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Time-domain spectroscopy encompasses a wide range of techniques, such as Fourier-transform infrared, pump-probe, Fourier-transform Raman, and two-dimensional electronic spectroscopies. These methods enable various applications, such as molecule characterization, excited state dynamics studies, or spectral classification. Typically, these techniques rarely use sampling schemes that exploit the prio
Recently, many forms of audio industrial applications, such as sound monitoring and source localization, have begun exploiting smart multi-modal devices equipped with a microphone array. Regrettably, model-based methods are often difficult to employ for such devices due to their high computational complexity, as well as the difficulty of appropriately selecting the user-determined parameters. As a
Precise epitope determination of therapeutic antibodies is of great value as it allows for further comprehension of mechanism of action, therapeutic responsiveness prediction, avoidance of unwanted cross reactivity, and vaccine design. The golden standard for discontinuous epitope determination is the laborious X-ray crystallography method. Here, we present a combinatorial method for rapid mapping
Many forms of small-size radars suffer from minor clock oscillations due to crystalline impurities in their internal clocks, causing time-varying clock offsets between the transmitter and the receivers. This offset causes a bias and an increased variance in the positioning of close-range targets, limiting the achievable accuracy well beyond the expected estimation limitations. This performance is
This paper develops an adaptive grid two-dimensional (2-D) direction-of-arrival (DOA) estimation technique employing an integrated dictionary framework. In contrast to using a traditional grid over distinct angles, combined angle information atoms are adopted to construct the dictionary, using a SPICE-based noise power estimate to select the active regions. To compensate for off-grid bias effects,
BACKGROUND: Problems in social functioning (e.g., unemployment, social isolation), are common in people with a psychotic disorder. Social cognition is a treatment target to improve social functioning, as it is a proximal predictor of social functioning. Social Cognition Training (SCT) improves social cognition, but may not generalize (enduringly) to social functioning, perhaps due to insufficient
Post-marketing reports of suspected adverse drug reactions are important for establishing the safety profile of a medicinal product. However, a high influx of reports poses a challenge for regulatory authorities as a delay in identification of previously unknown adverse drug reactions can potentially be harmful to patients. In this study, we use natural language processing (NLP) to predict whether
The axillary lymph node status remains an important prognostic factor in breast cancer, and nodal staging using sentinel lymph node biopsy (SLNB) is routine. Randomized clinical trials provide evidence supporting de-escalation of axillary surgery and omission of SLNB in patients at low risk. However, identifying sentinel lymph node macrometastases (macro-SLNMs) is crucial for planning treatment ta
This article addresses the problem of multi-target localization from acoustic time delay measurements in a 3-D underwater environment, taking into account the depth-dependent sound speed of the underwater wave propagation. Specifically, we formulate the problem as an optimal mass transport (OMT) optimization over a grid of potential candidate positions. By exploiting an iterative refinement approa
The separation of multiple transmit waveforms with time and frequency synchronization constitutes a considerable challenge for multiple-input multiple-output (MIMO) synthetic aperture radar (SAR) systems. It is well-known that aliased signal returns may be separable by digital beamforming (DBF) on receive in elevation. However, the current orthogonal-waveform beamforming schemes significantly incr
Background: Chronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systemic effects, e.g., heart failure or voice distortion. Howeve
Objective: To describe and compare hip and groin strength and function of male ice hockey players over one season in players with and without hip and groin problems in the previous season. Design: Prospective cohort study. Setting: Swedish male ice hockey. Participants: We followed 193 players from 10 teams during the 2017/2018 season. Main outcome measures: Hip adduction and abduction strength, 5
1,2-Addition of 3,4-methylenedioxymagnesium bromide to 2-(R) and (S)-benzyloxy-2,5-dihydro-4-furancarboxaldehyde, followed by oxidation, gave the title ketones (3r and 3s). Conjugate addition of the anions of 3,4,5-trimethoxy- and 3,4-methylenedioxybenzaldehyde diphenylthioacetal to 3r and 3s and Raney-nickel desulfurisation, followed by hydrogenolysis under various conditions, gave the title lign
Background: Primary spinal tumors are rare. Symptoms depend on the size and location of the tumor.Case description: A patient presented with a rare clinical finding, Brown-Séquard syndrome. The symptoms were caused by an extramedullary tumor compressing on the thoracic spinal cord. Pathologic examination showed cavernous hemangioma with growth both intradurally and extradurally.Conclusions: This i
The identification of nonlinear chirp signals has attracted notable attention in the recent literature, including estimators such as the variational mode decomposition and the nonlinear chirp mode estimator. However, most presented methods fail to process signals with close frequency intervals or depend on user-determined parameters that are often non-trivial to select optimally. In this work, we
Current literature show that frequency diverse arrays (FDAs) are able of producing range–angle-dependent and time-variant transmit beampatterns, but the resulting time and range dependencies and their characteristics are still not well understood. This paper examines the FDA transmission model with an emphasis on analyzing the beam auto-scanning characteristics and the equivalence with the MIMO be
In this paper, we considered the real-time modeling of an underwater channel impulse response (CIR), exploiting the inherent structure and sparsity of such channels. Building on the recent development in the modeling of acoustic channels using a Kronecker structure, we approximated the CIR using a structured and sparse model, allowing for a computationally efficient sparse block-updating algorithm
Background: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness.Methods: a cross-sectional analysis of the multicentre popu
Acoustic impulse responses (IRs) are widely used to model sound propagation between two points in space. Being a point-to-point description, IRs are generally estimated based on input-output pairs for source and sensor positions of interest. Alternatively, the IR at an arbitrary location in space may be constructed based on interpolation techniques, thus alleviating the need of densely sampling th
Acoustic testing is crucial in the aero-engine design process, providing valuable information about the sound field in terms of acoustic modes. The conventional use of a uniform sampling array limits the achievable resolution for a given number of sensors, necessitating the use of a large number of sensors to achieve high-resolution estimates. This limitation may be overcome using a non-uniform se
