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Akt (also known as PKB) is a survival kinase frequently up-regulated in cancer; three isoforms of Akt exist, and among them Akt1 and Akt2 are the most widely and highly expressed. They share the same structure and activation mechanism and have many overlapping functions; nevertheless isoform-specific roles and substrates have been reported, which are expected to rely on sequence diversities. In pa
We examine the applicability of the extended law of corresponding states (ELCS) to equilibrium and non equilibrium features of the state diagram of the globular protein lysozyme. We provide compelling evidence that the ELCS correctly reproduces the location of the binodal for different ionic strengths, but fails in describing the location of the arrest line. We subsequently use Mode Coupling Theor
Popular Abstract in Swedish Om blodkärlen i ögat läcker eller om blodflödet stoppas får inte näthinnan den mängd syre och näring som den behöver. Detta tillstånd kallas ischemi och kan leda till att näthinnans celler skadas. Näthinnan ligger längst bak i ögat och fungerar som filmen i en kamera. Stavar och tappar registrerar ljus och signalen går via nerver till syncentra i hjärnan. Blodkärl (artäIdentification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. The porcine eye has a typical primate-like architecture and is similar to the hum
The PHENIX experiment at RHIC has embarked on a broad range of upgrades to enhance its physics reach. One of the upgrades consists of a set of silicon vertex trackers that combine to cover the pseudorapidity range − 2.4 to 2.4. A description of the vertex detectors and some of their physics goals and capabilities will be given, as well as technology choices and results from prototype components.
Abstract: In the interface, between implant and bone or between the cement and bone, there will develop some amount of fibrous tissue. The synovial fluid, the synovium, the cartilage and the subchondral bone from the non-replaced knee compartment that had been exposed to wear particles were studied by histological analyses. These analyses showed polyethylene wear particles in all tissues except t
To increase the accuracy of molecular force fields a systematical and balanced improvement of the various terms included is needed. In this work, we have followed this strategy to improve the quality of the NEMO potential for the formaldehyde dimer by introducing local quadrupole moments and higher-order polarizabilities. It is found that inclusion of the quadrupole moment significantly improves t
How can revealing the past at historic sites benefit our society? This question has been discussed recurrently over the years within heritage studies and heritage practices; the suggested answers are many. This text analyses what has been remembered and forgotten in an urban development process, when the previously industrial area of Lomma Eternit in south Sweden was turned into a luxury residenti
To date there is no International standard on the verification and validation (V&V) of building fire evacuation models, i.e., model testers adopt inconsistent procedures or tests designed for other model uses. For instance, the tests presented within the MSC/Circ.1238 Guidelines for evacuation analysis for new and existing passenger ships provided by the International Maritime Organization are
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusi
The article considers the importance of frontier studies in historical archaeology and discusses applicability of some of the concepts deriving from postcolonial theories for a better understanding of human relationships in the frontier zones. The conditions of frontiers and borderlands are compared with the characteristics of the “Third Space” described by Homi Bhabha as a realm of negotiation, t
In this article I address the significance of semiotic processes supporting early social interaction, communication and learning in the evolution of the modern human niche of infancy and childhood, known to be extended even in comparison with closely related hominin species. Human infancy and childhood is a biocultural niche, embedded within and causally contributing to the expansion and elaborati
High-multiplicity proton-proton collisions at the LHC may exhibit collective phenomena such as elliptic flow. We study this issue using DIPSY, a brand-new Monte Carlo event generator which features almost-NLO BFKL dynamics and describes the transverse shape of the proton including all fluctuations. We predict the eccentricity of the collision as a function of the multiplicity and estimate the magn
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis
To improve the accuracy and transferability of molecular mechanics force fields, one needs a simple physical description of intermolecular polarization based on quantum chemistry. Ideally, in the quantum-chemical description, each molecule is treated separately and the interactions with other molecules are included as a perturbation. We propose a simple formulation of this perturbation, viz. to mo
HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799
The quality of powder is determined by its functionality such as dissolution, encapsulation and flowability. The functionality of powder is in turn determined by their primary properties such as morphology and composition which need to be studied. Hence morphology and surface composition has been largely investigated in spray dried powders and individually dried particles. On the contrary, there i
The post-war years were a time of expansion in Swedish publishing. The economy was growing, people became better educated, the rise of a large middle-class meant new costumers, new publishing and sales strategies added to the increasing market, and overall there was higher sales, more titles published and more people reading. Despite the success story there has been hardly any research done on the
Popular Abstract in Swedish Hemolytiskt uremiskt syndrom (HUS) är den vanligaste orsaken till njursvikt bland barn i västvärlden. HUS kännetecknas av hemolytisk anemi (sönderfall av och brist på röda blodkroppar), trombocytopeni (brist på blodplättar) och akut njursvikt. Den vanligaste formen av sjukdomen, typisk HUS orsakas av Shigatoxinproducerande bakterier, främst olika stammar av EscherichiThis thesis addressed the diagnosis, pathogenesis and clinical course of specific renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD). HUS may be associated with infection caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). EHEC is a non-invasive highly virulent bacterium
