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Höje å har de senaste 200 åren blivit 50 procent kortare och förlorat 90 procent av avrinningsområdets våtmarker. För att kunna klara av framtida behov gällande matproduktion och utbyggnad av städer krävs effektiv avvattning av landskapet. Traditionella diken är bra på att avvattna mark, men medför många nackdelar för biologisk mångfald och näringstransport från jordbruksmark till havet. Tvåstegsd
Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr
Introduction: Discordant results between cystatin C and creatinine in estimating glomerular filtration rate (GFR) are an important medical issue. However, the equation that should be used when GFR estimates are discordant remains unclear. Methods: This cross-sectional analysis included 15,485 participants with GFR measured by the clearance of an exogenous marker, serum creatinine, and cystatin C.
The human influence on Earth's ecosystems is omnipresent. Artificial light at night (ALAN), anthropogenic noise, and air pollution are inherent features of human activities and infrastructure and pose novel environmental challenges to urban-dwelling wildlife. So far, most of the studies investigating the impacts of exposure to urban pollutants on animals have either investigated the effects of urb
Antalet personer som är 65 år eller äldre har fördubblats under de senaste 50 åren. Eftersom den äldre befolkningen ökar och vårdplatserna på sjukhus och boende minskar är hemrehabilitering en rehabiliteringsform som är mycket aktuell. Hemrehabilitering riktar sig till alla åldersgrupper, men majoriteten som får rehabilitering i hemmet är dock äldre. Syftet med vår studie var att studera arbetster
Våld mot kvinnor i nära relationer är ett socialt problem som blivit mer uppmärksammat de sista åren. Dock är mycket av våldet fortfarande dolt och sker inom hemmets fyra väggar. Vi har intervjuat tre kvinnor som blivit utsatta för denna typ av våld och även professionella som hjälper dessa kvinnor, för att undersöka varför kvinnor stannar kvar hos sina män som slår dem, hur de får styrkan att läm
För att se om brand regimerna i Sverige före större antropogena påverkningar skett år jämförbara med nutida Kanadensiska brand regimer jämförde jag två datasets av brand storlek och antal bränder. Man kan se likheter när Kanada och Sveriges brand regimer jämfördes, men eftersom sökarean varierade mycket (Kanada: hela landet, Sverige: 608km2) och den temporala upplösningen (Kanada: 41 år, Sverige: To assess if the fire regimes in Sweden before the strong human intervention are comparable to the recent Canadian fire regime I compared two datasets of fire numbers. A likeness could be found when comparing the Swedish and Canadian fire regimes, but due to the differences in study area (Canada: the whole state; Sweden 608km2) and time span (Canada: 41 years, Sweden: 800 years), no significant re
OBJECTIVE: To examine the effect of using a mitt during shortened constraint-induced movement therapy for patients in the subacute phase after stroke. SUBJECTS: Twenty-four patients with stroke (mean age 57.6 (standard deviation (SD) 8.5) years; average 7 weeks post-stroke) with mild to moderate impaired hand function. METHODS: The patients were randomized to mitt use or no mitt use on the less af
To determine intra- and interobserver reliability of the appearance and measurements of Cesarean hysterotomy scars using transvaginal ultrasound with and without saline contrast sonohysterography (SCSH) in non-pregnant women.
The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study"
Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e., metastatic melanoma (MM), the usual outcome is decreased survival. To improve survival rates and life span, advanced treatme
INTRODUCTION:Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis.METHODS:From a prospective population-based coh
Ectopic expression of transcription factors has been used to reprogram differentiated somatic cells toward pluripotency or to directly reprogram them to other somatic cell lineages. This concept has been explored in the context of regenerative medicine. Here, we set out to generate dendritic cells (DCs) capable of presenting antigens from mouse and human fibroblasts. By screening combinations of 1
Background: Residual tumor volume (RTV) and extent of resection (EOR) have previously been shown to affect survival in glioblastoma (GB) patients. Quantitative radiological assessment (QRA) of these factors could potentially affect clinical decision-making in the postoperative period. Purpose: The first aim was to evaluate the reproducibility of different volume estimation methods of RTV and EOR b
The study of biological mechanisms involved in human fetal brain development requires suitable models. To date, most findings have been acquired from animal models that fail to account for human-specific developmental traits. To counteract this limitation, a novel in vitro model is proposed where human pluripotent stem cells are differentiated into a coherent fetal brain tissue in a gradient formi
Noroviruses are the major cause for viral acute gastroenteritis in the world. Despite the existing infection prevention strategies in hospitals, the disease continues to spread and causes extensive and numerous outbreaks. Hence, there is a need to investigate the possibility of airborne transmission of norovirus. In this study, we developed an experimental setup for studies on the infectivity of a
Neurogenesis, the production of new neurons from neural stem cells, dramatically decreases during aging concomitantly with increased inflammation both systemically and in the brain. However, the precise role of inflammation and whether local or systemic factors drive the neurogenic decline during aging is poorly understood. Here, we identify CXCR5/5/CXCL13 signaling as a novel regulator of neuroge
The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell
Transcription factor (TF)-based reprogramming of somatic tissues holds great promise for regenerative medicine. Previously, we demonstrated that the TFs GATA2, GFI1B, and FOS convert mouse and human fibroblasts to hemogenic endothelial-like precursors that generate hematopoietic stem progenitor (HSPC)-like cells over time. This conversion is lacking in robustness both in yield and biological funct
