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Background: The Btk (Bruton's tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinases with distinct functional domains PH, TH, SH3, SH2, and kinase. Mutations have been observed in each of the Btk subdomains in XLA. We have analyzed the Btk gene in six XLA pa
We have examined long-term growth-factor expanded human neural progenitors following transplantation into the adult rat brain. Cells, obtained from the forebrain of a 9-week old fetus, propagated in the presence of epidermal growth factor, basic fibroblast growth factor, and leukemia inhibitory factor were transplanted into the striatum, subventricular zone (SVZ), and hippocampus. At 14 weeks, imp
Food-hoarding birds use memory to relocate caches, and species that store thousands of scattered food items must have an extraordinary memory capacity to be able to relocate them. Because the hippocampus is important in the functioning of spatial memory, it is logical to assume that the amount of food stored should correlate with hippocampal volume. Previously, food-hoarding capacity has been used
This project was conducted as a phenomenological study, focusing on organizational culture connected to communication, of the collaboration between the academic world and small private companies. The purposes were to get a deeper understanding of culture and communication and to use phenomenology as a research approach, to see what it can contribute with. Data collection was obtained by an intern
"The aim of this thesis is to study the implied volatility on certain warrants on the Nordic Derivatives Exchange and compare it to an EGARCH-forecasted volatility (which throughout the thesis is used as proxy for the true volatility by the authors) in order to see if the difference follows a specific pattern." The difference between the forecasted volatility and the implied volatility f
This essay aims to estimate the cost of hospitalisation in 2003 for Region Skåne for diseases fully attributable to alcohol. An included review of cost-of-illness studies of societal costs of alcohol misuse reaches the conclusions that comparability between studies has increased in recent years as a result, among others, of the establishing of international guidelines. Despite this, some problems
Summary Title: Taxes and Human Capital as Determinants of Foreign Direct Investment in EU: The role of Most Favoured Nation treatment Author: Andreas Helmersson Supervisors: Cecilé Brokelind and Rikard Larsson Problem discussion and problem Formulation: The recent year’s rapid increase in foreign direct investment (FDI) is a clear indication of increasing globalisation. In order to stay competitiv
Fulltext är ej tillgänglig i elektronisk form. För lån/kopia av tryckt uppsats kontakta Medicinska fakultetens bibliotek, Lunds universitet
Populärvetenskaplig sammanfattning: En tredjedel av våra kärlväxter, och inte mindre än två tredjedelar av de rödlistade arterna, återfinns i semi-naturliga gräsmarker. Under de senaste 150-200 åren har denna typ av område minskat med omkring 90 % i Sverige och de kvarvarande gräsmarkerna drabbas av både kvalitetsförsämringar, som följd av minskat bete, gödsling o.s.v., och av en ökad fragmenterinSemi-natural grasslands are amongst our most species rich habitat types and house many threatened plant and animal species. These grasslands suffer from both quality deteriorations due to abandonment, fertilization etc., and from an increasing landscape fragmentation. In fragmented areas patches are smaller and more isolated from each other. If the anthropogenic influence is high, then they also t
The purpose of this study was to develop an understanding of the individual and gendered experiences among young girls and boys who have migrated independently to the city of Kumasi in Ghana in search of work and better life opportunities. The research questions relate to their experiences of opportunities and constraints at destination; self-protection strategies that they employ to minimize nega
This theoretical reflections evaluates my own learning experiences during six months in the master program of entrepreneurship at Lund University. I will focus on how to carry out an entrepreneurial project alone and what importance networks have in this process. I will use four main areas of theory that I will discuss and analyze; The comparison between team start-ups and solo start-ups, networki
This Master’s thesis examines the outcomes of the new Free Choice policy with particular emphasis on whether giving residents the right to choose their providers of primary health care leads to a more equal distribution of primary health care accessibility. This study is based on the Secondary Analysis of assessment for vårdval (choice of health system) in Stockholm by Karolinska Institute (2010),
Då klimatförändringar studeras är det viktigt att ha markanvändningarna och deras förändringar i åtanke. Markanvändningarna är direkt och indirekt relaterat till klimatförändringar såsom exempelvis stigande temperaturer, vilket påskyndar starten av växtsäsongen. Fjärranalysdata ger en bättre bild av storskaliga förändringar i vegetationen än vad som är möjligt att observera från jordytan. VegetatiWith respect to climate change it is necessary to study land use and land cover (LULC) and their changes. LULC are related directly and indirectly to climatic changes such as rising temperatures that trigger earlier onset of vegetation growing seasons (IPCC 2007). Land surface phenology refers to the seasonal patterns of variation in vegetated land surfaces over large areas using satellite data (R
Here we examined the ability of human neural progenitors from the embryonic forebrain, expanded for up to a year in culture in the presence of growth factors, to respond to environmental signals provided by the developing rat brain. After survival times of up to more than a year after transplantation into the striatum, the hippocampus, and the subventricular zone, the cells were analyzed using hum
This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH(2)O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were reco
In interstadial deposits, sand interbeds gain limited consideration in comparison with organic sediments, and therefore tend to be underrepresented in paleoenvironmental reconstructions. The Raunis site, central-eastern Latvia, is an example where organic beds have already gained some attention and been used to understand the complex interactions between advance and retreat of the Scandinavian Ice
Neural stem cell populations generate a wide spectrum of neuronal and glial cell types in a highly ordered fashion. MicroRNAs are essential regulators of this process. T-UCstem1 is a long non-coding RNA containing an ultraconserved element, and in vitro analyses in pluripotent stem cells provided evidence that it regulates the balance between proliferation and differentiation. Here we investigate
