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The t(6;9)(p22;q34) chromosomal translocation is found in a subset of patients with acute myeloid leukemia (AML). The translocation results in a fusion between the nuclear phosphoprotein DEK and the nucleoporin NUP214 (previously CAN). The mechanism by which the fusion protein DEK-NUP214 contributes to leukemia development has not been identified, and disruptions of normal cellular functions by DE
Increasing incidence of testicular germ cell cancer (TGCC) is most probably related to environment and lifestyle. However, an underlying genetic predisposition may play a role and since sex steroids are assumed to be important for the rise and progression of TGCC, a study of androgen receptor (AR) gene polymorphisms in relation to the risk, histological type and progression of TGCC was undertaken.
Migration studies have generally focused either on broad drivers that are difficult to operationalize, such as quality of life and standard of living, or a few specific, predominantly economic, drivers. Hence, broader explanations for migration have been understudied, especially quantitively. Similarly, peace studies have traditionally favored narrow conceptualizations of peace. This study aims to
This study aims to investigate the difference in stock return between traditional sin stocks, new sin stocks, and their respective peer stocks. The purpose was to expand the scarcely researched area of new sin stocks by being the first one to focus on new sin stocks on the American stock market (United States NYSE, AMEX, and NASDAQ stock exchanges), as this area has only been researched in Europe
It is important to examine parent advocacy programs to understand how they function in a society where there are many structural obstacles to those with little power. These programs can provide an impactful way to level out power imbalances. This case study examined through a lens of legal consciousness theory, power and empowerment theory, and the four capitals as developed by Bourdieu, the pur
Departing from the question of how linguistic representations of sexual crime are connected to social practices around sexuality, this discourse analysis looks into 30 news articles on sexual crime to identify discourses around male and female sexuality. As most sexual crimes are committed by men and against women, the analysis focuses on connecting discursive descriptions of men and women in rela
Sylvia Plath’s The Bell Jar, Margaret Atwood’s The Edible Woman and Doris Lessing’s “To Room Nineteen” are three literary texts in which the three protagonists seem to play a role which makes them miserable and suicidal. This essay explores what elements that are involved in making these women unhappy and self-destructive. Based on a close reading of the three texts and Judith Butler’s theories on
Collapse of the Soviet Union and abolishment of the state atheism policy has led to an increase of Protestant organizations and their parishes in Ukraine. Some of them (at least fifteen) allow and practice women ordination. Women priests, thus, find themselves performing non-traditional gender roles in Ukraine, where the majority of the population is affiliated with Orthodox or Greek Catholic Chur
Geographical Information Systems are a powerful tool for the processing of geographical data and can be used to implement predictive modelling for the purpose of archaeological research. The study presented here proposes a predictive model based on multi-criteria evaluation, and aims at analysing the parameters of known Upper Palaeolithic decorated caves in the Périgord noir, in southwest France.
Cities around the world are not only facing the impacts of climate change but are also increasingly charged with the responsibility to adapt. The city of Malmö in Sweden, facing the consequences of ever-so-present pluvial floods, has set an objective to increase the use of multifunctional Nature-based Solutions (NBS) in its urban stormwater planning. Nevertheless, despite evidence pointing at the
Violation of Children´s Rights in the Area of Child Labour in Pakistan. Remedies Available under Domestic and International Law
Aim: The aim of this paper was to shed light on the different methods/strategies that Anti-Brand Communities (ABCs) use in order to cause harm to particular brands. Purpose: The purpose of this paper is to offer assistance to brand managers through Anti-Brand Community-insights, as a means of combating the increasingly growing number of ABCs. Research Question: What methods/strategies do anti-b
Allelopathy is a term first introduced by Hans Molisch in his 1937 book titled The Influence of One Plant on Another: Allelopathy and, as it stands, it is defined as the biological phenomenon through which growth, development, reproduction or survival of an organism are altered by the release of biochemicals from another. In this study, we investigate the allelochemical potential of leachates coll
Parkinson's disease (PD) is a neurodegenerative disease that is characterized by alpha-synuclein (α-syn) aggregations and loss of dopaminergic neurons. The cause for PD is still being researched but neuroinflammation has gained increasing awareness. Polymorphism in class II, major histocompatibility complex, transactivator (Ciita), which regulates major histocompatibility complex II (MHCII) ex
Background/introduction: E-commerce is becoming a natural part of retail business. In order to achieve a competitive edge, companies are shifting to omni channel retailing where channel integration is explored in the search for potential improvements in connection with customer offer and costs. One solution is to integrate inventories and offer improved order fulfilment by using both warehouse and
Purpose: To increase the understanding of storytelling in the realm of social entrepreneurship, and to highlight how storytelling is used in social entrepreneurial resource acquisition. Methodology: With an interpretivist and objectivist stance qualitative interview material has been collected from 9 respondents. Analysis and conclusions are based on an iterative interpretation of primary intervie
Purpose: This paper aims to uncover the associations and expectations consumers develop from a brand taking a political or social stance. We build upon existing literature to offer managers, and the research field, valuable insights to bridge the knowledge gap on what to consider before taking a stance. This paper guides the reader through a set of key considerations to evaluate before taking acti
Purpose: To investigate how the nation brand and country-of-origin of China jointly influence the European consumers’ perceptions towards Chinese smartphone brands. The reputation of Chinese smartphone brands in Europe is shaped by European consumers' concerns about China's national image over their global success and technological advancements. Hence, this study focuses on how these perce
