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The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on synd
The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry point for the prevention of PD. The World Health Organization (WHO) has recommended reducing exposure to specific environmental factors that have been reported
Navigation performance in urban and large-scale built-up spaces (e.g. airports, train-stations, hospitals) depends on gradual environmental perception during locomotion, and spatial knowledge acquisition, update/integration at different times along a path. Rotational locomotion is regularly involved in everyday navigation; this, combined with the fact that people cannot perceive the whole of a lar
BACKGROUND AND OBJECTIVES: To investigate the probable timing of events leading to cerebral palsy (CP) in singletons born small for gestational age (SGA) at term, taking neonatal death into consideration. METHODS: In this registry-based cohort study, data on 400 488 singletons born during 1996-2003 were abstracted from the Medical Birth and the CP registries of Norway. Among 36 604 SGA children (b
Purpose: To assess limits for significant improvement or deterioration of visual fields in diabetic patients based on short-term test–retest variability in subjects with different degrees of retinopathy. Methods: Fifty patients with diabetic retinopathy ranging from level 10 to 75 [according to the Early Treatment Diabetic Retinopathy Study (ETDRS) severity scale] were tested repeatedly with both
OBJECTIVE - To compare the sensitivity and specificity of luciferase immunoprecipitation (LIPS) with radioimmunoprecipitation (RIP) for the measurement of autoantibodies to the type 1 diabetes autoantigens glutamic acid decarboxylase 65 (GAD65) and insulinoma-associated protein (IA)-2 beta. RESEARCH DESIGN AND METHODS - Sera from 49 type 1 diabetic patients and 100 nondiabetic control subjects fro
The aim of this study is to provide a survey of systematic reviews that have evaluated the effects of psychosocial interventions for adult people with intellectual disabilities and/or an autistic syndrome with concurrent mental health problems. Reviews for inclusion were identified through searches of 10 electronic databases. The authors found that 3 out of 126 published reviews met the inclusion
Cationic polymers are used in anionic surfactant formulations to deposit and co-deposit actives on hair or skin surfaces. A series of cationic polymers, natural and synthetic, were investigated with surface and bulk techniques, turbidity measurements and in situ null-ellipsometry on silica surfaces in order to understand three key areas: the relation between the complex that is formed at a surface
Objective. Primary aldosteronism (PA) is the most common form of secondary hypertension. Thus, the aims of this study were: (1) to clarify whether the fludrocortisone suppression test (FST), which confirms autonomous aldosterone secretion, is reliable when carried out during a shorter period of time and (2) to confirm the importance of NaCl supplementation. The cut-off limits already obtained for
C3 nephritic factors are autoantibodies that prolong the half-life or prevent regulation of the alternative pathway C3 convertase, resulting in uncontrolled complement activation. They are strongly associated with renal disease but their role in pathogenesis remains controversial. Here we optimized and compared a panel of assays to identify and interrogate nephritic factor activities. Of 101 patie
Background: Rehabilitation is effective and beneficial for patients with arthritis. The lack of a common structure for describing the content of rehabilitation makes it difficult to compare, transfer and implement research evidence into clinical practice. Objective: To develop a framework comprising domains and elements of importance when describing arthritis rehabilitation. Methods: On the basis
Weak separability is an important concept in many fields of economic theory. This chapter uses Monte Carlo experiments to investigate the performance of newly developed nonparametric revealed preference tests for weak separability. A main finding is that the bias of the sequentially implemented test for weak separability proposed by Fleissig and Whitney (2003) is low. The theoretically unbiased Sw
Here, we present the activities within our research group over the last five yearswith cantilevers fabricated in the polymer SU-8. We believe that SU-8 is an interestingpolymer for fabrication of cantilevers for bio/chemical sensing due to its simple processingand low Young’s modulus. We show examples of different integrated read-out methodsand their characterisation. We also show that SU-8 cantil
Popular Abstract in Swedish Fibromodulin och dystrofin i ateroskleros; en populärvetenskaplig sammanfattning VAD ÄR ATEROSKLEROS? Ateroskleros – det man tidigare kallade för åderförkalkning – är grundorsaken till hjärtinfarkt, stroke och kärlkramp. Ett aterosklerosplack är en förträngning i ett blodkärl, ofta vid en förgrening där blodflödet är turbulent. Placket börjar ofta växa redan i unga år Cardiovascular disease represents nearly half the cases of noncommunicable diseases worldwide and is the leading global cause of death. The main underlying cause is atherosclerosis, and in atherosclerotic plaque progression the structure, composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between th
Realistic radio channel models are crucial for the success of vehicle-to-vehicle (V2V) system investigations. In this paper, we summarize the important parameters for V2V channel models and describe relevant measurement campaigns. Also, we develop and evaluate an ns-3 simulation model of a realistic V2V channel model that is based on measurements in Sweden. The channel model incorporates the effec
The use of duty-cycled ultralow-power wake-up receivers (WRxs) can significantly extend a node lifetime in low-power sensor network applications. In the WRx design, both the low-power operation of the WRx and the wake-up beacon (WB) detection performance are of importance. We present a system-level analysis of a duty-cycled WRx design, including an analog front end, a digital baseband, the WB stru
With the evolving technology of mobile electronics and other forms of communication methods, an increasing demand of speech intelligibility is introduced. In a conference room for example, multiple microphones are placed directly in front of the speaker in order to pick up clean speech. However, several challenges still exist. For instance the distance between speaker and microphone will not be fi
The purpose of this thesis is to investigate the impact of exchange rate volatility on aggregate foreign trade. We use annual data from 15 Asian countries over 30 years. The exchange rate volatility is derived primarily based on GARCH models and MASD. This thesis applies both the static fixed-effect panel data model and dynamic GMM model, then compares the obtained results and uses the OLS method
The food system accounts for a significant portion of environmental degradation, while it is at the same time to a large extent producing food that is deteriorating to human health. The private sector plays an essential role in contributing to the sustainability of the system. Based on a systematic literature review, we conceptualise the notion of sustainable nutrition (SN), which highlights the i
