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Patients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno-arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre-planned prospective observational sub-study
The device or the formulation? Which one governs drug dispersibility from the inhaler? To address this question, three budesonide-containing reservoir DPIs: Novopulmon Novolizer®, Giona Easyhaler® and DuoResp Spiromax®, were analyzed using the Next Generation Impactor, NGI. Thereafter, the devices were carefully opened, emptied, and formulations were switched between devices. Finally, three ‘proto
In recruitment, promotion, admission, and other forms of wealth and power apportion, an evaluator typically ranks a set of candidates in terms of their perceived competence. If the evaluator is prejudiced, the resulting ranking will misrepresent the candidates’ actual ranking. This constitutes not only a moral and a practical problem, but also an epistemological one, which begs the question of wha
Students' understanding of forces in circular motion is often incomplete. The problems are not limited to confusions about centripetal acceleration and centrifugal forces. This paper considers possible effects of different interventions by a teacher who has discovered the many types of free-body diagrams drawn by students for circular motion in a vertical plane. Students' free-body diagrams often
Background: Antibiotics are commonly prescribed for outpatient management of cystitis. Previous evidence suggests that certain factors likely beyond the infection seem to influence the choice of antimicrobial treatment. However, studies on the specific antibiotic treatments for cystitis are lacking. This study aimed to explore the antibiotic treatments for cystitis using nationwide primary healthc
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive bronchoscopic procedure, well established as a diagnostic modality of first choice for diagnosis and staging of non-small cell lung cancer (NSCLC). The therapeutic decisions for advanced NSCLC require comprehensive profiling of actionable mutations, which is currently considered to be an essential
Background: GCA is a systemic vasculitis of the elderly, viewed by many as a disease with multiple and overlapping clinical phenotypes. Retrospective studies have shown differences in clinical presentation between these phenotypes. To reflect the heterogeneity of GCA and novel diagnostic methods, new classification criteria have been proposed. Methods: This is a retrospective study of newly diagno
The molecular sensitivity provided by optical photons has potential advantages in medical diagnostics, for example, in distinguishing healthy from cancerous tissue. However, scattering resulting from inhomogeneities in the refractive index of tissues prevents spatially resolved optical measurements in biological material, except at very shallow depths. This thesis presents research on a medical im
Private insurance is an important governance mechanism to prepare for environmental disasters triggered by floods. It forms part of risk management and climate adaptation approaches aimed at the reduction of vulnerability and the rebuilding of damaged structures. However, flood coverage is often low. Germany is no exception to this, although it is a member state of the EU and involved in implement
Background: Internet gaming disorder (IGD) was recently added in the Diagnostic and Statistical Manual of Mental Disorder as a “condition for further studies.” There is no consensus regarding which rating scales should be used but many scholars suggest the GASA (Game Addiction Scale for Adolescents) and a ranking of the criteria, “the core approach” to avoid over-diagnosing of disordered gaming. M
We use a case of intact cord resuscitation to argue for the beneficial effects of an enhanced blood volume from placental transfusion for newborns needing resuscitation. We propose that intact cord resuscitation supports the process of physiologic neonatal transition, especially for many of those newborns appearing moribund. Transfer of the residual blood in the placenta provides the neonate with
Det här dokumentet ger lokala politiker och tjänstemän ett processorienterat verktyg för att stärka förankringen (integreringen) av ekosystembaserad klimatanpassning i relevanta sektorer av kommunal verksamhet. Guiden presenterar systematiskt de nivåer och områden där förankring av ekosystembaserad klimatanpassning är viktigt, och möjliggör på så sätt planering och bedömning av åtgärder. Det övergThis guideline offers local government officers and local politicians process‐oriented assistance for integrating ecosystem‐based adaptation within relevant sectors of municipal administration with the aim of fostering sustainable urban development. It is thus an instrument to support leadership of this integration process. The levels and areas where integration of ecosystem‐based adaptation isrel
BACKGROUND: Resection is the cornerstone of curative treatment for many nonmetastatic gastric cancers (GCs), but the population treatment patterns remains largely unknown. This large international population-based study aimed at investigating the treatment patterns and trends for nonmetastatic GC in Europe and the United States and at exploring factors associated with resection.METHODS: Data of pa
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: Tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to result in loss of cartilage proteoglycans, the source of tissue fixed charge density (FCD). In order to
Aim: Understanding the spatial ecology of animal movements is a critical element in conserving long-lived, highly mobile marine species. Analyzing networks developed from movements of six sea turtle species reveals marine connectivity and can help prioritize conservation efforts. Location: Global. Methods: We collated telemetry data from 1235 individuals and reviewed the literature to determine ou
The energy sector is in urgent need for carbon-free strategies considering environmental pollutions and climate change impact. Two kinds of solid fuels, biomass and metal particles have been studied in this thesis aiming at CO2 emission reduction or zero carbon emission. Biomass is a renewable and carbon-neutral energy source that provides heat and power through gasification and combustion. Biomas
Biomaterials represent a potential means for the construction industry to reduce its negative ecological impact. These materials require substantially different approaches from conventional construction materials to maximise their potential. In this paper we have outlined four principles of biological design that we argue are central for the successful implementation of a new construction paradigm
