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Pulmonary arterial hypertension (PAH) is a lethal condition where expansion of the vascular extracellular matrix contributes to increased pulmonary vascular resistance. Versican, a chondroitin sulfate proteoglycan, is known to accumulate in vascular lesions of PAH and hyaluronan and tenascin-C, binding partners of versican, are elevated in PAH. The specific distribution and localization of versica
This thesis explores the challenges and advancements in high-dimensional Bayesian optimization (HDBO), focusing on understanding, quantifying, and improving optimization techniques in high-dimensional spaces.Bayesian optimization (BO) is a powerful method for optimizing expensive black-box functions, but its effectiveness diminishes as the dimensionality of the search space increases due to the cu
The purpose of the risk management process, RiskUse is to provide practitioners, mainly risk managers with a software risk management process that has a well-defined user perspective. The aim is to present a risk management process that allows the development organisation to perform adequate risk management activities that can ensure that the developed software is safe from a user perspective.
The pathloss exponent and the variance of the large-scale fading are two parameters that are of great importance when modeling or characterizing wireless propagation channels. The pathloss is typically modeled using a single-slope log-distance power law model, whereas the large-scale fading is modeled using a log-normal distribution. In practice, the received signal is affected by noise and it mig
Massive multiple-input multiple-output (MIMO) is one of the main candidates to be included in the fifth generation (5G) cellular systems. For further system development it is desirable to have real-time testbeds showing possibilities and limitations of the technology. In this paper we describe the Lund University Massive MIMO testbed – LuMaMi. It is a flexible testbed where the base station operat
Issue management in market-driven software projects is constantly under time pressure. A limited set of developers must share their time between developing features for the next release and resolving reported issues. Project managers need to find the appropriate balance between a high quality product and fast time to market. We study a telecom company in Sweden developing embedded systems for a co
A Vernier Gate-Ring-Oscillator (GRO) Time to Digital Converter (TDC) is proposed and implemented in 90-nm CMOS process technology. It utilizes two GRO chains as the delay lines. The time resolution is determined by the difference between two delays, so not limited by the process. Moreover, the quantization noise can be first-order shaped by the gated behavior in the oscillators, which further impr
The limited volume of mobile handset and the phenomenon of chassis excitation complicate the design of multiple antennas for MIMO applications. In this work, a compact co-located dual-antenna system implemented on one edge of a 100 mm by 40 mm chassis is proposed for operation below 1 GHz. The dual-antenna structure includes a folded monopole to excite the fundamental electric dipole mode of the c
In this note, we deduce a bound between fast algebraic immunity and higher order nonlinearity (it is the first time that a bound between these two cryptographic criteria is given), and find that a Boolean function should have high r-order nonlinearity to resist fast algebraic attacks. As a corollary, we find that no matter how much effort we make, the Tu-Deng functions cannot be repaired in a stan
Code inspections and structural unit testing are two common defect detection methods in software development. This paper analyses three replications of an experiment aimed at comparing which method finds more defects. The first two experiments use the same experimental design and materials, including the programs to be inspected or tested, while the third experiment replaces the programs with code
This paper presents a high-speed QR decomposition (QRD) processor targeting the carrier-aggregated 4 × 4 Long Term Evolution-Advanced (LTE-A) receiver. The processor provides robustness in spatially correlated channels with reduced complexity by using modifications to the Householder transform, such as decomposing-target redefinition and matrix real-valued decomposition. In terms of hardware desig
In this paper we describe a scenario for supporting healthcare at home and identify some demands for intelligibility in this situation. In such a system we have identified a need for flexible adding and removing medical devices, and to support changing functionality depending on if a nurse is present or not. We suggest that this kind of variability can be addressed by introducing guards in our rul
