination of current- and voltage-clamp recordings, the total gap junctional conductance between beta-cells in an islet was estimated to be 1.22 nS. The analysis of the cu

This paper is intended to give a short overview of the epidemiologic and experimental data on cancer risks associated with very low radiation absorbed doses. The paper will also discuss methods to present these data in an understandable way to those who are exposed e. g. in medical diagnostics and after a radiological or nuclear accident.

The paper identifies three interconnected scales of global politics in Artificial Intelligence (AI) and healthcare. It provides a multilevel framework for policy makers to situate hybrid-human AI collaborations in healthcare within broader global political concerns.

Work in developmental pragmatics has shown that even though infants display refined mindreading abilities, older children struggle to understand language phenomena that rely on mindreading. This apparent mismatch might be partially explained by considering children's growing sensitivity to social categories such as their interlocutor's age. Based on recent work in philosophy of mind, we investigat

Background: In this study we included patients with hereditary angioedema (HAE) caused by decreased levels of C1 inhibitor (HAE-C1INH). An increased risk of autoimmune disorders, particularly systemic lupus erythematosus (SLE), has been reported in HAE-C1INH. This suggests that complement consumption affects adaptive immunity. Objective: To investigate lymphocyte subpopulations in relation to dise

New recommendations for environmental noise levels have been issued in Sweden. The permissible levels at facades of new buildings have been increased, which has resulted in a risk for higher indoor low frequency noise levels, since the recommended indoor levels are A-weighted. The additional Swedish low frequency third octave band requirements might be violated. Therefore, there is a need for revi

Latent autoimmune diabetes of the adults (LADA) accounts for up to 12% of all patients with diabetes. Initially the disease resembles type 2 diabetes (T2D); however, the typical presence of β cell autoantibodies indicates an autoimmune basis of LADA. While dysfunctional regulatory T cells (Tregs) have been implicated in autoimmune diabetes, these cells have been scarcely studied in LADA. The aim o

INTRODUCTION. The diagnosis of acute lung injury may be more robust if more accurate physiological markers can be identified. Extravascular lung water index (EVLWI) may be useful and has been shown to correlate with respiratory function and mortality in patients with sepsis and ARDS. Whether this applies to a wider population, and which index performs best, are unclear. OBJECTIVES. We hypothesized

Flexibility of the energy system plays a vital role when integrating non-dispatchable renewable energy technologies. However, flexibility of the energy system has been often discussed only focusing on the operation of the energy system. This study extends the flexibility concept considering both design and operation of the energy system. In order to achieve this, pseudo chronological scenarios use

Accurate diagnosis of histological type is important for therapy selection in lung cancer. Immunohistochemical (IHC) and histochemical stains are often used to complement morphology for definite diagnosis and are incorporated in the WHO classification. Our main aim was to compare different mucin stains and assess their value in relation to common IHC analyses in lung cancer diagnostics. Using tiss