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Critical scholarship on the intersection of development pathways and climate change responses highlights the roles of power, agency, social difference, intersecting inequalities, and social justice in shaping people's resilience in a rapidly transforming world. Yet, how to precisely increase the spaces in which people experiencing marginalisation can address power asymmetries and strengthen their
The polar region is experiencing one of the most rapid environmental changes driven by atmospheric warming, and feedbacks within the cryosphere. Under such a setting, it is crucial to understand the biogeochemical cycling of the nutrient silicon (Si) in the high latitudes, which is regulating the nutrient supply to polar ecosystems, and is linked to the global carbon cycle via diatom production. H
The Ambient-Pressure X-ray Photoelectron Spectroscopy (APXPS) endstation at the SPECIES beamline at MAX IV Laboratory has been improved. The latest upgrades help in performing photo-assisted experiments under operando conditions in the mbar pressure range using gas and vapour mixtures whilst also reducing beam damage to the sample caused by X-ray irradiation. This article reports on endstation upg
Host-pathogen protein-protein interactions are highly complex and dynamic and mediate key steps in pathogen adhesion to host, host invasion, and colonization as well as immune evasion. In bacteria, these interactions most often involve specialized virulence factors or effector proteins that specifically target central host proteins. Here, I present a mass spectrometry-based proteomics approach sta
BACKGROUND: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D).METHODS: We conducted a systematic review and meta-analysis of longitudinal studies to identify potentially novel prognostic factors that could improve CVD risk prediction in T2D. Out of 9380 studies identified, 416 studies met inclusion criteria. Outco
Modern microbial and ecosystem sciences require diverse interdisciplinary teams that are often challenged in “speaking” to one another due to different languages and data product types. Here we introduce the IsoGenie Database (IsoGenieDB; https://isogenie-db.asc.Ohio-state.edu/), a de novo developed data management and exploration platform, as a solution to this challenge of accurately representin
State-structured populations are ubiquitous in biology, from the age-structure of animal societies to the life cycles of parasitic species. Understanding how this structure contributes to eco-evolutionary dynamics is critical not only for fundamental understanding but also for conservation and treatment purposes. Although some methods have been developed in the literature for modelling eco-evoluti
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for C
High-throughput imaging allows in vitro assessment of neuron morphology for screening populations under developmental, homeostatic, and/or disease conditions. Here, we present a protocol to differentiate cryopreserved human cortical neuronal progenitors into mature cortical neurons for high-throughput imaging analysis. We describe the use of a notch signaling inhibitor to generate homogeneous neur
We present MultiPsi, an open-source MCSCF program for the calculation of ground and excited states properties of strongly correlated systems. The program currently implements a general MCSCF code with excited states available using either state-averaging or linear response. It is written in a highly modular fashion using Python/C++ which makes it well suited as a development platform, enabling eas
Ensuring functional safety is a critical challenge for autonomous robots, as they must operate reliably and predictably despite uncertainty. However, existing safety measures can over-constrain the system, limiting the robot’s availability to perform its assigned task. To address this problem, we propose a more flexible strategy that equips robots with theability to adapt to system failures and re
A novel dual-amplification system based on CRISPR-Cas12a and horseradish peroxidase (HRP) was developed for colorimetric determination of MC-LR. This dual-amplification was accomplished by combining the nuclease activity of CRISPR-Cas12a with the redox activity of HRP. HRP linked to magnetic beads through an ssDNA (MB-ssDNA-HRP) was used to induce a color change of the 3,3′,5,5′-tetramethylbenzidi
The food industry is actively adopting carbon neutral strategies aligned with the principles of Industry 4.0 to establish long-term goals for reducing carbon emissions and accelerating the transition to a low-carbon food production industry. Industry 4.0, often referred to as the fourth industrial revolution, emphasizes the integration of digital technologies, automation, and data exchange into ma
Seaweed is depicted as a future food in Western cultures, yet its introduction and expansion to new markets come with several challenges, including food neophobia and limited knowledge about its usability. To address these challenges, this study characterizes sensory perceptions, nutritional content, and physicochemical properties of four common northern European seaweed species, Saccharina latiss
Background: Eugenol is a known contact sensitiser included in fragrance mix I. Objective: To assess the allergic reactivity to eugenol in different concentrations using patch test as well as repeated open application test (ROAT). Methods: Overall 67 subjects from 6 European dermatology clinics participated in the study. The ROAT was performed for 21 days twice a day, applying 3 dilutions of eugeno
All patients with palliative and end of life care needs should be guaranteed equal and safe treatment and care, regardless of their disease or site of care. The inclusion of quality indicators in national guidelines and other guiding documents supports quality assurance and improvement in provision of care. The aim of this paper was to review existing quality indicators in national Swedish policy
Our aim was to identify the best diagnostic test sequence for predicting Alzheimer's disease (AD)-type dementia in subjects with mild cognitive impairment (MCI) using cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) biomarkers. We selected 153 subjects with mild cognitive impairment from a multicenter memory clinic-based cohort. We tested the CSF beta amyloid (A beta)1-42/tau ratio u
Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate-and Swedish high-dose prophylactic regimens for patients with severe hemophilia (factor VIII/IX < 1 IU/dL) b
Achieving QoS-based broadband wireless access means a lot for the people living in the information age. WiMAX has evolved now into a stage that we can say it can meet this demand. From among the various fields to study in this domain, call admission and scheduling are the strongest tools in our hand to ensure QoS. On the other side, exploiting mesh topology is a good technique to increase the netw
Biogenic silica (BSi) is used as a proxy by soil scientists to identify biological effects on the Si cycle and by palaeoecologists to study environmental changes. Alkaline extractions are typically used to measure BSi in both terrestrial and aquatic environments. The dissolution properties of volcanic glass in tephra deposits and their nanocrystalline weathering products are hypothesized to overla
