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BACKGROUND: Maternally derived duplications of the 15q11-q13 region are the most frequently reported chromosomal aberrations in autism spectrum disorders (ASD).Prader-Willi and Angelman syndromes, caused by 15q11-q13 deletions or abnormal methylation of imprinted genes, are also associated with ASD. However, the prevalence of these disorders in ASD is unknown. The aim of this study was to assess t
For years tools and techniques such as Brainstorming, Mind-Maps and Rich Pictures have been used in both academic and professional practices to assist people with making sense of complex problem spaces. These tools have their supporters and in many cases their uses can be argued to be interchangeable. Seldom however have they been systematically applied in combination in theory or practice. Even t
Popular Abstract in Swedish Människan har märkbart ändrat Jordens ekosystem och dess funktioner. Genom avskogning och konvertering av naturliga ekosystem till åkrar och betesmarker så har människor skapat helt nya typer av ekosystem. Cirka en tredjedel av den koldioxid (CO2) som människor har släppt ut i atmosfären, kommer från dessa aktiviteter, resten beror till största delen på utsläpp från förThrough deforestation and conversion of natural ecosystems to croplands and pastures, have humans released vast amounts of carbon (C) dioxide (CO2) into the atmosphere. Roughly one third of the cumulative anthropogenic emissions until today stem from these practices, the remainder being mostly due to fossil fuel combustion. The extra CO2 has caused an increase in global air temperature, and both t
Investigation of a novel condition monitoring approach, combining artificial neural network (ANN) with a sequential analysis technique, has been reported in this paper. For this purpose operational data from a Siemens SGT600 gas turbine has been employed for the training of an ANN model. This ANN model is subsequently used for the prediction of performance parameters of the gas turbine. Simulated
The present work is mainly focused on the development of enzyme-based bioanalytical devices, which can further be applied as analytical tools for industrial, medical and environmental applications. The first part of the work deals with the practical applications of thermometric biosensors for determination of various sugars (fructose and lactose) in a real samples. Thermometric biosensors possess
Water vapor condensation and two-phase flow appear in plate heat exchangers being used as condensers. Analysis of water phase change and flow dynamics is an important but complicated task due to large change in water physical/transport properties across the water liquid-vapor interface boundary. In particular, a singular-link behaviour in Navier-Stokes (N-S) equations is present due to the large s
Testing is used to ensure high quality chip production. High test quality implies the application of high quality test data; however, the technology development has lead to a need of an increasing test data volume to ensure high test quality. The problem is that the test data volume has to fit the limited memory of the ATE (Automatic Test Equipment). In this paper, we propose a test data truncatio
Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. Antiproliferative spermine-binding DS fragments (tetra- to decasaccharides), and aff
Combining the strengths of an advanced mathematical model of human physiology and a thermal manikin is a new paradigm for simulating thermal behaviour of humans. However, the forerunners of such adaptive manikins showed some substantial limitations. This project aimed to determine the opportunities and constraints of the existing thermal manikins when dynamically controlled by a mathematical model
Popular Abstract in Swedish Strålbehandling är en av de vanligaste behandlingarna mot cancer. Hälften av alla behandlingar syftar till att bota patienten från sjukdomen, men strålbehandling är även en mycket effektiv behandling för att lindra smärta och andra symptom för patienter med en obotlig cancer. Förberedelse inför strålbehandling är en komplicerad procedur, som innefattar många olika teknPreparation for radiotherapy is a complex procedure that involves many different technologies and groups of professionals. The rapid development and introduction of new technologies throughout the last decade have made it possible to deliver highly conformal, individually-shaped dose distributions with high accuracy. However, there is widespread concern that current quality assurance practices hav
What kind of indispensable cognitive ability is needed for intelligence, sociability, communication, and technology to emerge on a habitable planet? My answer is simple: intersubjectivity. I stress the significance of intersubjectivity, of shared cognition, for extraterrestrial intelligence and interstellar communication, and argue that it is in fact crucial and indispensable for any successful in
This thesis is divided into two parts in which two different aspects of the Large Hadron Collider (LHC) Project are discussed. The first part describes the design of a transition radiation tracker (TRT) for the inner detector in ATLAS. In particular, the barrel part was studied in detail. The barrel TRT consists of 52 544 1.5-m-long proportional tubes (straws), parallel to the beam axis and each
